Natera

Machine Learning Engineer

• Lead the technical design and deployment of multi-agent systems capable of autonomous hypothesis generation and tool use
• Incorporate and advance Natera’s transformer-based foundation model
• Implement advanced LLM reasoning frameworks
• Architect systems that autonomously translate complex, multi-modal data into diagnostic and therapeutic insights
• Own the technical strategy and product roadmap for agentic workflows

Staff Machine Learning Scientist

• Provide technical leadership at the intersection of deep learning, computational biology, and molecular diagnostics.
• Drive the architecture and validation of genomic, transcriptomic, and multimodal sequence models.
• Engineer alignment and post-training workflows based on clinical trial and molecular diagnostic data.
• Lead parameter-efficient fine-tuning (PEFT) and evaluation of deep sequence and multimodal models.
• Validate model outputs against benchmarks and real-world outcomes.
• Collaborate with cross-functional teams to translate clinical requirements into machine learning problem statements.
• Act as a technical bridge between AI Research and ML Engineering teams.
• Author technical manuscripts for peer-reviewed venues and represent the company's capabilities at conferences.

Staff Machine Learning Scientist, Translational AI

Customer Support

• Conduct proactive outreach to patients following testing to provide support, education, and resource navigation.
• Engage patients through phone, SMS, email, and other approved communication channels while delivering a positive and professional customer experience.
• Educate patients on testing processes, available resources, patient portal tools, scheduling options, and other relevant support services.
• Gather patient feedback regarding their testing experience and document insights that help improve patient programs and services.
• Identify and help address common barriers to care, including scheduling challenges, provider communication needs, access to resources, and general process questions.
• Provide patients with approved educational materials, discussion guides, and support resources.
• Coordinate with Patient Coordinators, field teams, provider offices, and other internal stakeholders to support patient needs.
• Escalate clinical, billing, technical, or service-related concerns to the appropriate internal teams.
• Maintain accurate documentation of all patient interactions and follow-up activities within Salesforce and other internal systems.
• Support outreach initiatives, patient education programs, and operational projects designed to improve the overall patient experience.
• Maintain compliance with all privacy, regulatory, and communication requirements.
• Demonstrate empathy, professionalism, and sound judgment when interacting with patients and caregivers.

Patient Outreach and Support Specialist – Temp

Analyst

• Drive collaboration and coordination with cross-functional teams, including programmers, engineers, and management.
• Track team progress and deliver detailed status reports, including KPIs and performance data.
• Participate in CAPA reviews to identify training and process improvement opportunities.
• Support patient-focused teams with quality improvement, tracking, and performance projects.
• Create and maintain documentation such as SOPs and protocols.
• Partner with management and data analysts to identify new process improvement opportunities.
• Audit call and email communications to assess quality and accuracy; compile QA feedback summaries for management and training teams.
• Follow established protocols when delivering feedback to Patient Experience agents and leadership.

Patient Experience QC Analyst

Operations

• Serve as the physician-facing point of medical contact for ordering providers, applying clinical judgment to resolve questions and concerns that require a physician's perspective.
• Provide medical leadership to the internal teams that support ordering physicians, translating clinical context into operational decisions.
• Lead the development and optimization of physician onboarding and ordering workflows to ensure a seamless ordering experience for physicians.
• Identify and address clinical and operational barriers that impact physician adoption, utilization, and retention.
• Partner with Medical Affairs, Laboratory, and commercial cross-functional teams to improve end-to-end clinical and operational processes.
• Provide medical oversight and guidance for clinical experience initiatives and operational improvement projects.
• Analyze physician ordering patterns, operational metrics, and physician feedback to identify opportunities for process improvement.
• Serve as a senior clinical and operational resource to ordering physicians for complex clinical questions and escalations.
• Translate physician insights and operational challenges into actionable recommendations for Medical Affairs and business leadership.
• Drive initiatives to improve specimen quality, turnaround times, ordering efficiency, and the overall quality of the physician ordering experience.
• Evaluate and address challenges that contribute to provider attrition, including clinical friction, workflow inefficiencies, and ordering obstacles.

Director, Medical Operations

Manager

• Responsible for the implementation of clinical trial activities per study protocol. Works closely with investigative site personnel, CROs, and other study vendors.
• Manage and coach clinical research staff.
• Manage study contracting, budget and payment process for all clinical trial vendors including investigational sites.
• Partner with department head to develop department procedures and develop infrastructure.
• Design study related documents, including but not limited to study protocol, informed consent forms, CRFs, and regulatory binders.
• Train CROs, vendors, investigators and study coordinators on study protocol and relevant material.
• Monitor and track clinical trial progress and provide status update to stakeholders.
• Partner with other research and development groups to achieve deliverables.

