Oxford BioTherapeutics

Scientist

• Design, execute, and lead in vitro functional studies supporting target discovery, validation, lead selection and optimization, and preclinical development of T-cell engagers.
• Develop, optimize, and run T-cell functional assays to inform potency, selectivity, and safety, including cytotoxicity, cytokine release, activation, immune profiling, and reporter assays.
• Design and run co-culture assays evaluating T-cell-mediated tumor cell killing in response to T-cell engagers.
• Design and execute primary human T-cell assays, including activation, cytokine release, T-cell exhaustion, mixed lymphocyte reaction assays, and proliferation.
• Generate and interpret complex datasets with emphasis on scientific rigor, reproducibility, and data quality.
• Build decision-focused data packages and communicate scientific conclusions and recommendations to project teams, management, and external collaborators.
• Develop and execute multiparameter flow cytometry, including activation and intracellular cytokine staining.
• Design and perform real-time cytotoxicity assays, including IncuCyte and eSight, and other functional readouts relevant to T-cell engager activity.
• Characterize T-cell engagers using cell-based functional assays, including cytokine release and cytotoxicity.
• Understand TCE formats and improve tumor-specific killing efficacy.
• Collaborate across teams to evaluate and optimize T-cell engager molecules.
• Coordinate with external collaborators and CROs to deliver high-quality, timely data.
• Identify project risks, propose mitigation strategies, and communicate progress and challenges to stakeholders.
• Monitor scientific literature and competitive landscapes relevant to T-cell engagers, immune-redirecting modalities, and OGAP-selected targets.
• Propose innovative experimental approaches to accelerate early-stage discovery.
• Serve as an internal subject matter expert in T-cell immunobiology and immune-redirecting therapies.
• Foster scientific rigor, learning, transparency, accountability, and inclusion.
• Act as a scientific thought leader within the research organization.
• Adhere to OBT’s Quality Management System, including SOPs, documentation standards, electronic lab notebooks, and required training.
• Support audit readiness and continuous improvement of laboratory systems and workflows.

T-Cell Biologist – Scientist/Sr. Scientist