Ionis Pharmaceuticals, Inc.

Director

• Define and lead the end-to-end market insights strategy, determining critical business questions, setting the long-term research roadmap for assigned brands and pipeline programs and generating actionable recommendations
• Serve as the single point of contact and principal strategic advisor for the Tryngolza business, driving evidence-based decision-making for brand and portfolio strategy
• Identify and select external partners to support execution of market insights projects and manage the processes to achieve quality, cost-effective, and efficient delivery
• Leverage and synthesize information from multiple sources, including, but not limited to, qualitative and quantitative primary market research, data analysis, secondary research, field and competitive intelligence, etc.
• Pressure test conclusions and implications drawn from our market insight initiatives to ensure assessments are objective, data-driven, and relevant for the business
• Partner with the Forecasting team to develop and pressure test forecast assumptions and models
• Effectively translate and communicate outputs in the form of actionable insights and recommendations for the cross-functional teams and leadership as required for internal and external facing needs
• Reconcile dissenting views, negotiate with, and persuade others by applying high emotional intelligence to shift the thinking on sensitive / complex situations
• Coach and develop direct reports, including the completion of timely performance evaluations; as appropriate, hire, train, and mentor new employees to ensure successful onboarding
• Design and execute annual functional plan to accomplish critical business objectives, adapting and solving for evolving business needs, effectively managing team budget
• Lead ad hoc strategy projects and initiatives, as required (e.g., new indication / product / market evaluations)
• Cultivate and maintain formal networks with key external decision-makers and industry experts to ensure Ionis remains at the forefront of market trends and competitive dynamics

Director, Strategic Market Insights

• The Associate Director/ Director of Health Economics and Outcomes Research (Early Stage Pipeline) will be responsible for defining and executing early evidence generation strategies and deliverables across multiple programs.
• Support HEOR/COA endpoint strategy from Phase 1 to 3 clinical studies ensuring inclusion of patient-centric, clinically meaningful, and economically relevant outcomes.
• Contribute to commercial and global market access strategy to influence trial designs that meet expectations from multiple stakeholders.
• Lead development of HTA-grade cost-effectiveness and budget-impact models to support early decision-making, identify value drivers, pricing, value dossiers, and individual country-specific submissions.
• Build relationships with clinical and HEOR/HTA thought leaders and academic collaborators shaping input to specific projects and methodologies, particularly in rare disease; contribute to business development activities and support existing Ionis business partnerships.

Associate Director – Health Economics and Outcomes Research, Early Stage Pipeline

• Develop and lead U.S. market access strategies aligned with brand and portfolio objectives across a 3+ year horizon.
• Define value proposition and access roadmap from pre-launch through lifecycle management.
• Shape and implement integrated evidence plans, in partnership with HEOR and Medical Affairs to support access and payer negotiations.
• Serve as the enterprise subject matter expert on access, payer dynamics, and policy trends across the landscape and within specialty and rare disease.
• Oversee development of AMCP dossiers, payer communication tools (including Pre-approval Information Exchange and Payer Value Proposition) and field access tools (including product coverage, prior authorization criteria and patient support options).
• Guide economic modeling and budget impact analyses to support payer discussions.
• Collaborate and partner closely with Commercial to align access strategy with brand strategy.
• Engage with Government Affairs on policy implications and advocacy priorities.
• Represent the organization in external advisory boards and industry forums.
• Monitor payer landscape, competitive dynamics, and regulatory changes to inform strategy.
• Lead, coach, and develop high-performing Market Access professionals.
• Select and retain agency partners, holding full budget authority for access strategies.
• Drive cross-functional alignment in matrixed environments.

