Weekday (YC W21)

Translational Biology Expert

Weekday (YC W21)

contract

Posted on:

Location Type: Remote

Location: United States

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Salary

💰 $110 - $135 per hour

About the role

  • Design and execute in vivo and in vitro studies linking molecular mechanisms to disease-relevant outcomes.
  • Select appropriate preclinical models with strong rationale for human translatability.
  • Develop biomarker strategies spanning target engagement to clinical response.
  • Evaluate formulation and delivery strategies for optimal tissue targeting.
  • Troubleshoot inconclusive or negative results and recommend next steps.
  • Build exposure-response relationships to inform clinical predictions.
  • Assess whether preclinical evidence supports target engagement and therapeutic activity.
  • Refine mechanistic hypotheses and design follow-up experiments.
  • Evaluate early safety signals and investigate biological drivers.
  • Assess immunogenicity risks and downstream implications.
  • Support portfolio decisions such as advancement, pivot, or termination based on data quality and risk.
  • Define safe and pharmacologically relevant starting doses for first-in-human studies.
  • Design dose escalation strategies informed by pharmacodynamics and safety margins.
  • Determine appropriate study power based on variability and expected outcomes.
  • Define patient selection and biomarker-driven enrichment strategies.
  • Select meaningful endpoints, balancing surrogate and clinical measures.
  • Plan interim analyses, safety monitoring, and adaptive trial designs.
  • Conduct exposure-response analysis and dose optimization.
  • Develop population PK/PD models and assess covariate impacts.
  • Support dose decisions using real-time trial data.
  • Perform longitudinal modeling of treatment response and efficacy trends.
  • Design statistical analysis plans across varied endpoint types (binary, continuous, time-to-event).
  • Implement multiplicity adjustments and sample size calculations.
  • Conduct subgroup and heterogeneous treatment effect analyses.
  • Address estimand considerations, missing data, and dropout handling.
  • Design adaptive trials with interim monitoring, futility criteria, and alpha control.

Requirements

  • PhD, MD, or PharmD in Pharmacology, Pharmaceutical Sciences, Biostatistics, Quantitative Biology, or related fields.
  • 5+ years of industry experience in pharma, biotech, or CRO environments.
  • Direct experience supporting programs from late preclinical stages through IND or early clinical development.
  • Strong ability to independently evaluate complex datasets and provide clear, actionable recommendations.
  • Excellent communication skills for both technical and non-technical stakeholders.
  • Based in the United States or United Kingdom.
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
in vivo studiesin vitro studiesbiomarker strategiesdose escalation strategiespopulation PK/PD modelsstatistical analysis plansexposure-response analysislongitudinal modelingadaptive trial designssafety monitoring
Soft Skills
independent evaluationactionable recommendationscommunication skills
Certifications
PhDMDPharmD