Karyopharm Therapeutics Inc.

Account Executive

• Develop and lead the Karyopharm partnership with multiple key contacts across all accounts
• Identify opportunities to leverage Karyopharm products across market segments, both directly and indirectly
• Plan, initiate, negotiate and manage profitable business relationships and contracts with assigned accounts
• Develop and execute account specific business plans and provide ongoing business updates to Market Access team and other internal partners
• Manage and maximize internal resources, both financial and human, in meeting planned objectives with each customer
• Ensure compliance with all applicable laws, regulations, and guidelines
• Work collaboratively with Market Access colleagues and multiple functional areas in developing strategic and tactical plans
• Participate and assist in the planning of overall brand and corporate strategies on an ongoing basis and as part of various sub-teams and committees as needed
• Be viewed as the subject matter expert on assigned accounts, market segments, and issues that impact our relationship and ability to work with them
• Manage administrative and fiduciary duties as appropriate to the CAD role

Clinical Account Director – CAD

Director

• Own the U.S. EC brand strategy and multi-year commercial roadmap; deliver an annual Brand Plan/AOP with clear objectives, KPIs, milestones, and investment choices aligned to franchise and corporate priorities.
• Define and evolve positioning, message platform, and customer value proposition; translate clinical and real-world evidence into differentiated, compliant claims and communications.
• Lead lifecycle planning and strategic scenario work (e.g., competitive response, biomarker-driven opportunities, combination strategies, line-of-therapy expansion opportunities, and treatment sequencing dynamics), partnering with cross-functional leaders to evaluate options and trade-offs.
• Drive U.S. EC launch strategy and readiness from pivotal data readout through launch execution, defining launch milestones, critical path, and cross-functional workstreams.
• Develop customer segmentation and targeting strategy across key stakeholders, including gynecologic oncologists, medical oncologists, academic cancer centers, community oncology practices, integrated delivery networks, and key accounts.

Senior Director, Endometrial Cancer Brand Lead

Manager

• Leads the strategy, administration, governance, and continuous improvement of Benefits, HRIS, and related HR operations in alignment with business objectives.
• Oversees health and welfare, retirement, leave, disability, wellness, and voluntary benefits programs, including plan design, renewals, benchmarking, open enrollment, and employee communications.
• Manages broker, carrier, retirement plan, COBRA, FSA/HSA, leave administration, HRIS, and other vendor relationships, including contracts, service levels, escalations, budgets, purchase orders, and compliance deliverables.
• Ensures compliance with applicable benefits and employment requirements, including ERISA, ACA, COBRA, HIPAA, Section 125, FMLA, ADA, required filings, notices, plan documents, Forms 5500, ACA reporting, nondiscrimination testing, audits, SOPs, and documentation retention.
• Provides guidance to employees and managers on benefits, leave administration, HR policies and procedures, HRIS, employee data, and HR operational best practices.
• Oversees HRIS data integrity, reporting, employee records, workflows, system security, access controls, confidentiality protocols, and audit readiness.
• Leads HRIS configuration, enhancements, integrations, testing, release management, and employee self-service tools to support scalable HR processes.
• Develops HR metrics and uses AI-enabled tools, people analytics, and workforce data insights to improve operational efficiency, automate processes, support workforce planning, and enhance the employee experience.
• Partners with Payroll, Finance, Accounting, IT, Legal, Quality, and external partners on benefits deductions, payroll integrations, budgeting, invoice reconciliation, accruals, cost analysis, and related operational needs.
• Supports onboarding, offboarding, Inclusion & Wellness initiatives, and related employee communications through accurate eligibility administration, HRIS updates, planning, and execution.
• Leads, coaches, and develops Benefits and HRIS team members while promoting collaboration, responsiveness, confidentiality, data accuracy, and continuous improvement.