Director, US Value & Access

Medical Director

• Identify and forge professional peer-to-peer relationships with National, Regional, and Local key opinion leaders.
• Align and execute field activities in support of Medical Affairs Strategic plan.
• Identify and communicate research gaps, opportunities, and relevant field intelligence to inform medical strategy.
• Accelerate recruitment efforts and enhance subject retention at targeted clinical trial sites.
• Leverage expertise to enhance and broaden knowledge among field medical team colleagues.
• Attend medical/scientific meetings to represent Medical Affairs with KOLs and other HCPs, strengthen individual expertise as well as capture, integrate, and summarize information of strategic interest.
• Appropriately facilitate submission of Medical Education grants and Investigator-Initiated Research Support cross-functional colleagues (e.g., commercial, clinical operations, clinical development) in appropriate activities.
• Actively participate in relevant team meetings, organizational activities, and HQ-driven medical affairs and clinical research activities (e.g., advisory boards, publication planning, investigator meetings)
• Leveraging unique skill sets, assume lead responsibility for project work identified by Medical Affairs leadership and/or organizational priorities.

CardioMetabolic Field Medical Director, Great Lakes Region

Compliance

• Develop and maintain the annual risk-based monitoring plan, including collaboration with third-party consultants to support execution and continuous program improvement
• Lead and execute live (in-person and virtual) and transactional/desktop monitoring in partnership with other compliance team members and third-party consultants
• Define, track, and report key performance indicators (KPIs) and key risk indicators (KRIs) to assess compliance risk trends and monitoring program effectiveness
• Analyze monitoring data to identify trends, outliers, and emerging risk signals that inform monitoring priorities
• Oversee remediation and corrective action plans, including tracking progress and ensuring timely and effective resolution of monitoring findings
• Develop and maintain monitoring dashboards and reports (e.g., Excel, Tableau, Power BI, monitoring system)
• Translate analytics and monitoring results into clear, executive-ready insights
• Support monitoring system implementation and ongoing enhancement efforts
• Partner cross-functionally with Commercial, Medical, Finance, IT, HR, and other stakeholders to align compliance activities
• Provide compliance operational guidance and support for additional compliance initiatives, as needed

Assistant Director, Compliance Operations, Monitoring Lead

Manager

• Interact within assigned accounts to support patient access, providing proactive face-to-face (or virtual if appropriate) education on programs to providers and staff to support integration of those programs into office processes and workflows.
• Leverage data and analytical tools to address customer questions for issues related to payer policies and access requirements.
• Work with key members of customer accounts (e.g., providers, administrators, billing and coding staff, etc.) to appropriately support patient access.
• Address customer questions related to payer policies (e.g., utilization management, denial, and appeals) and patient reimbursement.
• Collaborate with aligned cross-functional partners (identified above) to share insights on customer needs and barriers related to access and reimbursement.
• Maintain a deep understanding of Ionis policies and requirements and perform all responsibilities with integrity and in a manner consistent with company guidance and prescribed Values and Behaviors.
• Handle Patient Identifiable Information (PII) appropriately (understand and ensure compliance with HIPAA and other privacy laws and regulations and internal Company compliance policies/guidelines).
• Responsible for identifying and reporting adverse events via the established Ionis systems as per applicable processes.

Field Access Manager

• Own the development and execution of integrated U.S. payer strategies across the Ionis commercial portfolio.
• Establish long-range access vision, coverage objectives, and reimbursement strategies aligned with brand and corporate priorities.
• Shape and implement enterprise-level access frameworks that can scale across current and future launches.
• Identify, quantify, and proactively mitigate access risks and reimbursement barriers.
• Provide forward-looking analysis of payer landscape shifts, policy changes, and competitive access dynamics.
• Lead U.S. access readiness strategy from pre-launch planning through lifecycle optimization.
• Oversee development of payer-facing and field access materials.
• Ensure alignment of clinical and economic evidence generation with payer requirements in partnership with HEOR and Medical Affairs.
• Influence economic modeling, value frameworks, and budget impact strategies to support coverage negotiations.
• Oversee pull-through strategies to accelerate coverage adoption and minimize patient access friction.
• Lead and develop a high-performing U.S. Value & Access organization and drive team execution to achieve measurable access outcomes.
• Establish clear strategic priorities and ensure alignment of resources against enterprise objectives.
• Build scalable capabilities to support portfolio expansion and future product launches.
• Foster a culture of collaboration, accountability, and continuous improvement.
• Partner closely with Brand, Medical Affairs, HEOR, Regulatory, Government Affairs, Pricing, Field Access, and Sales leadership to ensure cohesive execution.
• Integrate payer insights into brand planning, evidence strategies, and lifecycle investment decisions.
• Provide executive-level recommendations to senior leadership on reimbursement strategy and payer engagement.