Senior Manager, Clinical Trials

Clinical Research

• Responsible for the implementation of clinical trial activities per study protocol.
• Works closely with investigative site personnel, CROs, and other study vendors.
• Manage study contracting, budget and payment process for all clinical trial vendors including investigational sites.
• Design study related documents, including but not limited to study protocol, informed consent forms, CRFs, and regulatory binders.
• Train CROs, vendors, investigators and study coordinators on study protocol and relevant requirement.
• Monitor and track clinical trial progress and provide status update to stakeholders.
• Partner with other research and development groups to achieve deliverables.
• Mentor junior clinical operations staff and supervise clinical study team.
• This role works with PHI on a regular basis both in paper and electronic form and have an access to various technologies to access PHI (paper and electronic) in order to perform the job.

Senior Clinical Trial Manager

• Manage the execution and conduct of all aspects of very complex clinical studies to ensure that timelines, cost, and quality metrics are met.
• Responsible for selection of vendors/CROs and provide effective ongoing management to vendors/CROs working on the project to ensure compliance and execution of project deliverables.
• Manage study contracting, budget, forecasting, accruals and payment process for all clinical trial vendors including investigational sites.
• Lead study-related activities such as protocol and informed consent preparation, investigator selection, study training material development and delivery.
• Collaborate with Clinical Data Management group to ensure correct CRFs content is collected, prepare comprehensive completion guidelines, and design effective data listings and study reports.
• Train CROs, vendors, investigators and study coordinators on implementation of study protocol.
• Hire, train, manage and oversee Clinical trial staff, and serve as a resource for others within the company for clinical trials management expertise.
• Monitor and track clinical trial progress and provide status update to stakeholders.
• Support sample management and prospective sample testing for studies where Natera functions as a central testing facility.
• Partner with other research and development groups to create a culture of mutual respect and focus on delivery of high-quality project results.
• Develop Clinical Department SOPs and participate in audits as needed.

Manager, Clinical Trials

Data Engineer

• Lead the vision, strategy, and roadmap for Natera’s health system data sharing initiatives, including platforms that integrate Natera’s genomic data with health system clinical data to enable advanced analytics, clinical insights, and operational intelligence.
• Identify and prioritize high-value opportunities for secure data exchange, interoperability, and analytics across health systems, including use cases that support clinical decision-making, research, and population health.
• Collaborate with engineering, data science, and design teams to define product requirements (PRDs, user stories, user flows) and deliver scalable, high-quality data platform, analytics, and AI-driven insights solutions.
• Develop products and user experiences that enable clinicians and health systems to derive insights and actions from combined genomic and clinical datasets, including dashboards, workflow integrations, and AI-assisted recommendations.
• Evaluate and integrate third-party technologies (e.g., data interoperability frameworks, analytics platforms, and AI/ML tools) to accelerate development and improve performance.
• Develop and track success metrics (e.g., adoption, data utilization, clinical impact, performance, and partner satisfaction) to measure impact and identify continuous improvement opportunities.
• Partner with health system stakeholders, clinical informatics teams, and business leaders to ensure seamless integration into clinical workflows and EMR ecosystems.

Senior Product Manager, Health Systems Data Platforms

Artificial Intelligence

• Review oncology patient records to determine whether cases meet clinical and payer policy requirements.
• Serve as an escalation point for complex cases that cannot be accurately classified by AI workflows.
• Analyze challenging clinical scenarios, including patients with multiple cancer diagnoses, complex treatment histories, and ambiguous documentation.
• Document findings and recommendations within internal systems including Salesforce, LIMS, and other workflow tools.
• Ensure accuracy and consistency of clinical review outcomes.
• Perform ongoing audits of AI-generated clinical determinations and data classifications.
• Evaluate AI performance against established clinical review standards.
• Identify errors, trends, and opportunities to improve automation accuracy.
• Participate in validation activities for new AI models, workflows, and clinical review processes.
• Provide structured feedback to improve future AI performance.
• Partner with Product, Engineering, and Data Science teams to improve clinical AI capabilities.
• Help define clinical decision logic and requirements used in AI-driven workflows.
• Translate clinical review findings into actionable recommendations for automation improvements.
• Support testing and implementation of new AI-enabled solutions.
• Contribute to the long-term evolution of Natera's oncology clinical intelligence platforms.
• Develop expertise in payer coverage policies relevant to our Signatera product and oncology testing.
• Evaluate clinical documentation against coverage requirements.
• Assist in identifying cases that may require additional clinical review or reimbursement support.
• Stay current on evolving oncology standards, treatment pathways, and reimbursement trends.

