DMPK Scientist

Arvinas

DMPK Scientist at Arvinas advising on ADMET profiling and supporting clinical development assets. Contributing to drug discovery strategy and regulatory document preparation in a hybrid role.

Posted 6/29/2026full-timeNew Haven • Connecticut • 🇺🇸 United StatesSeniorLeadWebsite

About the role

Key responsibilities & impact

Serve as a project DMPK scientist and advise discovery teams on strategies for early ADMET profiling up to the selection of lead candidate into preclinical development.
Represent DMPK function on company-wide development teams to support the advancement of preclinical and clinical development assets.
Contribute to the in vitro DDI and other in vitro/in vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data as part of the IND enabling activities.
Recommend stage appropriate clinical DDI strategy to the clinical pharmacology function.
Contribute to outsource of DMPK studies and ensure timely and high quality conduct of in vitro and in vivo ADMET studies. Partner with key CROs to develop and customize ADMET assays to support PROTAC drug discovery and development.
Contribute to the preparation of DMPK component of regulatory documents such as IND, IB, or other documents.
Stay up to date with the scientific advance and regulatory landscape for DMPK science in drug discovery and development

Requirements

What you’ll need

In-depth knowledge or expertise on one or several aspects of DMPK science in drug discovery and/or development, such as biotransformation, bioanalysis, pharmacokinetics, toxicokinetics, DME- and transporter-based drug-drug interaction, PBPK or PK/PD modeling, human PK prediction.
General knowledge of drug discovery and development process.
Experience in representing DMPK function on discovery and development teams.
Ability to integrate DMPK knowledge of individual drugs and prepare DMPK components of regulatory documents.
Hands-on experience and proficiency in PK analysis with PK or modeling software such as Phoenix.
Knowledge of relevant regulatory guidance in areas such as drug-drug interaction, bioanalysis, and GLP.
Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship.
The duties of this role are generally conducted in a combination of lab and home office environments. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Benefits

Comp & perks

group medical, vision and dental coverage
group and supplemental life insurance
competitive package of base and incentive compensation

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

BiotransformationBioanalysisPharmacokineticsToxicokineticsDME-Based Drug-Drug InteractionPBPK ModelingPK/PD ModelingHuman PK PredictionPK AnalysisADMET Profiling

Soft Skills

Problem SolvingCollaborationCommunication