Clinical Data Manager

Encoded Therapeutics Inc.

Clinical Data Manager responsible for executing clinical data management activities for gene therapy programs. Ensuring data integrity and compliance for clinical development at Encoded Therapeutics.

Posted 7/13/2026full-timeRemote • California • 🇺🇸 United StatesMid-LevelSenior💰 $95,000 - $135,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical data management, including data reconciliation, discrepancy management, and documentation authoring, while ensuring compliance with GCP and CDISC standards. Proficient in managing data flows and technical deliverables from external vendors in a clinical study environment.

Highest-signal resume keywords

Clinical Data ManagementEDC Systems (Medrio, Medidata RAVE)Data ReconciliationUser Acceptance Testing (UAT)GCP Standards

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Data CleaningDataset ReconciliationDocumentation AuthoringDatabase Programming ConceptsData Review Tools

Soft Skills

Organizational SkillsAttention to DetailProactive Approach

Industry Keywords

CDISC Standards (CDASH, SDTM)MedDRA CodingWHODRUG CodingFDA GuidelinesICH Guidelines

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Serve as the primary, hands-on Data Manager for multiple clinical studies, driving the daily data flow, performing discrepancy management, and conducting granular data review activities.
Own or co-own external data reconciliation as a standardized cross-study workstream. Reconcile complex datasets from multiple external vendors with the EDC and internal systems; meticulously track, document, and resolve discrepancies to ensure an easy-to-audit framework.
Review Tables, Figures, and Listings (TFL) specifications and listings to ensure they are fully supported by the clinical data collected. Partner directly with statisticians to investigate document trails and aggressively resolve data mismatches.
Write, QC, and execute User Acceptance Testing (UAT) plans and test scripts, specifically for databases, CRFs, and data review tools/systems. Capture and archive objective evidence during UAT to ensure compliance.
Author and QC system- and data-related documentation. Maintain a flawlessly traceable audit trail—ensuring clear documentation of where files are stored, how they are versioned, and how they will present to a systems or validation inspector.
Partner with Clinical and Biometrics to draft comprehensive Data Management Plans (DMPs), eCRF specifications, completion guidelines, and data transfer agreements.
Manage technical deliverables and data flows from contracted CDM vendors, ensuring all activities meet strict corporate timelines and quality thresholds.

Requirements

What you’ll need

BS/BA or MS degree in a scientific, health-related, or computational field with 4+ years of direct, hands-on clinical data management experience (Emerging biotech or growth-stage company environment strongly preferred).
Demonstrated expertise managing the tactical day-to-day lifecycle of clinical data, including extensive data cleaning, multi-vendor dataset reconciliation, and comprehensive documentation authoring.
Strong technical proficiency with EDC systems (Medrio and Medidata RAVE preferred), database programming concepts, and data review tools.
Experience with the review, reconciliation, and cleaning of complex external datasets (e.g., biomarker, genomic, imaging, longitudinal data) as well as neurodevelopmental, behavior, and motor assessments.
Demonstrated ability to write and QC UAT plans and scripts while systematically archiving objective validation evidence.
Solid understanding of GCP standards, CDISC standards (CDASH, SDTM), MedDRA/WHODRUG coding, and FDA/ICH guidelines.
Exceptional organizational skills, an obsession with detail/accuracy, and a proactive approach to closing compliance gaps.

Benefits

Comp & perks

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time, and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Fitness center at our S. San Francisco location