Senior Principal Scientist, Preclinical Safety – Translational Pharmacokinetics/Pharmacodynamics

Johnson & Johnson

Senior Principal Scientist applying pharmacokinetic modeling for project decision-making in drug development at Johnson & Johnson. Collaborating on studies from discovery to early clinical phases.

Posted 7/21/2026full-timeSpring House • California, Pennsylvania • 🇺🇸 United StatesSenior💰 $137,000 - $235,750 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Expertise in Pharmacokinetic and Pharmacodynamic modeling, with a strong foundation in mathematical modeling and simulation. Proven ability to contribute to project team decisions and guide modeling strategies in early clinical studies.

Highest-signal resume keywords

PharmacokineticsPharmacodynamicsMathematical ModelingSimulationPeer-Reviewed Publications

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

PK/PD ModelingMathematical ModelingSimulation TechniquesData AnalysisStatistical Methods

Soft Skills

Interpersonal SkillsOrganizational SkillsOral CommunicationWritten CommunicationTeamwork

Industry Keywords

PharmacologyEngineeringMathematicsPhysicsClinical Studies

About the role

Key responsibilities & impact

Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
Contributing to guide modeling and simulation strategies within the organization.

Requirements

What you’ll need

Education: PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 6+ years of relevant industry experience OR a Master's degree with 8+ years of relevant industry experience is required.
Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred.
Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications is highly desired.
Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.

Benefits

Comp & perks

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period10 days
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year