Sr Director, US Patient Advocacy
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Senior Director, Health Economics and Outcomes Research / Real-World Evidence
Amylyx Pharmaceuticals
full-time
Posted on:
Origin: • 🇺🇸 United States • Massachusetts
Visit company websiteJob Level
Senior
About the role
- Report to the SVP of Medical Affairs and lead the HEOR function
- Build and lead the HEOR function including the development of integrated HEOR and evidence generation strategies and tactical plans to support Amylyxs therapeutic programs
- Lead evidence gap analyses to inform HEOR strategic and tactical plans and lead cross-functional data generation and communication planning efforts
- Design and execute projects such as burden of illness, real-world clinical outcomes, clinical registries, retrospective database analyses, and meta-analyses
- Provide scientific support for protocol development, target product profiles, data collection strategies, literature review and evidence synthesis
- Oversee stakeholder engagement and communication, including peer-reviewed publications, conference presentations, and internal communication of HEOR findings
- Support global market access strategy including early scientific advice with HTA agencies, regulatory support, and preparing for global HTA models
- Ensure HEOR tactics are aligned cross-functionally with business strategies and regulatory guidelines and monitor and interpret U.S. policy changes
- Collaborate with Market Access and Medical Affairs to develop and maintain evidence packages tailored to U.S. payers (commercial, Medicare, Medicaid)
- Lead vendor selection and manage external research partners; build and manage a team for real-world evidence generation and health economics research
- Manage HEOR budget planning and resource allocation to ensure efficient execution of strategic priorities
Requirements
- 10+ years healthcare or pharmaceutical industry experience with minimum 7 in HEOR
- Masters Degree (MS, MPH, PharmD, PhD) in a relevant discipline (e.g., health economics, medicine, pharmacy, public health, epidemiology) required
- Demonstrated success in designing and leading real-world research to support US payer value and access
- Experience supporting HEOR strategy for product launch, including pre-launch evidence generation and payer engagement, is highly desirable
- Deep understanding of U.S. healthcare system dynamics, including payer structures, value-based care, and regulatory trends
- Excellent leadership and cross-functional collaboration skills, with the ability to influence and drive strategy across teams and with external partners and vendors
- Excellent analytical skills, including in-depth knowledge of COAs and pharmacoeconomic modeling and retrospective database analysis methodologies
- Experience working with U.S. claims databases, EMRs, and patient registries; proficiency in RWE analytics platforms and methodologies
- Knowledge of endocrine and/or obesity space a plus
- Ability to travel up to 20%
