Encoded Therapeutics Inc.

Director

• Drive the development and execution of the integrated US Medical Affairs strategy, ensuring alignment between clinical development and commercial launch requirements.
• Design US Field Medical strategy and planning, defining engagement models and territory mapping across US treatment centers, as well as performing field-based engagement and research, as needed.
• Remain at the forefront of gene therapy science and the competitive landscape to inform internal strategy and external positioning. Provide clinical and competitive insights to shape launch needs and market entry.
• Cultivate and maintain deep professional relationships with US Key Opinion Leaders (KOLs), healthcare professionals, and industry experts to exchange scientific knowledge, identify clinical trial opportunities, and understand commercial needs.
• Represent Encoded at major medical congresses, advisory boards, and investigator meetings, presenting complex data with clarity.
• Collaborate closely with Scientific Communications to ensure medical messages, publication plans, and educational materials are scientifically rigorous and strategically aligned with US regulatory standards.
• Work in lockstep with Patient Advocacy to ensure the patient voice is integrated into clinical trial design and commercial planning.
• Support development of a comprehensive US HEOR and outcomes research plan to support market access, PBM negotiations, and reimbursement.
• Partner with Clinical and HEOR teams to design evidence generation activities, including Investigator Sponsored Studies (ISS) and observational research to support regulatory approval and endpoint validation.
• Partner with Commercial, Regulatory, and Clinical to ensure a seamless transition from development to market.
• Lead US-specific initiatives, including payer/HTA research and value messaging, launch roadmaps, and center of excellence and patient journey mapping to ensure development of approaches that address the unique opportunities and challenges of gene therapy.
• Develop and manage long-range budget forecasts and oversee vendors to ensure timely delivery of US medical materials.

Senior Director, US Medical Affairs

• Strategic planning and implementation: Define and lead the global HEOR roadmap for ETX101, ensuring that strategies drive creation of a strong value story for ETX101 to optimize payer and HTA engagement in alignment with clinical, regulatory and commercial readiness timelines and plans.
• Integrated evidence generation: Serve as a key internal expert supporting design of Encoded’s clinical development program to maximize their utility both for regulatory authorities and payers. Design and execute specific studies, including burden-of-illness (BOI; clinical, humanistic, economic), real-world evidence, and patient preference studies. Support development and/or validation of clinically meaningful outcome measures. Oversee development of cost-utility analyses and budget impact modelling.
• Stakeholder engagement: Partner with clinical experts, the patient community, HTA bodies/payers, and other external collaborators to disseminate accurate information across channels, including publications, congresses, and symposia.
• Operational excellence: Manage vendor selection, budgets, and resource allocation for complex HEOR projects, ensuring timely completion and, in concert with Scientific Communications, high-impact delivery of abstracts, posters, and manuscripts.
• Cross-functional support: Contribute to or lead other cross-functional initiatives, as needed, including Medical Affairs, Market Access and Commercial activities (e.g. payer/HTA research, value messaging, launch roadmaps, and CoE and patient journey mapping) to ensure development of innovative approaches that address the unique opportunities and challenges of gene therapy.
• Travel domestically and internationally, as required.

Senior Director, Global HEOR, Evidence Generation

Communications

• - Drive publication planning and development of abstracts, posters, and manuscripts in collaboration with cross-functional teams and external partners.
• - Partner with internal stakeholders including Clinical Development/Sciences, Biometrics, and Corporate Communications to ensure timely, high-quality communication of data and insights from ongoing studies. Maintain internal and external processes for document review, approval, and version control across publication and communication deliverables.
• - Develop and maintain accurate, scientifically sound materials such as slide decks, message platforms, FAQs, and lexicon documents for both internal and external audiences.
• - Support preparation of scientific narratives, conference presentations, and data visualizations that align with company strategy and compliance standards.
• - Ensure excellence in visual and written presentation of complex data to external audiences, including medical and patient communities, regulatory authorities, investors, and Encoded’s Board of Directors.
• - Partner on the planning and execution of scientific congress activities, including session coverage, data presentations, booth materials, and internal debrief summaries. Attend conferences and cover sessions, participate in KOL and patient meetings, and staff conference tables/booths as needed.
• - Assist in the coordination of advisory boards and expert meetings, supporting agenda development, scientific content, and post-meeting reports.
• - Work closely with Research, Clinical Development, Corporate Communications, Regulatory Affairs, Patient Advocacy, and Commercial teams to ensure consistency of medical messaging across programs and audiences.
• - Manage Medical–Legal–Regulatory (MLR) review of external documents for the MPA team.
• - Manage reactive Patient Advocacy and Medical Information enquiries with timely, compliant, empathetic responses.
• - Support Patient Advocacy Organization engagement, including participating in meetings, preparing regular update communications, and developing simple educational materials.
• - Support development, management, and communication of health economics and outcomes research (HEOR) projects, as needed.
• - Manage and collaborate with vendors and external medical writers to deliver projects on time, within scope, and in alignment with company standards.
• - Ensure publications adhere to Encoded’s Publication Policies and Authorship Guidelines; Good Publication Practice (GPP) guidelines; the International Committee for Medical Journal Editors Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals; and any other relevant conference, journal, legal or regulatory guidelines, as appropriate.
• - Travel internationally & domestically as required.

Associate Director – Scientific Communications

Security Engineer

• Building upon Encoded’s foundations, enhance and mature our systems, people and processes to support
• Provide broad cybersecurity, IT operations and service delivery leadership and expertise.
• Develop and maintain cybersecurity and operations roadmaps aligned with business objectives and milestones.
• Provide leadership and technical oversight to help IT service desk, operations, infrastructure and security team members deliver on service levels, projects and commitments.
• Drive efficiency and scalability initiatives
• Partner with internal and vendor resources to perform IT security assessments, vulnerability scanning,
• network penetration testing, and incident response plan testing to ensure the organization has addressed
• vulnerabilities, implemented effective security controls, and prepared responses to threats.
• Keep current on emerging threats and technology.
• Oversee Encoded’s cybersecurity training program.
• Develop, refine and test policies and procedures, including Incident Response and Disaster Recovery
• Direct the technical elements of Encoded’s data privacy and data security programs
• Perform data security and privacy vendor assessments
• Oversee system access review activities, collect audit evidence, maintain documentation and monitor
• security controls to support audits.
• Report regularly to senior management on security activities, incidents, and remediation.
• Influence and mobilize users across the organization to take action to protect Encoded’s data and
• embrace a security-first mindset
• Refine existing operations and identify areas where Encoded can streamline and improve operational
• efficiency.
• Direct the infrastructure change management program.
• Serve as a technical escalation point for complex/sensitive issues.
• Communicate changes to processes, policies and systems across the organization
• Provide oversight of telecom and A/V services.

Senior Director, US Medical Affairs

Senior Director, Global HEOR, Evidence Generation

Associate Director – Scientific Communications

Director, IT Operations – Security