Xenon Pharmaceuticals Inc.

Chief Marketing Officer

• Lead the design, optimization, and execution of the Commercial Review Committee (CRC/MLR) process, ensuring alignment with Marketing, Regulatory, Legal, Medical, and Compliance stakeholders
• Continuously assess and improve CRC workflows, identifying bottlenecks, redundancies, and cycle-time challenges; proactively propose and implement solutions to enhance efficiency and quality
• Serve as primary CRC operations lead, either directly coordinating reviews or managing an outsourced/vendor-supported model depending on capacity and business needs
• Establish and manage CRC governance forums, including coordinating CRC steering committees, setting agendas, and aligning stakeholders on process improvements and priorities
• Lead and coordinate the Executive Review Committee escalation governance committee
• Partner with IT and cross-functional teams to manage systems supporting CRC workflows (e.g., Veeva PromoMats or similar), including user access, license management, and system enhancements
• Lead the development and delivery of training programs for CRC processes, systems, and ways of working across Marketing and cross-functional partners
• Stay current on industry best practices, emerging technologies, and innovation (including AI-enabled content and review solutions); identify opportunities and drive adoption of new capabilities to improve efficiency and scalability
• Collaborate cross-functionally to evaluate and enhance the end-to-end content lifecycle, including:
• Content intake and planning
• Content creation and modular content strategy
• Digital asset management (DAM) and content libraries
• Content reuse and optimization
• Develop and align stakeholders to a forward-looking roadmap for content operations maturity and implement prioritized enhancements
• Lead the vendor selection, process development, and day to day coordination with marketing and other partners on materials printing and fulfillment management
• Partner closely with Marketing leadership to forecast review volume, assess capacity, and plan for fluctuations in workload and complexity
• Proactively identify risks related to throughput, timelines, or resource constraints and develop mitigation plans in alignment with cross-functional stakeholders
• Drive integrated planning and scheduling of marketing materials through the CRC process to ensure timely delivery of key campaigns, launches, and field materials
• Act as a central point of coordination across Marketing, Regulatory, Legal, Medical, and Compliance to ensure alignment on priorities and timelines
• Manage external vendors and agency partners supporting:
• CRC operations (if outsourced components are implemented)
• Print, fulfillment, and material distribution
• Define scope of work, performance expectations, and service-level agreements (SLAs) for vendors
• Monitor vendor performance against KPIs and drive continuous improvement
• Track budgets related to marketing operations and vendor services, ensuring efficient and compliant resource utilization
• Define, implement, and track KPIs for marketing operations and CRC performance, including cycle times, approval rates, rework levels, and throughput
• Develop and maintain operational dashboards and reporting to provide transparency into process performance and identify improvement opportunities
• Use data-driven insights to continuously refine processes and improve effectiveness
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any
• Some international travel may be required
• Other duties as assigned

Senior Manager – Marketing Operations, Commercial Review

Director

• Collaborate with internal and external partners on developing and operationalizing Xenon’s commercial data ecosystem across pre-launch, launch, and post-launch phases
• Manage and define how commercial data will be governed, documented, validated, accessed, escalated, and used across the organization
• Serve as the primary commercial business partner managing Xenon’s core data service partners (e.g. CDW, Data Aggregator, MDM, etc.) and data source partners, (e.g. Claims, Rx, SP, Payer, etc.) IT Partnership
• Partner closely with IT on commercial data platform implementation, platform enhancements, system dependencies, integration patterns, security, compliance, performance, lineage, and architecture alignment
• Translate cross-functional commercial priorities into clear data management requirements, data ownership models, business rules, decision rights, and operating processes
• Serve as a commercial business owner or key steward for commercial master data management across HCP, HCO, affiliations, addresses, hierarchy, payer, payer bridge, customer master, and related identity domains
• Establish and maintain data dictionaries, critical data elements, metadata, lineage, and business definitions for priority commercial master data domains
• Design and manage a data stewardship process to ensure data quality issues are identified, communicated, prioritized, and resolved through consistent business-facing processes
• Define, monitor, and evolve data quality rules, validation checks, reconciliation processes, completeness expectations, timeliness standards, accuracy thresholds, and issue escalation pathways
• Support development of a governed KPI/metrics catalog into report-ready data assets with accompanying data dictionaries
• Translate KPI and dashboard requirements into upstream data definitions, business rules, transformation logic, and validation expectations, for reporting and dashboard use
• Partner with internal and vendor teams on go-live readiness (e.g. platform implementation, UAT, analytics/dashboards, etc.) and lifecycle management of data assets (e.g. Rx, Claims, CRM, payer, omnichannel engagement data, etc.)
• Define commercial requirements for ingestion, data mapping, transformation, quality control, data dissemination, archival, lineage, and reporting readiness
• Coordinate cross-vendor dependencies to ensure commercial data flows are complete, accurate, timely, and aligned to launch and steady state needs
• Manage or support vendor deliverables including file layouts, data dictionaries, data transfer schedules, issue logs, quality checks, test files, SLA performance, and launch-readiness milestones
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies
• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any
• Some international travel may be required
• Other duties as assigned

