Amgen

Scientific Associate Director – PKDM, Small Molecule ADME

Amgen

full-time

Posted on:

Location Type: Hybrid

Location: South San Francisco • California • United States

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Salary

💰 $216,073 - $255,336 per year

Job Level

Senior

About the role

  • Oversee biotransformation activities and serve as a project team representative focused on small molecule (SM) programs.
  • Characterize the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK) properties of SM therapeutic drug candidates.
  • Serving as a subject matter expert of small molecule biotransformation and leading biotransformation activities.
  • Leverage current biotransformation knowledge and develop novel tools to efficiently support biotransformation activities.
  • Collaborate with scientists across the PKDM scientific community.
  • Plan and execute mechanistic ADME/PK analyses to optimize dose selection and preclinical study designs.
  • Contribute to the analysis of pre-clinical ADME and PK data for IND and NDA filings and document these analyses.

Requirements

  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of directly related experience
  • Or Master’s degree and 7 years of directly related experience
  • Or Bachelor’s degree and 9 years of directly related experience
  • PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training
  • Candidate should have solid technical experience with the application of SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects
  • Ability to drive the progression of SM discovery and development within project teams
  • Establish SM biotransformation and ADME workflows for PKDM scientists.
  • Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK
  • Experience in supporting preclinical components of regulatory documentations.
  • Excellent interpersonal, technical, and communication skills to lead cross-functional teams
  • Past experience as a laboratory scientist in a pharma or biotech environment
  • Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills
  • Record of scientific contributions through peer-reviewed articles and external presentations.
Benefits
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models, including remote and hybrid work arrangements, where possible
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
biotransformationADMEpharmacokineticsin vitro ADMEin vivo ADMEPK/PDPBPKdrug discoverymechanistic analysespreclinical study design
Soft Skills
interpersonal skillscommunication skillsattention to detailaccuracyleadershipcollaborationtechnical skillsproblem-solvingproject managementteamwork
Certifications
PhDPharmDMD