Clinical Data Manager

Encoded Therapeutics Inc.

Clinical Data Manager overseeing data management activities for gene therapy clinical programs. Collaborating with cross-functional teams to ensure high-quality clinical trial data delivery.

Posted 6/18/2026full-timeSouth San Francisco • California • 🇺🇸 United StatesMid-LevelSeniorWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Serve as the Clinical Data Manager for assigned studies and/or lead specific, specialized data management workstreams (e.g., manual data review, external vendor data management) across multiple studies within a clinical program
Participate in protocol and amendment reviews of assigned studies or program workstreams to ensure optimal CRF design and cross-study data standardization
Partner with Clinical and Biometrics to develop or contribute to comprehensive Data Management Plans and Data Review Plans, covering all aspects of data collection, processing, reconciliation, review, and archival for the assigned scope
Lead or support the design and build of the clinical databases and review tools to ensure they support clinical study objectives
Responsible for user acceptance testing (UAT) within assigned study scopes or workstreams, including authoring and/or executing scripts
Oversee or execute assigned aspects of data collection and review, which may include: monitoring data flow, performing discrepancy management, leading and participating in data review or reconciliation activities, and planning/facilitating database lock
Manage timelines for assigned CDM activities to support corporate and clinical program objectives.
Ensure complete, accurate and inspection-ready CDM documentation within the assigned scope
Ensure all CDM documentation are complete, accurate and inspection-ready state.
Act as team SME for key data systems and data streams, and process enhancement efforts
Contribute to program deliverable timeline creation
Performs additional duties as assigned

Requirements

What you’ll need

BS/BA and/or MS degree Bachelor’s degree or equivalent combination of education/experience in science or health-related field with 4 years of direct data management experience (Rare disease experience highly desirable)
Strong knowledge of CDM processes, EDC systems (Medrio and Medidata RAVE preferably), database programming, and quality management
Understanding of the MedDRA and WHODRUG coding processes.
Knowledgeable in GCP standards, CDISC standards (CDASH, SDTM, ADaM), FDA and ICH guidelines, and recommended CDM Best Practices
Outstanding problem-solving abilities and influencing/negotiation skills
Excellent interpersonal, communication, and leadership skills
Logical thinking, attention to detail and accuracy, good organizational skills, and problem-solving abilities
Ability to prioritize and adapt quickly to changing business conditions with a positive attitude
Willing to travel if required

Benefits

Comp & perks

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time, and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Fitness center

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

clinical data managementdata management plansuser acceptance testingdatabase programmingdata collectiondiscrepancy managementdatabase lockdata reviewquality managementEDC systems

Soft Skills

problem-solvinginfluencing skillsnegotiation skillsinterpersonal skillscommunication skillsleadership skillslogical thinkingattention to detailorganizational skillsadaptability