Director/Sr. Director/Exec. Director, Computational Chemistry – Advanced Molecular Design
Eli Lilly and Company
full-time
Posted on:
Location Type: Hybrid
Location: San Francisco • California • Colorado • United States
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Salary
💰 $193,500 - $338,800 per year
Job Level
About the role
- Structure-based design efforts for the lead/late-stage optimization of small molecule therapeutics across a range of therapeutic areas
- Play a key role in prioritizing medicinal chemistry efforts through critical analysis and effective decision-making leading to highly focused work and rapid progress
- Ensure the timely delivery of data and results to project teams to enable rapid iterative design cycles
- Maintain critical timelines and set team expectations for efficient delivery of clinical candidates
- Contribution to decision-making at higher levels, up to and including prioritization of our overall small-molecule discovery portfolio
- Work closely with other AMD and therapeutic area leaders to move our portfolio of molecules from leads to quality drug candidates that have a strong potential to become breakthrough drugs
- Contribute to the ongoing evaluation of external technologies and related business development opportunities
Requirements
- PhD in Chemistry, Biophysics or related discipline with 6 -15 years of Drug Discovery research experience
- A deep scientific background in computational chemistry technology to guide compound optimization for medicinal chemists
- Proven ability to collaborate across disciplines to achieve project goals and timelines
- Proactive and effective collaboration with medicinal chemists, structural biologists, and other disciplines to achieve project goals and timelines
- A commitment to mentoring earlier career computational chemists
- Strong core desire to help patients in need
- Proven track record of success in drug discovery
- Deep-thinking that leads to creative hypotheses for the optimization of lead series across multiple projects
- A strong desire to establish a deeper understanding of all aspects of drug discovery, including small molecule-protein interactions, ADME, and toxicological considerations
- A proactive and highly engaged approach to solving challenging problems in discovery is essential
- A desire to continually stay up to date with the latest industry developments and novel techniques employed in discovery including AI and machine learning models
- Deep knowledge of lead optimization using structure-based design and other aspects of computational chemistry
- Agility and adaptability to change research priorities as necessary for success
Benefits
- eligibility to participate in a company-sponsored 401(k)
- pension
- vacation benefits
- eligibility for medical, dental, vision and prescription drug benefits
- flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
- life insurance and death benefits
- certain time off and leave of absence benefits
- well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
computational chemistrydrug discoverylead optimizationstructure-based designsmall molecule therapeuticsADMEtoxicological considerationsAImachine learning
Soft Skills
collaborationdecision-makingmentoringproblem-solvingproactive engagementcritical analysiseffective communicationadaptabilitydeep thinking
Certifications
PhD in ChemistryPhD in Biophysics