Johnson & Johnson

Senior Principal Scientist, Translational Safety

Johnson & Johnson

full-time

Posted on:

Location Type: Hybrid

Location: San Diego • California • Massachusetts • United States

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Salary

💰 $137,000 - $235,750 per year

Job Level

Senior

About the role

  • Serve as a key member of the Translational Safety team in Translational PK/PD & Investigative Toxicology (TPPIT) and Preclinical Sciences & Translational Safety (PSTS).
  • Lead predictive toxicology initiatives in the early drug discovery and de-risking.
  • Work in matrixed teams evaluating, validating, recommending and integrating conventional in vitro models and complex cellular model systems for predicting off-target and major organ toxicities and guiding drug candidate selection during the early drug development process.
  • Communicate predictive investigative screening plans and updates to PSTS issues teams, project teams, and global leadership in partnership with leaders in Translational Safety and in Therapeutic Development.
  • Lead efforts to build and refine robust high-throughput in vitro organ specific cellular screening workflows.
  • Serve as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety Teams.
  • Evaluate external environment to identify new technologies, platforms & CROs with novel, cutting edge applications for in vitro toxicology.
  • Partner with members of Translation Safety & Discovery, Product Development and Supply (DPDS) functional groups to oversee the conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assays.
  • Function as a key member of Global Translational Safety Team partnering with global leads to establish strategic goals and objectives.
  • Maintain toxicology expertise through collaborations within TPPIT & PSTS globally, DPDS, and through organizational associations, literature reviews, continuing education, and publications.

Requirements

  • A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or related field is required.
  • A minimum of 2+ years postdoctoral training and 6+ years of relevant work experience is required.
  • Demonstrated knowledge in designing and conducting mechanistic in vitro studies incorporating high throughput applications of cell-based models required.
  • Experience with high throughput applications of organotypic models incorporating multiple cell types including immune cells required.
  • Demonstrated knowledge of drug discovery and experience with drug modalities beyond small molecules required.
  • Advanced knowledge of cellular and molecular toxicology and demonstrated experience driving projects to completion required.
  • Track record of working collaboratively to solve sophisticated scientific problems required.
  • Experience working on & leading highly matrixed, multi-disciplinary teams required.
  • Experience with AI/ML and in silico toxicology modeling preferred.
  • Board Certification in Toxicology preferred.
  • Must be highly motivated, curious, and organized individual with a team-oriented mentality who enjoys working in a fast-paced, dynamic environment, and working collaboratively across functions.
  • Excellent written, visual, and oral communication skills.
Benefits
  • medical
  • dental
  • vision
  • life insurance
  • short and long-term disability
  • business accident insurance
  • group legal insurance
  • consolidated retirement plan (pension)
  • savings plan (401(k))
  • annual performance bonus
  • Vacation –120 hours per calendar year
  • Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
  • Holiday pay, including Floating Holidays –13 days per calendar year
  • Work, Personal and Family Time - up to 40 hours per calendar year
  • Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
  • Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
  • Caregiver Leave – 80 hours in a 52-week rolling period10 days
  • Volunteer Leave – 32 hours per calendar year
  • Military Spouse Time-Off – 80 hours per calendar year
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
predictive toxicologyin vitro modelscellular model systemshigh-throughput screeningmechanistic cellular assaysorganotypic modelscell-based modelscellular toxicologymolecular toxicologydrug discovery
Soft Skills
collaborative problem solvingteam-oriented mentalitycommunication skillsorganizational skillsmotivationcuriosityleadershipmatrixed team experiencedynamic environment adaptabilityproject completion
Certifications
Ph.D.Board Certification in Toxicology