Associate Director/Director, Commercial Data Management

Financial Planning and Analysis

• Serve as the primary finance partner to the Commercial organization, providing financial leadership, guidance, and insight across pricing, payer mix, pipeline conversion, top line performance, and operating expenses
• Design, implement, and maintain GTN reserve methodologies, including documentation of reasonable assumptions: commercial and government rebates, chargebacks, copay and patient assistance programs, distribution service fees, returns and other variable consideration
• Responsible for monthly close processes for revenue, GTN, and operating expenses including journal entries, account reconciliations, true ups, and variance analysis
• Lead all financial reporting initiatives for the Commercial function, including accruals and monthly and quarterly reporting of financial results for management and department heads
• Manage the quarterly forecasting process by partnering with department managers to align the forecast with the most current business assumptions; ensure alignment between Commercial revenue forecast and guidance and report against such guidance, including analysis of pricing actions, margin dynamics, and market trends
• Manage government pricing reporting and ensure appropriate compliance with regulatory requirements
• Work within finance systems to implement or enhance systems to address planning and reporting needs of commercial accounting and GTN processes
• Establish and maintain scalable data flows with 3PLs and other parties; review data provided by external parties for completeness, accuracy, and reasonable
• Build SOX compliant internal controls, policies, and SOPs in preparation for commercial launch and first audit cycles
• Serve as the primary commercial accounting contact for external auditors
• Prepare analysis, commentary, and presentation materials for monthly and quarterly financial reviews, including executive leadership and Board of Directors meetings
• Partner with Commercial team on long range planning, pricing strategy, and strategic investment analysis related to commercial growth opportunities
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports
• Other duties as assigned

Director, Commercial Accounting – FP&A

• Ensure Xenon’s products are quickly reviewed post approval to ensure rapid formulary adoption enabling patient access that is equal to branded products in relative categories Xenon competes in:
• Establish and maintain multiple touch points at strategic payer accounts, including senior executives, to communicate the Xenon payer value story
• Navigate payer organizations to build long-term relationships with key decision makers and potential influencers paving the way for the pipeline of innovative products from Xenon
• Have complete understanding of the complex payer organizations and different wholly owned subsidiaries who may have services and programs that impact the Epilepsy class. Monitor to assess opportunities for partnerships long term
• Prioritize top accounts using data and personal intelligence
• Secure access and coverage rapidly for all Xenon products that is at parity with key competitors in respective classes
• Develop strategic business plans by account
• Secure appropriate coverage and formulary positioning in alignment with Commercial goals working collaboratively with Medical Affairs and Value and Access to ensure the value proposition and HEOR data is appropriately communicated to target audiences
• Evaluate contracting opportunities that are consistent with Xenon’s goals. Lead the contract process from initiation to negotiation/completion. Manage ongoing contracts with quarterly business reviews and evaluate ROI
• Review data (sales trends, competitive landscape by local market) to identify pull-through opportunities. Work with regional sales directors and sales representatives to address access challenges and maximize success by executing aligned pull-through plans.
• Assist in field training on access and reimbursement
• Deliver payer insights back to market access, medical affairs, and patient services as appropriate.
• Represent Xenon at Key Industry Conferences (e.g., AMCP, Asembia, PCMA)
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies
• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any
• Some international travel may be required
• Other duties as assigned

