Senior Principal Scientist – Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead
Amgen
full-time
Posted on:
Location Type: Hybrid
Location: Thousand Oaks • California • United States
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Salary
💰 $183,958 - $204,835 per year
Job Level
About the role
- Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
- Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates
- Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates
- PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities
- Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications
- Mentor and cross-train PKDM-BA scientific colleagues
- Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept
Requirements
- Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience
- Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience
- Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience
- Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics
- Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable
- Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
- Expertise in antibody-siRNA bioanalytical approaches and considerations
- Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms
- Experience with respect to RT-qPCR and/or RT-ddPCR is also highly desirable
- Exceptional written and verbal communication skills
- Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
- group medical, dental and vision coverage
- life and disability insurance
- flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible.
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard skills
bioanalytical platformsADME assayspharmacokineticspharmacodynamic relationshipstoxicokineticsligand binding assaysimmunoassayhybridization assaysLC/MSRT-qPCR
Soft skills
mentoringcross-trainingcollaborationcommunication
Certifications
Doctorate degreeMaster’s degreeBachelor’s degree