Definium Therapeutics

Medical Director

• Act as the primary IT point of contact for Commercial and Medical Affairs leadership, developing strong, trust-based partnerships
• Understand the Commercial and Medical Affairs strategy, business goals, and operational challenges, aligning business objectives to clear, prioritized IT initiatives and requirements
• Support systems and new product introduction by providing technical expertise, system administration, problem solving, and strategies for risk mitigation
• Support the overall governance and lifecycle management of commercial and Medical Affairs systems and platforms. (e.g., Veeva Vault CRM, Open Data, Link, Approved Email)
• Lead requirements gathering, documentation, and testing for commercial and Medical Affairs platforms. Ensure configuration, enhancement, and expansion of the systems aligns with broader organizational data standards, information security practices, and regulatory needs
• Work closely with IT and Legal to ensure data protection controls such as segmentation and access boundaries are designed, implemented, and consistently enforced in alignment with regulatory requirements
• Ensure alignment between business demand and IT capacity and prioritization
• Provide oversight and system administration across SaaS platforms supporting Commercial operations and Medical Affairs. (e.g., CRM, field enablement, analytics, content management)
• Ensure solutions are scalable, user-centric, and aligned with enterprise architecture standards
• Monitor delivery risks, dependencies, and change impacts; escalate as appropriate
• Serve as a clear communicator between technical and non-technical stakeholders
• Drive change management, user adoption, and ongoing optimization of deployed solutions.
• Note that this is a hands-on role. A successful candidate will be expected to execute all above requirements with minimal assistance from staff.

Director, IT System Business Partner – Commercial and Medical

QA Engineer

• Partner cross-functionally with IT and the business to implement and maintain compliant computerized systems
• Provide quality oversight for the lifecycle of computerized systems, ensuring compliance with GAMP 5, 21 CFR Part 11, and Data Integrity standards
• Serve as the QA CSV SME during vendor evaluations, software implementation and qualification and requalification of GxP systems
• Support continuous improvement of GxP Systems through SOP development, training, and change control management
• Partner with IT and Business teams to ensure SDLC and validation requirements are clearly defined and met
• Lead investigations for CSV-related deviations, system failures, and data integrity issues, including root cause analysis
• Review and approve Computer System Validation (CSV) documentation including Validation Plans, IQ/OQ/PQ protocols, and summary reports
• Advise on data integrity best practices and approaches
• Partner with IT to ensure inspection readiness is maintained for CSV
• Serve as QA reviewer for all new system releases and change controls
• Perform internal audits to ensure systems are maintained in a steady state and user management is under control
• Ensure adherence to regulatory and quality standards throughout the software development lifecycle
• Support systems and new product introduction by providing QA expertise, problem solving, and strategies for risk mitigation
• Support validation and QA oversight of AI/ML-enabled GxP systems, including risk assessment for model changes and ongoing performance monitoring

Senior Specialist, Quality Assurance, CSV

Financial Planning and Analysis

• Process purchase requisitions and convert them into purchase orders in Coupa
• Review requisitions for completeness, accuracy, and policy compliance
• Partner with internal stakeholders to resolve issues and ensure timely processing
• Communicate effectively with suppliers on purchase orders and issue resolution
• Track PO status and manage follow-ups for delivery and invoicing
• Support supplier onboarding activities
• Maintain procurement records and ensure adherence to controls
• Support process improvement initiatives

Associate Buyer, Procurement – Finance

Director

• Monitors state legislation and regulatory activities, updating and advising on relevant policy proposals and actions, and working with the cross-functional teams to analyze potential impacts to Definium
• Develop and execute strategies to shape state policy that delivers on enterprise priorities. This includes developing/executing strategic initiatives and policy positions, drafting written comments, analysis of complex health care policies, direct lobbying, engagement of third-party groups and coalitions
• Develop both a proactive and reactive policy agenda to create new frameworks to support Definium’s pipeline
• Assess public policy environment, determine where legislative and regulatory action is advisable and where it is not, and make recommendations on Definium action
• Demonstrate and maintain strong working relationships with key state and regional stakeholders that may develop health care policies that could impact Definium
• Build stakeholder partnerships and advocacy coalitions that advance mental health awareness, patient access, and policy priorities while strengthening Definium's leadership across the healthcare ecosystem
• Develop close working relationships with key internal cross functions stakeholders to leverage advocacy strategies. Engage with these key business stakeholders and develop keen understanding of commercial strategies to ensure public policy strategies support Definium’s commercial and regulatory objectives

