Natera

VP, Chief Information Security Officer, CISO

Natera

full-time

Posted on:

Location Type: Remote

Location: CaliforniaUnited States

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Salary

💰 $257,600 - $322,000 per year

Job Level

About the role

  • Own and operate the end-to-end enterprise cybersecurity program, including strategy, architecture, operations, governance, and compliance.
  • Establish a multi-year security roadmap aligned with business priorities, technology evolution, and regulatory requirements.
  • Drive program maturity, ensuring continuous improvement across all domains of cybersecurity. Ensure security is integrated into enterprise planning, product development, and operational execution.
  • Develop and maintain a risk-based cybersecurity investment framework to prioritize initiatives and allocate resources effectively.
  • Lead architectural decisions across: identity and access systems, data protection and encryption strategies, network and zero-trust architectures, secure platform design for clinical and genomic systems and for agentic workflows.
  • Present regular updates to executive leadership on cyber risk posture, threat landscape, program maturity, incident readiness and response. Lead Board-level discussions on cybersecurity strategy, risk tolerance, and investment priorities.
  • Define and execute a strategy for AI-assisted cybersecurity operations, leveraging machine learning, automation, and advanced analytics to enhance detection and response capabilities.
  • Build a highly automated, intelligence-driven SecOps function that minimizes manual intervention and improves speed and accuracy of threat identification and remediation.
  • Drive adoption and optimization of modern security platforms, including: Next-generation SIEM/SOAR, CNAPP / CSPM, EDR/XDR, Identity intelligence platforms. Leverage AI/ML to improve signal-to-noise ratio in security alerts, detect anomalous behavior across security domains, and automate triage, investigation, and response workflows
  • Integrate AI capabilities into threat intelligence, vulnerability management, and risk analysis processes. Continuously evaluate emerging AI security tools and capabilities, balancing innovation, risk, and operational value.
  • Oversee enterprise security operations including monitoring, detection, and response. Lead incident response and crisis management, ensuring rapid containment and recovery.
  • Own compliance strategy across frameworks including SOC 2, ISO 27001, and NIST. Ensure alignment with healthcare and global data protection regulations (HIPAA, GDPR, CCPA).

Requirements

  • 20+ years of progressive cybersecurity leadership experience.
  • Bachelor’s degree in Computer Science, Cybersecurity, Engineering, or a related technical field required. Advanced degree (Master’s or PhD) is strongly preferred.
  • Proven experience owning and operating an enterprise-wide cybersecurity program, including strategy, execution, and governance. Strong track record of building modern, engineering-led security organizations in cloud-native environments.
  • Comfortable operating in high-growth, high-complexity environments. Experience building and scaling security programs in cloud-native, high-growth environments.
  • Deep, practical expertise across: Cloud security architecture (CSPM, CNAPP, workload security), Identity and access management (IAM, SSO, zero trust), Detection & response (SIEM, SOAR, EDR/XDR), Application and API security, Data security, encryption, and DLP, DevSecOps and secure SDLC practice
  • Strong balance of: technical depth (architecture, cloud, security engineering), and strategic leadership (program ownership, executive influence)
  • Hands-on experience implementing or operating AI-assisted security tools and automation frameworks.
  • Demonstrated success engaging with executive leadership and Boards on cybersecurity risk and investment decisions.
  • Experience developing risk-based investment strategies and prioritization frameworks. Ability to translate cybersecurity complexities into executive and Board-level communications.
  • Exceptional executive communication and storytelling skills.
  • Proven ability to influence senior leadership and drive alignment on complex risk and investment decisions.
Benefits
  • Annual performance incentive bonus
  • Long-term equity awards
  • Comprehensive health benefits (medical, dental, vision)
  • 401(k) with company match
  • Generous paid time off and company holidays
  • Additional wellness and work-life benefits
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
cybersecurity program managementcloud security architectureidentity and access managementdetection and responseapplication securitydata securityencryptionDevSecOpsAI-assisted security toolsrisk-based investment strategies
Soft Skills
executive communicationstorytellinginfluencestrategic leadershipprogram ownershipengagement with executive leadershipalignment on risk decisionscomplex problem solvingcontinuous improvementadaptability
Certifications
SOC 2ISO 27001NIST