Executive Director, Value & Access

• The Associate Director/ Director of Health Economics and Outcomes Research (Early Stage Pipeline) will be responsible for defining and executing early evidence generation strategies and deliverables across multiple programs.
• Support HEOR/COA endpoint strategy from Phase 1 to 3 clinical studies ensuring inclusion of patient-centric, clinically meaningful, and economically relevant outcomes.
• Contribute to commercial and global market access strategy to influence trial designs that meet expectations from multiple stakeholders.
• Lead development of HTA-grade cost-effectiveness and budget-impact models to support early decision-making, identify value drivers, pricing, value dossiers, and individual country-specific submissions.
• Contribute to global HEOR evidence-generation strategies by asset, aligning development programs with regulatory, HCP, and payer/HTA expectations.
• Build relationships with clinical and HEOR/HTA thought leaders and academic collaborators shaping input to specific projects and methodologies, particularly in rare disease.

Associate Director – Health Economics and Outcomes Research, HEOR, Early Stage Pipeline

• The Associate Director/ Director of Health Economics and Outcomes Research (Early Stage Pipeline) will be responsible for defining and executing early evidence generation strategies and deliverables across multiple programs.
• Support HEOR/COA endpoint strategy from Phase 1 to 3 clinical studies ensuring inclusion of patient-centric, clinically meaningful, and economically relevant outcomes.
• Contribute to commercial and global market access strategy to influence trial designs that meet expectations from multiple stakeholders.
• Lead development of HTA-grade cost-effectiveness and budget-impact models to support early decision-making, identify value drivers, pricing, value dossiers, and individual country-specific submissions.
• Partner with Global/US Market Access and Regulatory to ensure pivotal studies capture relevant endpoints.

Associate Director/Director, Health Economics and Outcomes Research – Early Stage Pipeline

Executive Director, US Value & Access

• Develop and lead U.S. market access strategies aligned with brand and portfolio objectives across a 3+ year horizon.
• Define value proposition and access roadmap from pre-launch through lifecycle management.
• Shape and implement integrated evidence plans, in partnership with HEOR and Medical Affairs to support access and payer negotiations
• Serve as the enterprise subject matter expert on access, payer dynamics, and policy trends across the landscape and within specialty and rare disease
• Oversee development of AMCP dossiers, payer communication tools (including Pre-approval Information Exchange and Payer Value Proposition) and field access tools (including product coverage, prior authorization criteria and patient support options).
• Guide economic modeling and budget impact analyses to support payer discussions
• Collaborate and partner closely with Commercial to align access strategy with brand strategy.
• Engage with Government Affairs on policy implications and advocacy priorities.
• Represent the organization in external advisory boards and industry forums.
• Monitor payer landscape, competitive dynamics, and regulatory changes to inform strategy.
• Lead, coach, and develop high-performing Market Access professionals.
• Select and retain agency partners, holding full budget authority for access strategies
• Drive cross-functional alignment in matrixed environments.

Director, Value & Access

• Develop and leverage relationships with business and clinical executives at PBMs/GPOs, National & Regional Commercial Plans.
• Responsible for the development and implementation of strategic business plans.
• Provides and presents the IONIS enterprise view of our pipeline with key decision makers at Commercial and Med D payers.

Director, National Accounts

• Assess strategic engagement and sales implications of short- and long-term actions with each payer customer and take action to move payer decisions in a direction that continue to open patient access to care with IONIS products.
• Provides and represents the IONIS enterprise view of our pipeline with key decision makers at VHA and DoD
• Collaborate with Patient Services and Chanel/Distribution to ensure reimbursement confidence and unimpeded access to all in-line brands to FDA label.
• Works closely with Value & Access, Marketing, Field Access Managers, Field Medical Directors, Government Affairs and Field Sales Leadership, to ensure consistent exchange of important payer information and messages that should be communicated.
• Provides periodic market updates to Sales Management that link important provider, payer and health care reform trends and issues as well as documents initiatives and their outcomes.