Encoded Therapeutics Inc.

Operations

• Partner with the VP, People & Culture and the Board's Compensation Committee to design and implement scalable, market-competitive executive and broad-based incentive structures appropriate to a maturing organization.
• Partner with Finance on the design and market-competitiveness of the equity program - including grant guidelines, benchmarking grant levels against market, and the evaluation of future equity vehicles (e.g., an ESPP).
• Own compensation benchmarking and market analysis, including Radford survey submissions and the maintenance of job architecture, salary structures, and pay bands.
• Run the total rewards calendar end to end - merit and bonus planning, mid-year and year-end compensation cycles, and the compensation components of the performance process.
• Serve as the subject-matter expert on pay equity, compensation philosophy, and total rewards communications to managers and employees.
• Lead the evolution of Encoded's HR operations and service-delivery model, including assessing and, where appropriate, transitioning HR technology, payroll, and benefits delivery to support the company's scale.
• Own the HR technology roadmap and serve as system owner for the HR tech stack, with a focus on integration across HRIS, payroll, benefits, and downstream systems.
• Own vendor management for key People partnerships - benefits brokers, leave-of-absence providers, HRIS and payroll vendors, and compensation survey providers - including selection, contracting, and performance management.
• Oversee the annual operational compliance cycle, including 401(k) plan audit, ACA reporting, Section 125 / FSA non-discrimination testing, and EEO-1 reporting.
• In partnership with Finance, build and maintain internal controls and data integrity over HR and payroll data that meet the standards of a maturing, audit-ready organization, and ensure data integrity through audit cycles.
• Develop and maintain readiness for evolving compensation, governance, and disclosure requirements; coordinate the external advisors (compensation consultants, counsel) and Finance partners who support these needs.

Director, Total Rewards – Operations

Data Scientist

• Serve as the primary, hands-on Data Manager for multiple clinical studies, driving the daily data flow, performing discrepancy management, and conducting granular data review activities.
• Own or co-own external data reconciliation as a standardized cross-study workstream. Reconcile complex datasets from multiple external vendors with the EDC and internal systems; meticulously track, document, and resolve discrepancies to ensure an easy-to-audit framework.
• Review Tables, Figures, and Listings (TFL) specifications and listings to ensure they are fully supported by the clinical data collected. Partner directly with statisticians to investigate document trails and aggressively resolve data mismatches.
• Write, QC, and execute User Acceptance Testing (UAT) plans and test scripts, specifically for databases, CRFs, and data review tools/systems. Capture and archive objective evidence during UAT to ensure compliance.
• Author and QC system- and data-related documentation. Maintain a flawlessly traceable audit trail—ensuring clear documentation of where files are stored, how they are versioned, and how they will present to a systems or validation inspector.
• Partner with Clinical and Biometrics to draft comprehensive Data Management Plans (DMPs), eCRF specifications, completion guidelines, and data transfer agreements.
• Manage technical deliverables and data flows from contracted CDM vendors, ensuring all activities meet strict corporate timelines and quality thresholds.

Clinical Data Manager

• Serve as the Clinical Data Manager for assigned studies and/or lead specific, specialized data management workstreams (e.g., manual data review, external vendor data management) across multiple studies within a clinical program
• Participate in protocol and amendment reviews of assigned studies or program workstreams to ensure optimal CRF design and cross-study data standardization
• Partner with Clinical and Biometrics to develop or contribute to comprehensive Data Management Plans and Data Review Plans, covering all aspects of data collection, processing, reconciliation, review, and archival for the assigned scope
• Lead or support the design and build of the clinical databases and review tools to ensure they support clinical study objectives
• Responsible for user acceptance testing (UAT) within assigned study scopes or workstreams, including authoring and/or executing scripts
• Oversee or execute assigned aspects of data collection and review, which may include: monitoring data flow, performing discrepancy management, leading and participating in data review or reconciliation activities, and planning/facilitating database lock
• Manage timelines for assigned CDM activities to support corporate and clinical program objectives.
• Ensure complete, accurate and inspection-ready CDM documentation within the assigned scope
• Ensure all CDM documentation are complete, accurate and inspection-ready state.
• Act as team SME for key data systems and data streams, and process enhancement efforts
• Contribute to program deliverable timeline creation
• Performs additional duties as assigned

Business Operations

• Partner with clinical operations, data management, and biometrics teams to author Request for Proposals (RFPs) and define vendor scopes of work.
• Lead cross-functional bid defense meetings, analyze commercial proposals, perform cost benchmarking, and provide data-driven recommendations to leadership.
• Drive the strategic selection of CROs and specialized clinical vendors, optimizing the vendor portfolio for quality, scalability, and cost-efficiency.
• Partner with Legal and the clinical development team in the drafting, negotiation, and final execution of Master Services Agreements (MSAs), Statements of Work (SOWs), Change Orders and confidentiality agreements across clinical functions.
• Design, author, and standardize SOW templates to streamline vendor onboarding, establish baseline metrics, and reduce execution cycle times.
• Manage the negotiation and execution of Clinical Trial Agreements (CTAs) and investigator budgets for sponsor-managed sites, ensuring rapid study startup.
• Manage an active change order management pipeline to rigorously track contract amendments, budget shifts, and vendor performance.
• Partner closely with study teams to proactively identify operational deviations from the original SOW, mitigating scope creep before it impacts the budget.
• Liaise between Clinical Operations and Corporate Finance to ensure financial alignment across all programs.
• Partner with the Head of Clinical Operations to build robust, multi-year clinical trial budget forecasts, lifecycle cost models, and annual operational plans.
• Support quarterly Budget vs. Actual (BVA) reviews; track investigator grant accruals and vendor pass-through costs, and accurately explain financial variances to leadership.
• Identify operational gaps and implement scalable business processes, tools, templates, and governance mechanisms to improve efficiency, transparency, compliance, and organizational effectiveness.
• Support due diligence, alliance management, and business development activities as needed.
• Champion a culture of accountability, operational rigor, collaboration, and continuous improvement across the Clinical organization.

Director, Total Rewards – Operations

Clinical Data Manager

Clinical Data Manager

Associate Director, Clinical Business Operations