Director – Discovery PKPD Project Leader, Novel Modalities
Eli Lilly and Company
full-time
Posted on:
Location Type: Office
Location: Indianapolis • Massachusetts • United States
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Salary
💰 $177,000 - $259,600 per year
Job Level
About the role
- Serve as the Discovery PKPD project leader for genetic medicines programs, including ASOs, siRNA, LNP-mediated delivery, gene therapy (AAV and non-viral vectors), and antibody-siRNA conjugates (ARC)
- Develop and implement modeling strategies that enhance decision-making for genetic medicines inform translational research strategies
- Design, analyze, and interpret quantitative pharmacology and PK/PD studies
- Collaborate effectively with scientists within and outside the functional area to integrate PK/PD into team strategy and contribute to project team discussions, guiding key go/no-go decisions with quantitative approaches
- Communicate quantitative findings both internally and externally through scientific publications, conference presentations, and cross-functional forums
- Mentor junior scientists and contribute to the growth of PKPD modeling capabilities within the genetic medicines space and neuroscience space
Requirements
- PhD in Pharmacokinetics/Pharmacodynamics, Pharmacology, Pharmaceutical Sciences, Biomedical engineering, or a related subject area
- 5 or more years of relevant industry or CRO experience in translational and/or mechanistic PKPD modeling
- Experience with empirical or mechanistic PK/PD modeling to support drug discovery and/or development
- Experience with translational PK/PD modeling to support interspecies scaling, human dose projections, and first-in-human study design
- Experience with relevant modeling and simulation software such as NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim, or equivalent platforms
- Strong interpersonal communication skills, including demonstrated experience working effectively in a cross-functional, matrixed collaborative environment
Benefits
- eligibility to participate in a company-sponsored 401(k)
- pension
- vacation benefits
- eligibility for medical, dental, vision and prescription drug benefits
- flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
- life insurance and death benefits
- certain time off and leave of absence benefits
- well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
PKPD modelingquantitative pharmacologymechanistic modelingtranslational researchdrug discoveryhuman dose projectionsfirst-in-human study designempirical modelingdata analysisstatistical interpretation
Soft Skills
interpersonal communicationcollaborationmentoringteam strategy contributiondecision-makingcross-functional teamworkscientific communicationpresentation skillsleadershipguidance
Certifications
PhD in PharmacokineticsPhD in PharmacodynamicsPhD in PharmacologyPhD in Pharmaceutical SciencesPhD in Biomedical Engineering