Senior Principal Scientist, Aging and Metabolism

Johnson & Johnson

Senior Principal Scientist leading translational pharmacology activities for aging and metabolism. Driving scientific strategies and collaboration in biotech innovation for age-related diseases.

Posted 7/18/2026full-timeSpring House • Massachusetts, Pennsylvania • 🇺🇸 United StatesSenior💰 $137,000 - $235,750 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in translational pharmacology, integrating disease biology, pharmacology, and clinical data to drive scientific strategy and decision-making. Proven leadership in target validation, assay development, and collaboration with multidisciplinary teams in the pharmaceutical and biotechnology sectors.

Highest-signal resume keywords

Ph.D. In PharmacologyIn Vitro PharmacologyTarget ValidationReceptor PharmacologyBiomarker Development

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Hard Skills

Assay DevelopmentMechanism-Of-Action StudiesTranslational ResearchPharmacokinetics/Pharmacodynamics (PK/PD)Cell SignalingBiologicsMulti-Specific AntibodiesPeptide TherapeuticsGene-Silencing TechnologiesTargeted Delivery Platforms

Soft Skills

Excellent Verbal CommunicationExcellent Written CommunicationStrategic ThinkingLeadershipCollaboration

Industry Keywords

Aging BiologyMetabolismObesityCardiovascular DiseaseHeart FailureTranslational MedicineCRO CollaborationExternal Innovation EvaluationScientific MentorshipMatrix Environment

About the role

Key responsibilities & impact

Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
Present scientific strategies and recommendations to senior leadership and governance committees.
Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
Serve as a subject matter expert, ensuring scientific rigor, quality, reproducibility, and translational relevance across programs.
Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
Provide scientific mentorship and leadership across matrix teams.
Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

Requirements

What you’ll need

A minimum of a Ph.D. in Pharmacology, Physiology, Cell Biology, Molecular Biology, Biochemistry, Biomedical Sciences, or a related scientific discipline is required.
A minimum 10 years of pharmaceutical or biotechnology experience is required.
Demonstrated experience in the following is required: in vitro pharmacology; target validation; assay development; mechanism-of-action studies; translational research.
Strong knowledge of the following is required: receptor pharmacology; GPCR biology; cell signaling; biomarkers; PK/PD; translational medicine.
Experience in the following is preferred: muscle biology; aging biology; metabolism; obesity; cardiovascular disease; heart failure.
Experience supporting the following is preferred: biologics; multi-specific antibodies; peptide therapeutics; RNA-based medicines; gene-silencing technologies; targeted delivery platforms.
Experience evaluating external innovation and business development opportunities is preferred.
Proven ability to provide leadership within multidisciplinary drug discovery teams is required.
Must have excellent verbal and written communication skills.
Must be strategic with a strong scientific mindset.
The ability to operate effectively within a highly coordinated, fast-paced matrix environment is required.

Benefits

Comp & perks

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company’s long-term incentive program.
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
10 days Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year