Director, State Government Affairs

• Develop and implement stakeholder engagement strategies for relevant external audiences
• Develop and execute communication plans that clearly convey the real-world value of the company’s products
• Cultivate and maintain relationships with key health care decision-makers and influencers, including U.S. payers, academic institutions, key opinion leaders, health system providers, and policy stakeholders
• Contribute to the development of integrated evidence generation plans by identifying and collecting field-generated real-world data insights to fulfill evidence gaps
• Partner closely with internal functions—including Clinical Development, Clinical Operations, Policy, Commercial, Market Access, and Medical Affairs—to develop and/or support programs that address broad product access and demand challenges
• Partner with health system providers, practices, and site of care delivery teams to support site readiness and operationalization of patient care sites, including facilitating access to healthcare economic data, reimbursement pathways, practice economics analyses, and patient services resources that enable successful practice adaption
• Contribute to account planning with cross-functional field-based teams, identifying areas where value and healthcare economic information can be collected or utilized to support patient access
• Support and/or deliver the presentation of disease related information, and healthcare economic information to health care decision makers
• Represent the company at key national and international conferences

Senior Director, Field VEOR

Cloud Engineer

• Design deploy maintain optimize and automate scalable secure and resilient cloud infrastructure and solutions across Azure GCP and AWS
• Manage backup and disaster recovery strategies across cloud platforms
• Implement and maintain robust cloud security controls aligned with industry standards CIS NIST and ISO 27001
• Implement and maintain Infrastructure as Code cloud automation and CI CD driven deployments
• Support cloud automation initiatives including infrastructure automation integrations operational workflows and platform stability improvements
• Enable AI and intelligent automation use cases in alignment with established governance and security standards
• Troubleshoot cloud platform issues support incident resolution and maintain technical documentation and runbooks
• Help define and enforce cloud governance standards including management groups subscriptions Azure Policy RBAC naming conventions tagging and cost controls
• Implement automation in ServiceDesk identity and other enterprise platforms to drive consistent efficient and rapid experiences
• Engage with IT and functional stakeholders to define business processes align them to appropriate technology solutions and represent Definium technology interests on initiatives with significant technology impact
• Translate functional and technical requirements into solution architecture and provide build and deployment guidance to software developers
• Design scalable supportable systems by selecting technology stacks that can be supported by a broad ecosystem of providers and technically skilled Definium staff
• Identify and evaluate technology partners and maintain relationships with strategic vendors to stay informed of evolving capabilities and risks
• Stay current on leading and emerging technologies and evaluate fit against financial security and operational requirements
• Cross train and mentor junior engineers

Senior Cloud Engineer

Affiliate Manager

• Act as the primary IT point of contact for Commercial and Medical Affairs leadership, developing strong, trust‑based partnerships
• Understand the Commercial and Medical Affairs strategy, business goals, and operational challenges, aligning business objectives to clear, prioritized IT initiatives and requirements
• Support systems and new product introduction by providing technical expertise, system administration, problem solving, and strategies for risk mitigation
• Support the overall governance and lifecycle management of commercial and Medical Affairs systems and platforms. (e.g., Veeva Vault CRM, Open Data, Link, Approved Email)
• Lead requirements gathering, documentation, and testing for commercial and Medical Affairs platforms. Ensure configuration, enhancement, and expansion of the systems aligns with broader organizational data standards, information security practices, and regulatory needs
• Work closely with IT and Legal to ensure data protection controls such as segmentation and access boundaries are designed, implemented, and consistently enforced in alignment with regulatory requirement
• Ensure alignment between business demand and IT capacity and prioritization
• Provide oversight and system administration across SaaS platforms supporting Commercial operations and Medical Affairs. (e.g., CRM, field enablement, analytics, content management)
• Ensure solutions are scalable, user‑centric, and aligned with enterprise architecture standards
• Monitor delivery risks, dependencies, and change impacts; escalate as appropriate Serve as a clear communicator between technical and non‑technical stakeholders
• Drive change management, user adoption, and ongoing optimization of deployed solutions.

