4D Molecular Therapeutics

Medical Director

• Report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development
• Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
• Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
• Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
• Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
• Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
• Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
• Lead development and implementation of biomarker strategies for GA and broader retina programs
• Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
• Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
• Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
• Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
• Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
• Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.
• Works with the research organization and the portfolio management team to identify and support new project opportunities.
• Collaborates to identify program risks, and to create and implement mitigation strategies
• Other duties as assigned

Executive Medical Director, Retina Program

• Implement, execute, and oversee clinical trials within a clinical program
• Partner with Director of Clinical Operations to develop and manage clinical programs
• Provide operational leadership for trial planning, execution, and data collection
• Oversee day-to-day activities of Clinical Trial Operations and Clinical Data Management groups
• Collaborate on annual budget planning and vendor management
• Ensure clinical trials are inspection ready
• Coordinate development and review of protocols/amendments and operational execution

Associate Director, Clinical Operations – Retina Program

Clinical Research

• Support the Company's clinical trial activities
• Manage the day to day operations of one or more phase 1-3 clinical trials
• Serve as the primary unmasked contact for managing protocol execution
• Support establishment of study milestones and ensure accurate tracking of study metrics
• Ensure clinical trials are managed in accordance with ICH GCP, regulations, and protocols
• Conduct training of CRO study staff, monitors, investigational sites, and service providers

Clinical Trial Manager

• Lead clinical strategy and execution for ophthalmology trials, including protocol development, study oversight, and data interpretation.
• Serve as medical monitor for clinical studies, ensuring patient safety and data integrity.
• Author and review clinical documents including protocols, IBs, ICFs, INDs, CSRs, and regulatory submissions.
• Collaborate with cross-functional teams (clinical operations, regulatory, biometrics, safety, CMC, commercial) to drive program success.
• Engage with external experts, organize advisory boards, and contribute to scientific and medical communications.
• Identify and mitigate clinical and programmatic risks.
• Support portfolio development and evaluation of new clinical opportunities.
• Represent the company in regulatory and scientific forums as needed.

Director

• Develop and refine intellectual property strategy for 4DMT products and platforms; present IP strategy updates to executive leadership, as needed.
• Responsible for implementing key elements of 4DMT’s intellectual property strategy, and managing its patent, trade secret, and trademark portfolio; implements a strategy for IP lifecycle management.
• Directs outside counsel in the preparation and prosecution of applications and responding to office actions; directs outside counsel in evaluating the patentability of invention submissions and registrability of trademarks globally; manages related outside counsel budgets.
• Identifies strategic areas for patenting, trade secret protection, and trademarking; collaborates with R&amp;D, CMC, Clinical Science, and other functions to proactively identify and develop patentable intellectual property to prepare, file, and prosecute.
• Manages patentability, freedom-to-operate, infringement, validity, and regulatory exclusivity analyses.
• Supports and manage IP disputes and administrative proceedings, including oppositions and post-grant challenges.
• Identifies and tracks 4DMT trade secrets and provides counsel with respect to 4DMT’s trade secret protection practices.
• Provides IP perspective and counseling at 4DMT meetings and presents on IP topics.
• Counsels and trains internal clients on intellectual property practices and policies.
• Conducts IP due diligence for business development activities and supports IP due diligence related to financing activities.
• Drafts, reviews, and negotiates agreements to support R&amp;D and CMC activities, including NDAs, MTAs, MSAs, sponsored research agreements, consulting agreements, and licenses.
• Collaborates with Legal colleagues, Business Development, and other key leaders and functions on key strategic agreements, including licenses, collaboration agreements, and other business development efforts.
• Assists with other Legal Department matters, including litigation support, SEC reporting (IP-related sections), records management, compliance activities, and template projects.
• Other duties as assigned; nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Executive Director, IP

Clinical Operations

• Provide strategic and operational leadership for global clinical trial execution across the 4DMT lung portfolio.
• Responsible for delivering clinical programs aligned with corporate timelines, budget, quality, and regulatory expectations.
• Lead internal Clinical Operations teams and external partners/CROs.
• Collaborate with external teams to ensure efficient, high-quality, inspection-ready execution of Phase 1–3 clinical studies.
• Serve as a key cross-functional leader and Clinical Operations subject matter expert.

Executive Medical Director, Retina Program

Associate Director, Clinical Operations – Retina Program

Clinical Trial Manager

Medical Director

Executive Director, IP

Director, Clinical Operations – Lung Program