T-Cell Biologist – Scientist/Sr. Scientist

Oxford BioTherapeutics

T-Cell Biologist advancing T-cell engagers and antibody therapeutics for cancer at Oxford Biotherapeutics. Designing functional immunology assays and translating complex data into discovery and preclinical decisions.

Posted 8/5/2026full-timeSan Jose • California • 🇺🇸 United StatesSenior💰 $140,000 - $160,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates deep expertise in T-cell immunobiology and hands-on experience with T-cell engagers, including the design and execution of complex functional assays. Proficient in data analysis and communication of scientific findings to diverse audiences, while fostering collaboration and scientific rigor.

Highest-signal resume keywords

T-Cell Immunobiology ExpertiseMultiparameter Flow CytometryCell-Based Functional AssaysData Analysis and InterpretationStrong Communication Skills

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

T-Cell Engager DevelopmentCytotoxicity AssaysCytokine Release AssaysPrimary Human T-Cell IsolationIntracellular Cytokine StainingCo-Culture AssaysMixed Lymphocyte Reaction AssaysReporter AssaysData Quality AssuranceExperimental Design

Soft Skills

Team-Oriented MindsetIndependent Viewpoint FormationScientific Thought LeadershipAccountabilityTransparency

Tools & Technologies

IncuCyteESightAlphaLISALuminexElectronic Lab Notebooks

Industry Keywords

Biologics DiscoveryPreclinical DevelopmentImmunologyCell BiologyQuality Management System

About the role

Key responsibilities & impact

Design, execute, and lead in vitro functional studies supporting target discovery, validation, lead selection and optimization, and preclinical development of T-cell engagers.
Develop, optimize, and run T-cell functional assays to inform potency, selectivity, and safety, including cytotoxicity, cytokine release, activation, immune profiling, and reporter assays.
Design and run co-culture assays evaluating T-cell-mediated tumor cell killing in response to T-cell engagers.
Design and execute primary human T-cell assays, including activation, cytokine release, T-cell exhaustion, mixed lymphocyte reaction assays, and proliferation.
Generate and interpret complex datasets with emphasis on scientific rigor, reproducibility, and data quality.
Build decision-focused data packages and communicate scientific conclusions and recommendations to project teams, management, and external collaborators.
Develop and execute multiparameter flow cytometry, including activation and intracellular cytokine staining.
Design and perform real-time cytotoxicity assays, including IncuCyte and eSight, and other functional readouts relevant to T-cell engager activity.
Characterize T-cell engagers using cell-based functional assays, including cytokine release and cytotoxicity.
Understand TCE formats and improve tumor-specific killing efficacy.
Collaborate across teams to evaluate and optimize T-cell engager molecules.
Coordinate with external collaborators and CROs to deliver high-quality, timely data.
Identify project risks, propose mitigation strategies, and communicate progress and challenges to stakeholders.
Monitor scientific literature and competitive landscapes relevant to T-cell engagers, immune-redirecting modalities, and OGAP-selected targets.
Propose innovative experimental approaches to accelerate early-stage discovery.
Serve as an internal subject matter expert in T-cell immunobiology and immune-redirecting therapies.
Foster scientific rigor, learning, transparency, accountability, and inclusion.
Act as a scientific thought leader within the research organization.
Adhere to OBT’s Quality Management System, including SOPs, documentation standards, electronic lab notebooks, and required training.
Support audit readiness and continuous improvement of laboratory systems and workflows.

Requirements

What you’ll need

Deep expertise in T-cell immunobiology, with hands-on experience working with T-cell engagers and/or bispecific antibody formats.
Strong hands-on experience with PBMC and primary human T-cell isolation, culture, and functional assays.
Experience with multiparameter flow cytometry and panel design.
Experience with intracellular cytokine staining and other flow-based assays.
Experience with cell-based reporter assays.
Ability to design, analyze, and interpret complex datasets and translate results into clear scientific conclusions.
Strong written and verbal communication skills, with ability to present data to multidisciplinary audiences.
Humble, team-oriented mindset with ability to form and voice clear, independent viewpoints.
Scientist level: PhD with 1–3 years of relevant post-PhD experience, or MS with 5–7 years of relevant industry experience in immunology, cell biology, or biologics discovery.
Senior Scientist level: PhD with 4–6 years of relevant post-PhD experience, or MS with 8–12 years of relevant industry experience demonstrating increasing scientific independence and technical leadership.
Preferred: experience contributing to biologics discovery programs from early discovery through lead optimization and/or preclinical development.
Preferred: track record of scientific impact through publications, patents, presentations, or program advancement.
Preferred: experience with traditional and homogeneous ELISA-derived platforms, including AlphaLISA and/or multiplex systems such as Luminex.

Benefits

Comp & perks

Medical, dental and vision insurance for employee and dependents
FSA (Flexible Spending Account)
STD, LTD, Basic Life and AD&D Insurance, Supplemental Life
401(k) Plan
120 hours of Paid Time Off
5 sick days per year
11 holidays
Employee Referral Bonus Program
Annual bonus program
New hire stock options