IT System Business Partner – Commercial and Medical

Marketing

• Develop and execute medical marketing initiatives that support the scientific positioning and successful commercialization of DT120
• Lead KOL engagement strategy, including identification, segmentation, relationship development, and ongoing engagement planning
• Manage advisory board planning and execution, including objectives, attendee selection, content development, logistics, and insight capture
• Support medical congress strategy and execution, including sponsorships, exhibits, symposia, scientific communications, and stakeholder engagement activities
• Partner with Medical Affairs, Clinical Development, Commercial, and Regulatory teams to align scientific engagement activities with broader organizational objectives
• Direct external agency partners and vendors supporting congresses, advisory boards, speaker programs, and scientific communications initiatives
• Gather and synthesize insights from KOL interactions, advisory boards, congresses, and market intelligence to inform brand and evidence-generation strategies
• Support development of scientific communication materials and engagement initiatives that strengthen awareness, credibility, and launch readiness

Associate Director, Medical Marketing

Digital Marketing

• Develop and execute patient / consumer marketing strategies and annual brand plans to support the successful launch and commercialization of DT120
• Manage key patient marketing initiatives across the product lifecycle, including pre-launch planning, audience segmentation, campaign execution, performance measurement, and optimization
• Drive digital patient engagement strategy, including branded and unbranded web experiences, CRM, social media, search, and other non-personal promotional initiatives
• Oversee the promotional review process (MLR/PRC) to ensure all patient-facing marketing materials are compliant with regulatory requirements
• Partner with Medical Affairs, Market Access, Patient Services, Sales, and cross-functional commercial teams to align patient engagement strategies with broader business objectives
• Direct external agency partners across creative, digital, media, analytics, and market research to deliver high-impact, ROI-driven initiatives within budget
• Translate patient, caregiver, and market insights into actionable strategies that strengthen engagement, differentiation, and launch readiness
• Support patient advocacy, congress, and community engagement initiatives that enhance awareness, education, and brand presence

Associate Director, Patient & Digital Marketing

Human Resources

• Manage new hire onboarding by sending welcome emails, adding hires to the HRIS, assigning onboarding tasks and forms, coordinating first-week orientation, and maintaining the new hire tracker
• Support Talent Acquisition processes by partnering with recruiters to post jobs, confirm position details, format job descriptions, and audit descriptions for compliance and consistency
• Assist with offer letters and ensure all details are accurate and consistent
• Manage external job postings and the pre-employment processes by initiating and monitoring background checks, reviewing results, and tracking pre-boarding requirements and activities
• Deliver a positive, consistent candidate experience at every touchpoint
• Support departmental administrative needs, including travel, expense reporting, meeting coordination (individual and group meetings), swag inventory, documentation requests, and electronic filing
• Support HR budget processes by setting up vendors, creating purchase orders, tracking expenses, and coordinating with Finance to ensure timely invoice processing and accurate reporting
• Support HR related trainings and workshops, such as education sessions for managers, leadership coffee chats, and new hire sessions, by coordinating logistics, preparing materials, tracking attendance, administering surveys, enabling remote participation, and assisting with event planning for conferences and job fairs

Senior Human Resources Coordinator

Engineer

• Provide operational support for remote staff. This will include hardware and software issues
• Create, update, triage, and close support tickets in the Definium ITSM to ensure a thorough documentation of requests and incidents, end-user communication, root cause analysis and resolution
• IT lead for all new and departing employee responsibilities. Ensure compliance with all on-boarding and off-boarding policies and procedures
• Coordinate the hardware lifecycle for remote employees from procurement, configuration, collection, and retirement
• Provide primary/secondary system administration to IT systems
• Work closely with IT MSPs and professional service providers
• Assist in identifying, evaluating, justifying, and deploying, new products, technologies, systems, services, and workflows
• Independently perform actions under departmental change control procedures with minimal oversight or assistance
• Ensure compliance for technology projects and processes including Sarbanes Oxley (SOX), 21 CFR Part 11, cGxP, and GDPR
• Author and review standard operating procedures and knowledge-based articles for the maintenance and operation of software applications
• Ensure that best practices for the service and support of technology products are documented and followed
• Stay up to date on industry trends and best practices