Executive Medical Director, Retina Program

4D Molecular Therapeutics

Executive Medical Director overseeing clinical trials in the ophthalmology therapeutic area at 4D Molecular Therapeutics. Leading biomarker strategies and ensuring regulatory compliance for retinal programs.

Posted 7/14/2026full-timeRemote • 🇺🇸 United StatesLead💰 $350,000 - $398,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive expertise in clinical trial leadership, particularly in Phase 1 retina studies, with a strong focus on study design, protocol development, and regulatory compliance. Proven ability to collaborate across multidisciplinary teams and effectively communicate complex clinical data and strategies.

Highest-signal resume keywords

Medical Degree (M.D.)Clinical Trial LeadershipPhase 1 Retina Clinical TrialsData Analysis and InterpretationICH-GCP and FDA Regulatory Knowledge

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Applicant Tracking System Keywords

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Hard Skills

Study DesignProtocol DevelopmentDose Escalation StrategySafety OversightMedical MonitoringBiomarker Strategy DevelopmentNDA/BLA/MAA Submission PlanningGene Therapy Clinical StudiesData InterpretationMedical Writing

Soft Skills

Effective CommunicationPublic Speaking

Certifications & Qualifications

Board CertificationRetina Fellowship Training

Industry Keywords

Clinical Ophthalmology ResearchBiopharmaceutical IndustryRegulatory ComplianceInternational Regulatory GuidelinesCross-Functional Team Leadership

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development
Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
Lead development and implementation of biomarker strategies for GA and broader retina programs
Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.
Works with the research organization and the portfolio management team to identify and support new project opportunities.
Collaborates to identify program risks, and to create and implement mitigation strategies
Other duties as assigned

Requirements

What you’ll need

Medical Degree (M.D.), other degrees considered with relevant experience
Residency training in Ophthalmology with a preference for subspecialty training in retina
Board certification/retina fellowship training are a plus
10+ years of clinical ophthalmology research in the biopharmaceutical industry
Experience with medical monitoring and oversight of Phase 1 retina clinical trials
Experience with gene therapy clinical studies
Experience in other phases (Phase 2, 3) of clinical research.
Experience with NDA/BLA/MAA submission planning and execution
Experience in data analysis, data interpretation, and medical writing
Knowledge of ICH-GCP and FDA regulatory guidelines.
Knowledge of international regulatory guidelines
Effective written and verbal communication skills, including public speaking.

Benefits

Comp & perks

Equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.