Director, Payer Accounts – West Region

• Lead the development of the US HCP education strategy aligned to brand goals, lifecycle stage (including launch-readiness), and key customer segments.
• Translate brand strategy, positioning, and customer insights into actionable, differentiated education plans.
• Identify priority HCP segments (specialists, community providers, advanced practice providers, etc.) and tailor education approaches accordingly.
• Serve as the education lead in brand planning, ensuring strong integration across omnichannel touchpoints.
• Oversee the design and execution of HCP education programs, including:
• Peer-to-peer programs and speaker bureaus
• Congress strategy and educational presence
• Workshops, advisory boards, and training events
• Digital and on-demand learning platforms
• Develop compelling, insight-driven educational content aligned to clinical data and brand narrative.
• Ensure consistent and differentiated HCP experience across channels and programs.
• Act as a central integrator across Marketing, Customer Engagement, Medical Affairs, Field Sales, Market Access, and Customer Experience teams.
• Partner closely with:
• Brand leads on strategy and messaging
• Medical Affairs on scientific accuracy and non-promotional education
• Field teams to enable execution and feedback loops
• Align with regulatory, legal, and compliance partners to ensure all programming meets internal and external standards.
• Build and manage relationships with key opinion leaders (KOLs), faculty, and professional societies.
• Support pre-launch readiness by:
• Mapping educational gaps and opportunities
• Building foundational disease-state education
• Developing launch-phase HCP onboarding and training strategies
• Manage and lead external agency partners and vendors
• Own professional education marketing budget, ensuring effective resource allocation
• Define KPIs and success metrics (engagement, reach, behavior change, impact on brand performance).

Director, HCP Marketing

Account Executive

• Ensure Xenon’s products are quickly reviewed post approval to ensure rapid formulary adoption enabling patient access that is equal to branded products in relative categories Xenon competes in
• Establish and maintain multiple touch points at strategic payer accounts, including senior executives, to communicate the Xenon payer value story
• Navigate payer organizations to build long-term relationships with key decision makers and potential influencers paving the way for the pipeline of innovative products from Xenon
• Have complete understanding of the complex payer organizations and different wholly owned subsidiaries who may have services and programs that impact the Epilepsy class. Monitor to assess opportunities for partnerships long term
• Prioritize top accounts using data and personal intelligence
• Secure access and coverage rapidly for all Xenon products that is at parity with key competitors in respective classes
• Develop strategic business plans by account
• Secure appropriate coverage and formulary positioning in alignment with Commercial goals working collaboratively with Medical Affairs and Value and Access to ensure the value proposition and HEOR data is appropriately communicated to target audiences
• Evaluate contracting opportunities that are consistent with Xenon’s goals. Lead the contract process from initiation to negotiation/completion. Manage ongoing contracts with quarterly business reviews and evaluate ROI
• Review data (sales trends, competitive landscape by local market) to identify pull-through opportunities. Work with regional sales directors and sales representatives to address access challenges and maximize success by executing aligned pull-through plans.
• Assist in field training on access and reimbursement
• Deliver payer insights back to market access, medical affairs, and patient services as appropriate.
• Represent Xenon at Key Industry Conferences (e.g., AMCP, Asembia, PCMA)
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies
• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any
• Some international travel may be required
• Other duties as assigned

National Account Director, Payer Accounts

Operations

• Build and operationalize Xenon’s field effectiveness infrastructure to support launch readiness and execution
• Partner with departments to translate launch strategy into field-ready processes, tools, and operating rhythms
• Serve as a primary Commercial Operations partner to field strategy and leadership
• Develop and produce field execution analytics and identify gaps in execution quality
• Collaborate on territory alignment, targeting refinement, and related vendor workstreams
• Own targeting operations and refinement processes
• Serve as the business owner for field-facing systems and tools, including CRM and field reporting
• Lead incentive compensation operations and support decision-making with operational insights
• Identify and implement AI-enabled solutions to improve field productivity

Director, Field Effectiveness – Operations

Communications

• Develop and execute communications strategies to promote and protect the Company's reputation.
• Focus on Corporate, Investor, Executive and R&D communications.
• Provide strategic execution of tactical implementation associated with corporate newsflow, including business updates, clinical trial milestones, data readouts and future product launches.
• Coordinate across internal stakeholders to deliver corporate messaging and programming.
• Ensure external and internal communications are closely aligned.
• Work with the CEO, CFO, CMO, CCO and other senior leaders to execute the Corporate and Investor Relations strategy, manage relationships with investors and analysts, and effectively develop messaging and communications for our scientific, clinical, and financial progress.

