Associate Director, Clinical Pharmacology Lead

Pfizer

Associate Director leading Clinical Pharmacology within Pfizer's Internal Medicine portfolio. Collaborating on innovative drug development strategies with a focus on clinical pharmacology principles.

Posted 4/14/2026full-timeCambridge • Connecticut, Massachusetts, New York • 🇺🇸 United StatesSenior💰 $124,400 - $207,400 per yearWebsite

About the role

Key responsibilities & impact

Act as Clinical Pharmacology representative on Clinical Sub Team and Development Team and other multifunctional teams as appropriate
Responsible for providing expertise, leadership, and deliverables of clinical pharmacology for the assigned projects within sphere of influence
Design and execute clinical pharmacology plans and implement clinical pharmacology best practices on project teams
Work closely with other disciplines to ensure that sufficient preclinical PK/PD knowledge exists to underwrite safe human administration and to establish the structure of a predictive model prior to FIH
Responsible for planning and overseeing clinical pharmacology aspects at the project level (e.g clinical development plan, implementation and interpretation of PK/PD analyses, PK/immunogenicity/biomarker measurement strategies etc.)
Plan and oversee study level activities including protocol authoring, clinical phase oversight, and reporting
Responsible (with clinicians and statisticians) for ensuring appropriate dose-range finding strategies which ultimately will lead to optimal doses and dosage regimens in patients
Accountable for ensuring appropriate design and implementation of End-to-End MIDD plan that conforms with best practices
Responsible for ensuring use of innovative analytical methods to integrate knowledge of PK, PD, patient characteristics and disease states to optimize doses, dosage regimens and study designs
Provide End-to-End clinical pharmacology contribution to regulatory documents (e.g., Briefing documents, Regulatory queries, Investigator’s Brochures, IND, NDA/MAA, etc.)
Develop new methodologies through internal and/or external collaborations with world leading experts
Coach less experienced colleagues and team members
Stay abreast of literature, regulatory guidelines, and internal guidance and SOPs
Influence external environment through publications, presentations, and representation at scientific societies and industrial consortium

Requirements

What you’ll need

Pharm. D., M.D./Ph.D., or equivalent training/experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or related discipline
1+ years of industry experience in clinical pharmacology and/or clinical PK/PD and/or Pharmacometrics/Systems Pharmacology
Intimate knowledge of drug development and experience in applying quantitative pharmacology approaches to knowledge integration
Strong quantitative skills and expertise (e.g. experience in mechanistic PK/PD modeling/systems pharmacology, literature meta-analyses, population modeling, and clinical trial simulations using NONMEM, R, etc.)
Excellent written and verbal communication skills
Demonstrated presentation skills
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Benefits

Comp & perks

401(k) plan with Pfizer Matching Contributions
Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits including medical, prescription drug, dental and vision coverage

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

clinical pharmacologypharmacokineticspharmacometricsmechanistic PK/PD modelingpopulation modelingclinical trial simulationsdose-range finding strategiesanalytical methodsbiomarker measurement strategiesquantitative pharmacology

Soft Skills

leadershipcommunicationcoachingcollaborationinfluencepresentation skillsoversightguidanceteamworkproblem-solving

Certifications

Pharm. D.M.D.Ph.D.