Senior Manager, Benefits, HRIS

People Operations

• Leads and oversees the employee onboarding and offboarding experience in partnership with key stakeholders
• Partners with HR leadership to develop and execute strategic People Operations initiatives aligned with business objectives
• Oversees employee recognition and engagement programs to support a positive and inclusive company culture
• Manages and enhances onboarding programs, including onboarding agendas and the new hire buddy program
• Ensures compliance with employment eligibility verification requirements and oversees all I-9 documentation processes
• Provides guidance to employees and managers regarding HR policies, procedures, and best practices
• Collaborates cross-functionally with IT, Payroll, Facilities, Administration, Quality, Legal, and other teams to ensure operational effectiveness
• Oversees HRIS data integrity, reporting, employee records management, onboarding and offboarding documentation, and audit readiness
• Drives process improvement initiatives and implements scalable operational efficiencies across HR workflows and procedures
• Manages vendor relationships related to background checks, immigration, employment verifications, HR systems, and other HR operational services
• Partners with HR Centers of Excellence during key annual processes, including performance reviews, compensation planning, succession planning, and engagement surveys
• Oversees legal contract coordination, budget tracking, and purchase order processing for the HR function
• Assists and manages immigration processes for new and existing employee cases in partnership with external counsel and internal stakeholders
• Partners with Compensation and Finance teams to support equity administration and organizational planning processes
• Collaborates with HR leadership to execute strategic Human Resources initiatives and change management activities
• Leads the review and maintenance process to ensure all job descriptions are accurate, compliant, and aligned with organizational structure
• Facilitates new hire orientation sessions and supports leadership development and employee training initiatives
• Oversees offboarding activities, including separation documentation, benefits communications, exit interviews, and risk mitigation activities
• Partners with Payroll to ensure accurate and timely payroll-related documentation and processing
• Supports Inclusion & Wellness initiatives and programs through strategic planning, communication, and execution
• Leads HR compliance activities related to GxP training records, audit readiness, SOP management, and documentation retention requirements
• Partners with Talent Acquisition and hiring managers to support workforce planning, hiring operations, and onboarding activities
• Leverages AI-driven tools, HR analytics, and workforce data insights to enhance operational efficiency, support strategic decision-making, improve employee experience, and drive continuous process improvement across the HR function
• Develops and analyzes HR metrics and reporting related to turnover, headcount, engagement, and operational performance
• Leads the adoption and governance of AI-enabled HR technologies and people analytics to optimize workforce planning, operational effectiveness, and employee engagement strategies
• Acts as a trusted advisor to managers and employees on employee relations matters, organizational changes, and HR operational practices
• Ensures compliance with federal, state, and local employment laws, including leave administration, accommodations, and policy administration

Senior Manager, People Operations

• Lead the development and implementation of sales force strategies, including targeting, field team sizing, and incentive compensation plans
• Guide and develop analytics for all commercial activities and departments
• Foster a culture of continuous learning and professional development, while mentoring team members
• Leverage data and insights to clearly communicate the health of the business
• Design and implement field operation needs, such as CRM, power BI reporting, and targeting lists
• Maintain the highest standards in commercial data, reporting, and analytics
• Collaborate closely with various functional stakeholders to ensure cross-functional alignment
• Manage relationships with data vendors, ensuring the quality of final products
• Support the development of the company's Data Warehouse and reporting capabilities
• Develop and implement weekly, monthly, and quarterly dashboards

Director – Strategic Analytics & Reporting

General Counsel

• Partnering cross-functionally to provide legal advice related to Marketing and Market Access, including brand strategy, promotional materials, and patient support initiatives
• Partnering with Medical Affairs to advise on strategy, scientific exchange, and field medical materials
• Fostering a culture of compliance in Karyopharm’s interactions with healthcare professionals, including development of policies and delivery of effective training initiatives
• Providing legal advice as a member of cross-functional teams including product development program teams, promotional and medical review committees, and grant and investigator-sponsored trial review committees
• Communicating legal advice to business stakeholders in an authentic and understandable way

Clinical Account Director – CAD

Senior Director, Endometrial Cancer Brand Lead

Senior Manager, Benefits, HRIS

Senior Manager, People Operations

Director – Strategic Analytics & Reporting

Executive Director, Brand Counsel