Director, Corporate Communications

• Contribute to development of annual and long-term internal communications strategies, objectives and initiatives
• Manage internal communications and corporate engagement initiatives
• Collaborate with key stakeholders to develop internal content for the corporate intranet, companywide emails, town halls and department leader meetings
• Act as a Vancouver-based event lead by executing large- and small-scale corporate events
• Manage logistics and execution of executive and senior leadership team offsites
• Contribute to forward-looking communications plans and systems for remote employees
• Source and manage branded items, oversee vendor relationships and project logistics
• Manage contract and invoice tracking and submissions for the Corporate Affairs department
• Proactively identify and propose solutions for challenges and/or process improvements
• Support initiatives driven by external communications, patient advocacy, and other corporate affairs functions

Manager, Internal Communications

• Define and execute a holistic commercial learning strategy aligned to business priorities and go-to-market objectives
• Design and implement comprehensive training programs across: Product, disease state, and market access education; Selling skills and account-based engagement models; Systems and tools training
• Build structured learning journeys spanning onboarding, advanced development, and ongoing capability enhancement
• Translate strategic priorities into role-specific, applied learning experiences
• Own training readiness for launch, including curriculum design, certification, and delivery
• Partner with Sales and Marketing to align training to brand strategy, messaging, and milestones
• Ensure field teams are fully prepared with the knowledge and skills required to execute from day one
• Design and implement leadership development programs for Regional Sales Managers and emerging leaders
• Equip front-line leaders with frameworks, tools, and approaches to effectively coach and develop their teams
• Develop high-quality, engaging learning experiences including workshops, virtual sessions, simulations, and e-learning
• Assess field capability using structured assessments, training metrics, and input from field leadership and execution teams
• Measure training effectiveness through knowledge outcomes, skill development, and readiness indicators
• Lead the learning strategy and training components of national and regional meetings
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

Director, Commercial Learning – Field Enablement

• Lead the proactive signal detection activities, support the ongoing benefit-risk analyses, and safety monitoring/reporting activities for Xenon products across all stages of development.
• Lead and manage Aggregate Safety Reports (e.g., IND/NDA Annual Reports, PADER, DSUR, PSUR, PBRER, ad-hoc regulatory responses, etc.) for Xenon products throughout product lifecycle from FIH to post-marketing in compliance with global safety regulations and guidelines and provide training within DSPV and cross-functionally.
• Author Aggregate Safety Reports while working in collaboration with the cross functional teams (i.e. Non-clinical, Clinical Development, Trial Operations, Regulatory, Biostatistics, and Clinical Data Management) to compile safety information.
• Support and review safety-related documents for Xenon products throughout product lifecycle from FIH to post-marketing such as Safety Assessment Reports, product labeling, risk management/risk mitigation-related documents, and responses to ad-hoc information requests by Health Authorities and internal stakeholders.
• Review safety concerns escalated from internal and external stakeholders, including competent regulatory authorities, and support safety team to develop safety related responses.
• Maintain continuous monitoring/updating of safety profiles for assigned investigational and marketed products. Collaborates with physicians and risk management team in ongoing risk/benefit assessment.
• Performs careful review of all serious events of interests and expedited individual case safety reports ensuring that the knowledge gained from these individual reports contribute to a higher degree of interpretation, consistency, and quality of the analysis at the aggregate level. Reviews and provides input to Analysis of Similar Events (AoSE), as needed.
• Review and communicate trending, signaling, and other safety-related issues originating from any source for the purposes of detecting and reviewing safety signals (e.g., change in frequency, nature, or severity of a safety-related issue) in a timely manner.
• Participates and contributes to cross-functional SRMT meetings for signal management, risk management detection, and benefit-risk assessment for Xenon products.
• Review potential issues and safety signals and contribute to the SRMT and Safety Governance process through the preparation and presentation of safety data; prepare and assess safety data for ongoing periodic / aggregate safety data review.
• Author the safety signal assessment reports in collaboration with Safety Physicians.
• Support the risk management team in the development of risk management strategies and activities.
• Review SMP and provide input to safety related sections of clinical study documents including Study Protocols, Informed Consent Forms (ICF), Clinical Study Reports (CSR), SAPs, DSMB charters, and other relevant documents.
• Write and maintain relevant SOPs and procedures in compliance with global regulations and guidelines.
• Support inspections by participating in audit preparedness activities and providing requested information.
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
• Other duties as assigned.

