Research Scientist

• Leading the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
• Designing and executing experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high‑resolution slide imaging and sequencing.
• Establishing and refining new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
• Building and scaling laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
• Managing CROs and external partners, ensuring high‑quality data generation, timeline alignment, and technical deliverables.
• Collaborating closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
• Contributing to data workflows by supporting early-stage data mapping, QC frameworks, and analytical handoffs to computational teams.

Principal Scientist, Spatial Omics

• Assist with coordination of research projects
• Perform day-to-day research project activities such as recruitment database searches, mailings, and recruitment calls
• Schedule research appointments, maintain study documentation, manage specimen tracking and data collection
• Conduct and manage minimal risk studies under supervision
• Prepare, maintain, and track regulatory documents according to governmental regulations
• Assist with subject visits including obtaining vital signs, performing clinical tests, and data collection
• Set-up, track, and trouble-shoot study technology

Research Assistant

• Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
• Contributing to guide modeling and simulation strategies within the organization.

Senior Principal Scientist, Preclinical Safety – Translational Pharmacokinetics/Pharmacodynamics

• The incumbent is responsible for leading complex research and technology development programs, defining technical strategy, designing and developing process cycles, designing experiments, analyzing results, and translating learnings into improved heat exchanger designs, engineering methods, and commercial offerings.
• This is a senior individual contributor research process engineering role with a focus on process cycle and new technology development for the LNG industry.
• The role requires a creative and innovative approach, strong chemical engineering fundamentals, and the ability to influence across R&D, product management, process engineering, commercial, and operations teams.
• The candidate will be expected to solve complex and ambiguous technical problems involving two-phase fluid flow, gas separation, heat transfer, thermodynamics, heat exchanger design, and cryogenic equipment performance.
• This position involves up to 10% travel to domestic and global locations.

Senior Advanced R&D Engineer, Scientist

• Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
• Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
• Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
• Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
• Present scientific strategies and recommendations to senior leadership and governance committees.
• Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
• Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
• Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
• Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
• Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
• Provide scientific mentorship and leadership across matrix teams.
• Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

Senior Principal Scientist, Aging and Metabolism

• Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
• Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
• Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
• Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
• Present scientific strategies and recommendations to senior leadership and governance committees.
• Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
• Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
• Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
• Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
• Serve as a subject matter expert, ensuring scientific rigor, quality, reproducibility, and translational relevance across programs.
• Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
• Provide scientific mentorship and leadership across matrix teams.
• Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

• develop a research agenda and lead/conduct research in support of critical U.S. government needs
• lead novel research in applied machine learning and robotics
• lead interdisciplinary teams to turn research results into prototype operational capabilities for government customers and stakeholders
• actively participate with researchers, developers, engineers, designers, technical leads, campus labs, and government customers to understand challenges, needs, and potential solutions
• mentor and teach junior staff, lead technical sessions, and contribute to the establishment of technical norms for the Lab
• maintain awareness of the latest in AI-enabled autonomous systems, especially pertaining to National Security use cases
• develop and deliver compelling technical presentations for diverse audiences, tailor content for varied stakeholders, speak at conferences and workshops, and publish in pertinent peer-reviewed journals

Senior Autonomy Systems Research Scientist

• Ensure each medicine GSK brings to market is supported by scientifically credible, high quality evidence.
• Plan, design, and execute multiple studies for a given asset and manage timelines, deliverables, and budget.
• Assure quality of deliverables, including review and sign off project specifications, protocols, data analysis plans, final study reports, abstracts, posters and manuscripts.
• Identify resources, references and analyses to inform scientific design and advise internal experts as needed in support of the asset team.
• Translate needs for evidence into study concepts in alignment with strategic objectives and vision for the asset.
• Develop and maintain a good working knowledge of real-world data resources, existing partnerships and public initiatives.
• Develop a deep understanding of customers’ needs, including clinicians and HTA requirements, and their acceptance of different types of evidence and impact of that evidence to their decision making.
• Collaborate with internal teams and participate in best practice sharing sessions across the non-interventional study organization.
• Build strong working relationships with internal stakeholder groups across medical, market access, R&D and commercial.
• Ensure key stakeholders are regularly updated on plans through periodic reporting.
• Develop excellent working relationships with external thought leaders to ensure appropriate methods and research agendas are applied.