Clinical Review RN, Oncology AI Review

Product Manager

• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives.
• Influence platform-level technical direction in partnership with engineering leadership.
• Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams.
• Translate business, clinical, and operational needs into clear, actionable product requirements.
• Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality.
• Drive cross-team alignment on shared data contracts and workflow standards.
• Mentor and raise the bar for product management within the RIR organization.
• Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability.
• Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments.
• Develop and track quantitative metrics related to usability, performance, reliability, and adoption.
• Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability.
• Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them.
• Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems.
• Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making.
• Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use.

Senior Product Manager, Clinical Genomics

Translator

• Build, scale, and lead a specialized team of field-facing translational scientists.
• Author and execute the regional data engagement strategy.
• Oversee secure regional tracking architecture and data ingestion pipelines.
• Command the interface between field operations and internal leadership.
• Manage lifecycle of all regional investigator-initiated trials (IITs) and institutional registries.
• Secure and manage institutional data-sharing models and biobanking initiatives.
• Represent Natera as a senior scientific authority at major oncology congresses.

Director, Field Translational Science – Oncology

• Monitor claim status activity across clearinghouses and payer systems to ensure claims are successfully transmitted, received, and processed.
• Analyze large claim populations to identify trends, bottlenecks, acceptance issues, and payer-specific workflow challenges.
• Investigate rejected, unacknowledged, delayed, or "stuck" claims and determine root causes.
• Partner with Billing Operations, Insurance Verification, Denials Management, Coding, Configuration, Engineering, and Automation teams to resolve claim processing issues.
• Identify opportunities to automate manual claim status workflows and improve operational efficiency.
• Serve as a subject matter expert on clearinghouse operations, payer connectivity, claim submission workflows, EDI transactions, and claim status processes.
• Research payer-specific requirements, acceptance rules, rejection patterns, and status behaviors.
• Develop recommendations for workflow improvements that increase claim acceptance rates and reduce downstream denials.
• Track and trend claim status performance metrics and communicate findings to operational leadership.
• Support implementation and optimization of automation solutions related to claim status management and payer communications.
• Create process documentation, job aids, and operational guidance to support standardized workflows.
• Assist with escalation management and complex claim routing decisions.
• Collaborate with internal and external stakeholders to identify systemic issues and implement sustainable corrective actions.

EDI & Claims Operations Analyst

• Lead the technical design and deployment of multi-agent systems capable of autonomous hypothesis generation and tool use, including genomic variant calling, LLM fine-tuning, and clinical trial matching pipelines
• Incorporate and advance Natera’s transformer-based foundation model by integrating DNA, RNA, and H&E imaging modalities for multi-step biological reasoning and tool use
• Implement advanced LLM reasoning frameworks, such as ReAct and Chain-of-Thought, alongside reinforcement fine-tuning (RFT) to ensure agents provide accurate, explainable clinical rationales
• Architect systems that autonomously translate complex, multi-modal data into diagnostic and therapeutic insights with human-verifiable reasoning and tracing
• Own the technical strategy and product roadmap for agentic workflows across the Biopharma Solutions and Therapeutics Discovery division, converting complex clinical challenges into scalable AI systems
• Establish production-grade machine learning engineering standards and reproducible architectures across the AI team to ensure absolute model transparency and scientific auditability
• Drive cross-functional alignment and technical consensus by defending agentic architectures and biological reasoning frameworks in rigorous peer reviews

Senior Machine Learning Scientist, Agentic AI

• Provide timely and accurate information to international customers and internal teams via phone, email, and other electronic channels
• Manage high volume of international customer accounts and their support needs
• Resolve customer inquiries and issues promptly and communicate the resolution clearly and logically. Troubleshoot the issue and identify the root cause
• Partner with Sales team counterparts to follow-up on missing information needed to process and report ordered tests
• Document all customer interactions, communications, actions taken, and follow ups in our customer service applications
• Collaborate with internal teams such as sales, product development, and lab operations to ensure customer needs are met effectively
• Coordinate with logistics and shipping teams to resolve any shipping, customs, or delivery issues related to kits or samples
• Provide training and educational support to our internal teams and customers on test ordering processes
• Stay updated on the latest company products, services, and processes (including samples required, test turnaround time, required order information, required waivers, etc…) to offer the best support
• Track and report common customer issues, providing feedback for process improvements or product enhancements
• Lead or support special projects and other duties as required to meet business needs
• Assist in testing upgrades to and development of new customer service tools
• Stay current with Natera training requirements and assist with mentoring and training new employees on international support processes
• Note this role works with PHI on a regular basis both in paper and electronic form and has access to various technologies to access PHI (paper and electronic) to perform the job