Director/Senior Director, Pharmacovigilance and Drug Safety

Clinical Research

• Provide scientific leadership and independent contribution to study design, protocol development, endpoint strategy, and clinical development planning for assigned programs.
• Support the development, implementation, conduct, oversight, and reporting of clinical trials, ensuring scientific quality and alignment with program objectives.
• Perform comprehensive literature reviews and maintain current knowledge of disease areas, competitive landscape, emerging science, and regulatory developments relevant to assigned products and indications.
• Participate in the review, monitoring, summarization, and interpretation of safety, efficacy, pharmacokinetic, patient-reported outcome, and other clinical data to support development decisions and recommendations.
• Collaborate cross-functionally with Clinical Operations, Biometrics/Biostatistics, Data Management, Pharmacovigilance, Medical Writing, Regulatory, Translational Development, Medical Affairs, and other partners to support high-quality study execution and documentation.
• Draft, review, and contribute to clinical and regulatory documents, including study protocols, synopses, investigator brochures, clinical study reports, health authority submission content, briefing materials, abstracts, posters, and manuscripts.
• Support or lead scientific interactions with CROs, investigators, site personnel, and external collaborators to ensure consistency, scientific integrity, and effective study execution.
• Contribute to advisory boards, expert meetings, and other scientific interactions that support program development and evidence generation.
• Support the development of departmental processes, templates, standard operating procedures, and best practices as needed.

Clinical Scientist 3, Clinical Development

• Provide scientific leadership and independent contribution to study design, protocol development, and clinical development planning
• Support the development, implementation, conduct, oversight, and reporting of clinical trials
• Perform comprehensive literature reviews and maintain current knowledge of relevant disease areas
• Participate in the review and interpretation of clinical data
• Collaborate cross-functionally with Clinical Operations, Data Management, etc.
• Draft and contribute to clinical and regulatory documents
• Support or lead scientific interactions with CROs, investigators, and external collaborators
• Develop and maintain productive relationships with external scientific experts

Clinical Scientist 2, Clinical Development

Manager

• Lead and manage data management activities for assigned products, initiatives and/or clinical trials
• Design clinical trial databases, including CRF Development, Database Validation, and Data Review tools
• Oversee external data management vendors
• Optimize data management and collection activities
• Maintain current knowledge of relevant issues related to data management
• Propose, draft, and maintain relevant Standard Operating Procedures
• Act in accordance with Company policies

Senior Manager, Data Management

• Provide clinical trial management leadership for multiple Phase 3 studies, across therapeutic areas.
• Collaborate with cross-functional team members to ensure highly integrated plans and documents for clinical trials.
• Develop, propose, and manage plans for assigned studies and activities.
• Lead the preparation of Requests for Proposals (RFPs) in collaboration with other internal team members.
• Manage contracted service providers to deliver against the contracts.
• Lead the selection of qualified investigators and study sites in collaboration with the Clinical Development team.
• Review and oversee study budgets and invoices to ensure vendors are invoicing in accordance with their contracts.
• Develop and manage study timeline and study metrics cross-functionally.
• Conduct risk assessments, mitigation strategies and contingency planning.
• Communicate with internal/external teams to proactively recognize challenges and work cross-functionally on strategies to mitigate/resolve.
• Actively participate in all aspects of clinical trial operations, including the coordination, writing, review and/or finalization of clinical trial protocols, consent forms, case report forms, study plans, safety reviews and other essential regulatory documents.
• Train and mentor new staff or peer mentorship of new hires.
• Oversee adherence to applicable regulations, recognized guidelines, clinical trial protocol, and standards of clinical practice.
• Participate in the development and updating of standard operating procedures as required.