Director, Global Real-World Evidence & Health Outcomes Research – Hematology-Oncology

• Partner cross-functionally with the Value Chain Team (VCT) and manufacturing sites owning the coordination of technical activities to ensure manufacturing and supply demands are met
• Lead and Execution of technical projects that will enhance manufacturing output through optimization and harmonization across production sites
• Your efforts will have a direct impact on patient supply!
• Lead improvement and innovation initiatives includes building project business case; partner with R&Dsite functions and finance to identify COGS improvement opportunities (COGS optimization process)
• Author, review and approval of product technical and regulatory documents (e.g., protocols, reports, filings, criticality analysis, control strategies, master plans, etc.)
• Lead the development of technical, quality, & compliance risk assessments/mitigation strategies and possible business continuity plans
• Act as Process SME: proactively monitor technical process and product performance to detect trends and develop mitigation plans
• Maintain a robust technical support network related to lifecycle management, new technologies, automation, comparability, change management and tech transfers for product

MSAT Principal Scientist

• Research, analyze, and write reports on policy topics on terrorism, extremism, hate, and other threats to Hindu Americans.
• Utilize software platforms and discern sources to ensure high-quality research.
• Find, collect, input and collate data across databases, information sources, survey responses, and other data sources; ensures data quality; clean existing data for consistency and accuracy.
• Develop data visualizations for diverse audiences.
• Prepare reports, charts, and/or graphs for briefs and presentations that synthesize complex topics for lay audiences.
• Provide research, writing, analysis, and proofreading support to the Policy Department for the creation of policy briefs, fact sheets, reports, articles, speeches, presentations, and other documents.
• Provide additional logistical support as needed for the Policy Research Department.

Policy Research Fellow

• Serve as the scientific and strategic leader between Therapeutic Discovery & Supply (TDS) and Discovery teams.
• Enable seamless end‑to‑end decision‑making for biologics programs and technical platforms.
• Proactively identify and mitigate development risks during the discovery phase.
• Ensure that structural, biophysical, expression, and developability insights are assessed and effectively integrated into Chemistry, Manufacturing and Controls (CMC) strategies and program planning.
• Identify early opportunities to assess knowledge gaps to derisk program development.
• Lead platform alignment efforts to ensure data and decisions are translatable across discovery and development.
• Build out knowledge management and sharing systems to integrate knowledge across the teams.

Distinguished Scientist, Biologics Discovery, Process Research Integrator

• Serve as the scientific and strategic leader between Therapeutic Discovery & Supply (TDS) and Discovery teams
• Enable seamless end‑to‑end decision‑making for biologics programs and technical platforms
• Identify and mitigate development risks during the discovery phase
• Ensure that structural, biophysical, expression, and developability insights are effectively integrated into CMC strategies and program planning
• Identify early opportunities to assess knowledge gaps to derisk program development
• Lead platform alignment efforts to ensure data and decisions are translatable across discovery and development
• Provide deep scientific guidance on molecule selection, engineering, developability, manufacturability, expression, and protein structure–function considerations
• Build trusted cross‑functional partnerships and influencing decision‑making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS

Distinguished Scientist, Biologics Discovery

• Set technical direction for core replenishment R&D — define the modeling roadmap across demand forecasting, inventory optimization, and decision-making policy, and align it with product and business strategy.
• Model complex problems such as inventory decay, promotions, price elasticity, and inventory uncertainty, and implement solutions to multi-stage and multi-echelon inventory optimization problems.
• Drive fundamental changes to our core system from research through production, writing rigorously tested and scalable code.
• Lead research and development for new product and business challenges.
• Raise the technical bar across the Intelligence team: mentor scientists and engineers, set standards for experimental rigor, and review designs and results.
• Push the boundaries of AI capabilities in both products and scientist workflows.

Staff Applied Scientist – Distribution Center

• Lead end-to-end AI applications on trial imaging data (CT, MRI, PET) for quantitative imaging measures and AI-derived endpoints
• Collaborate internally and externally to drive scientific innovation in foundational imaging AI that are relevant to oncology drug development — including automated segmentation, radiomics, and multimodal predictive modeling through hands-on research
• Translate imaging-derived evidence into actionable insights by converting complex quantitative findings into clear scientific narratives and engaging cross-functional stakeholders
• Provide scientific leadership to external partnerships — including imaging AI vendors, CROs, biomarker companies, academic centers, and imaging OEMs — to accelerate model development, validation, and deployment
• Publish and present scientific innovation at top scientific and clinical conferences (e.g., MICCAI, AACR, RSNA, etc.)

Principal Scientist, Imaging Analytics

• Lead end-to-end AI applications on trial imaging data (CT, MRI, PET) for quantitative imaging measures and AI-derived endpoints.
• Collaborate internally and externally to drive scientific innovation in foundational imaging AI that are relevant to oncology drug development — including automated segmentation, radiomics, and multimodal predictive modeling through hands-on research.
• Translate imaging-derived evidence into actionable insights by converting complex quantitative findings into clear scientific narratives and engaging cross-functional stakeholders.
• Provide scientific leadership to external partnerships — including imaging AI vendors, CROs, biomarker companies, academic centers, and imaging OEMs — to accelerate model development, validation, and deployment.
• Publish and present scientific innovation at top scientific and clinical conferences (e.g., MICCAI, AACR, RSNA, etc.)

