Arvinas

Translator

• Conduct scientific and operational due diligence and selection of external biomarker CROs and assay platforms, leading vendor due diligence processes including, but not limited to assessment of biomarker technology, evaluations of biomarker assay feasibility, analytical performance and validation characteristics, and overall technical capability.
• Lead and oversee development, qualification, and validation of clinical biomarker assays (e.g., ELISA, Simoa, MSD, LC-MS/MS, Olink/SomaScan, NGS etc) in collaboration with internal teams and CROs, including review of assay analytical validation plans, biomarker reports, and technical documentation to ensure timely clinical biomarker assay deliverables and biomarker assay performance meets regulatory and industry standards for clinical use (e.g., GCLP, CLIA, CAP as applicable).
• Oversee external CROs/labs performing clinical biomarker testing, including vendor management. assay transfer and clinical sample testing. Ensure high-quality biomarker data generation, QC, and timely data transfer
• Cross-functional collaboration with Translational Sciences Lead, Clinical Operations, Biosample Operations, Data Management, and external vendors to ensure execution of biomarker readouts in our clinical studies.

Manager, Clinical Biomarker Assays – Translational Science, Neuroscience

Artificial Intelligence

• Explore state of the art tools for protein structure prediction and ternary complex modeling.
• Collect and prepare a comprehensive dataset of published ternary complex X-ray and cryo-EM structures.
• Rigorously evaluate the performance of different ternary complex modeling approaches.
• Prepare and present results at an internal Arvinas function at the conclusion of the internship.

Summer Intern – Computational Chemistry, Artificial Intelligence

Clinical Operations

• Assist with study documentation and maintenance of trial master files (TMF)
• Support coordination with study sites, CROs, and cross-functional teams
• Help track study timelines and key deliverables
• Perform basic data review and quality control checks for GCP compliance
• Participate in team meetings and support operational reporting
• Perform TMF filing, indexing, and quality control (QC) checks to ensure completeness and inspection readiness
• Track TMF metrics and follow up on missing or incomplete documents
• Support reconciliation activities (e.g., TMF vs. eTMF or vendor/CRO documents)
• Help ensure documents are filed in accordance with GCP and internal SOPs

Manager, Clinical Biomarker Assays – Translational Science, Neuroscience

Summer Intern – Computational Chemistry, Artificial Intelligence

Summer Intern – Clinical Operations