Eli Lilly and Company

Associate Vice President – Methods4Insight

Eli Lilly and Company

full-time

Posted on:

Location Type: Hybrid

Location: San Francisco • California • Colorado • United States

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Salary

💰 $259,500 - $380,600 per year

About the role

  • Serve as the strategic leader for analytical methods across Data Foundry, maintaining deep awareness of cutting-edge approaches in cheminformatics, computational structural biology, statistical modeling, mathematical physics, and AI/ML, and establishing Methods4Insight as the authoritative source for guidance on analytical approaches to discovery challenges.
  • Build and maintain a portfolio of analytical capabilities spanning classical methods to cutting-edge AI—including QSAR/QSPR modeling, molecular docking, free energy calculations, molecular dynamics, Bayesian experimental design, active learning, deep learning, and generative models—ensuring the right approach is matched to each scientific question.
  • Make strategic build-versus-buy-versus-adopt decisions for analytical capabilities, balancing speed of adoption with need for customization, and collaborating with leading analytical teams across Lilly to ensure best practices are shared.
  • Proactively identify strategic “data deserts”—areas where Lilly lacks sufficient data to answer critical questions—and develop strategies to fill these gaps through targeted in silico modeling or high-throughput experimental data generation, prioritized by scientific impact and strategic value.
  • Establish rigorous frameworks for evaluating and validating analytical methods, including prospective validation protocols and impact metrics that demonstrate decisions influenced, timelines accelerated, and experimental success rates improved.
  • Collaborate closely with the Frontier AI group to ensure analytical methods are designed as “agent-ready” capabilities with well-defined APIs, structured inputs/outputs, error handling, and uncertainty quantification for use by autonomous AI agents.
  • Collaborate closely with Architecture4Insight, Scale4Insight, and Preparedness4Insight to ensure Methods4Insight analytical capabilities are fully integrated across all Data Foundry pillars and the broader discovery ecosystem.
  • Build and lead a team of domain experts, each recognized as a thought leader in their analytical specialty, fostering a culture of intellectual curiosity, continuous learning, and innovation.
  • Champion a culture of scientific rigor, reproducibility, and continuous improvement across all analytical workflows.

Requirements

  • Ph.D. in Cheminformatics, Computational Biology, Biophysics, Applied Mathematics, Computer Science, Statistics, or related quantitative field with strong application to drug discovery
  • 15+ years of experience developing, evaluating, and deploying analytical methods for drug discovery, with significant pharmaceutical or biotechnology industry experience
  • Deep expertise in at least one analytical domain with broad understanding across all domains relevant to drug discovery
  • Deep understanding of statistical foundations underlying both classical and modern ML methods
  • Demonstrated thought leadership through publications, conference presentations, or other recognition as a domain expert
  • Demonstrated success leading multidisciplinary computational teams in a matrixed, global organization
  • Breadth across multiple computational disciplines demonstrating versatility and ability to integrate approaches
  • Experience evaluating and adopting external methods, tools, and platforms—demonstrating ability to critically assess new approaches
  • Strong communication and collaboration skills across scientific, technical, and executive stakeholders
  • Track record of driving innovation in analytical methods and enabling new scientific capabilities
  • Passion for mentoring and empowering teams in a fast-paced, mission-driven environment.
Benefits
  • eligibility to participate in a company-sponsored 401(k)
  • pension
  • vacation benefits
  • eligibility for medical, dental, vision, and prescription drug benefits
  • flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
  • life insurance and death benefits
  • certain time off and leave of absence benefits
  • well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
cheminformaticscomputational structural biologystatistical modelingmathematical physicsAI/MLQSAR/QSPR modelingmolecular dockingfree energy calculationsmolecular dynamicsBayesian experimental design
Soft Skills
thought leadershipteam leadershipcollaborationcommunicationmentoringinnovationintellectual curiositycontinuous learningscientific rigorreproducibility
Certifications
Ph.D. in CheminformaticsPh.D. in Computational BiologyPh.D. in BiophysicsPh.D. in Applied MathematicsPh.D. in Computer SciencePh.D. in Statistics