• Leads value evidence teams and develops value evidence strategies for in-line and pipeline products.
• Obtains senior management approval of evidence generation plans.
• Provides outcomes research leadership on cross-functional regional and global teams.
• Critically assesses drivers and barriers to reimbursement and market access, and provides input into clinical, regulatory, payer/access, marketing and evidence generation strategies and programs.
• In collaboration with internal teams and external partners, designs studies, authors study protocols, develops measurement questionnaires, case report forms, data analysis plans, final study reports, scientific presentations, and publications.
• Responsible for study-related contracting, budgets, and vendor/partner management and to ensure study conduct is aligned with company Policies and SOPs and world-wide regulations and standards, including Good Pharmacoepidemiology Practice (GPP) for applicable work.
• Develops American Managed Care Pharmacy (AMCP) dossiers for US payers, and Global Value Dossiers for use by local subsidiaries in their local HTA submissions.
• Develops supplementary clinical data package in close partnership with markets and HTA statistics group for submission to HTA agencies.
• Supports country affiliates to understand local evidence generation needs, adapts health economic evaluations, customizes outcomes research documents, such as protocols and reimbursement dossiers, according to local requirements.
• Works closely with cross-functional teams to effectively communicate outcomes research and health economic modelling data internally and to external stakeholders.
• Maintains awareness of new scientific and methodological developments within therapeutic area.
• Builds relationships with scientific experts worldwide.
• Presents outcomes research data at national and international congresses and publishes articles in scientific journals.

Principal Scientist – Rheumatology Outcomes Research

• Set technical direction for core replenishment R&amp;D.
• Model complex problems such as inventory decay, promotions, price elasticity, and inventory uncertainty.
• Drive fundamental changes to our core system from research through production.
• Lead research and development for new product and business challenges.
• Mentor scientists and engineers, set standards for experimental rigor.

Staff Applied Scientist

• developing, maintaining, and implementing Core Labeling and target labeling for assigned products in line with internal standards and guidelines
• Developing, maintaining, and implementing US Labeling for assigned products in line with regulatory requirements and internal standards and guidelines
• Assisting with developing and maintaining Local Labeling (EU and most of world) for assigned products
• Providing labeling expertise and guidance to teams, assimilating labeling precedence and competitor labeling, while ensuring compliance with applicable regulatory requirements
• Serving as regulatory labeling point of contact on global Regulatory Affairs sub-teams to ensure delivery of labeling documents that meet quality and compliance standards and regulatory labeling requirements to support timely regulatory submissions for assigned products
• Leading (both direct reports and cross-functional teams) to develop, review and approve Core and Local Labeling documents
• Independently recommending strategies and labeling language for inclusion in Core or Local Labeling during labeling development or responses to Health Authority
• Providing information to Global Labeling Compliance, as required, to support internal and external (i.e., Regulatory Authority) requirements and support audits/inspections as a labeling subject matter expert
• Evaluating risks associated with Core or Local Labeling content, developing mitigation strategies, and appropriately escalating issues to Global Labeling management and the Global Regulatory team
• Proficiency in crucial labeling requirements worldwide
• Contributing to the continuous improvements to the end-to-end labeling process, including labeling policies, procedures, quality, and system tools
• Providing guidance, coaching, training and may provide management support to other Global Labeling Leads

Principal Scientist – Global Labeling Lead

• Lead a team in the development and execution of health economic and modeling strategies to support the value of the Company’s oncology portfolio
• Provide leadership, mentorship, and strategic direction to a team of 3–4 health economists
• Oversee the prioritization and development of high-quality global health economic models and tools to support market access, pricing, reimbursement, HTA submissions, and formulary decision-making across U.S. and international markets
• Collaborate with key countries and the regional team to adapt global models for local HTA, reimbursement, and formulary submissions
• Generate and communicate early health economic insights to inform development and commercialization strategies
• Build strong partnerships with internal stakeholders to ensure modeling strategies align and support the overall product development and value evidence strategy and implementation
• Develop and maintain relationships with external thought leaders in health economics, decision sciences, and health policy to enhance scientific credibility, inform strategy, and position our company as a leader in the field

Research Scientist jobs in Pennsylvania

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Principal Scientist, Spatial Omics

Research Assistant

Senior Principal Scientist, Preclinical Safety – Translational Pharmacokinetics/Pharmacodynamics

Senior Principal Scientist, Preclinical Safety – Translational Pharmacokinetics/Pharmacodynamics

Senior Advanced R&D Engineer, Scientist

Senior Principal Scientist, Aging and Metabolism

Senior Principal Scientist, Aging and Metabolism

Senior Autonomy Systems Research Scientist

Director, Global Real-World Evidence & Health Outcomes Research – Hematology-Oncology

MSAT Principal Scientist

Policy Research Fellow

Distinguished Scientist, Biologics Discovery, Process Research Integrator

Distinguished Scientist, Biologics Discovery

Staff Applied Scientist – Distribution Center

Principal Scientist, Imaging Analytics

Principal Scientist, Imaging Analytics

Principal Scientist – Rheumatology Outcomes Research

Staff Applied Scientist

Principal Scientist – Global Labeling Lead

Senior Principal Scientist, Outcomes Research