Senior Downstream Process Engineer, Commercial

Thermo Fisher Scientific

Senior Downstream Process Engineer leading the design and development of bioprocess solutions for capital projects at Thermo Fisher Scientific. Collaborating with global teams and industry leaders for drug substance manufacturing.

Posted 6/27/2026full-timeRemote • California, Massachusetts, Montana, New York, Pennsylvania • 🇺🇸 United StatesSenior💰 $120,000 - $210,000 per yearWebsite

About the role

Key responsibilities & impact

Lead downstream process design, including PFDs, P&IDs, balances, and equipment specs
Develop scalable solutions for harvest, clarification, depth filtration, TFF, and chromatography purification systems
Ensure compliance with cGMP and global regulatory standards
Lead FEL/FEED efforts, translating customer needs into defined scopes
Develop costed proposals with scope, assumptions, risks, and exclusions
Support CAPEX estimates aligned with commercial and margin goals
Serve as primary technical contact for customers and project teams
Lead design reviews, technical discussions, and executive presentations
Collaborate cross-functionally across sales, engineering, and global teams
Contribute to technical marketing (white papers, webinars, presentations)
Provide technical guidance during early project phases as needed

Requirements

What you’ll need

Bachelor’s degree in Chemical Engineering, Biochemical Engineering, or related technical field required; Master’s or PhD preferred
8+ years of experience in downstream process engineering, purification, or bioprocess system design within the biopharma or life sciences industry
Strong expertise in downstream processing, including harvest/clarification, depth filtration, tangential flow filtration (TFF), and chromatography
Experience with capital equipment projects and development of complex engineering proposals
Demonstrated experience in front-end engineering, process scale-up, and purification process design
Familiarity with single-use technologies and automation systems (PLC/SCADA, DeltaV) preferred
Strong understanding of cGMP and global regulatory requirements (FDA, EMA, ICH)
Proven ability to collaborate across cross-functional and global teams
Excellent communication and presentation skills, with experience engaging technical and executive stakeholders
Ability to manage multiple priorities in a fast-paced, customer-driven environment.

Benefits

Comp & perks

Health insurance
401(k)
Paid time off (at least 120 hours)
10 paid holidays annually
Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
Accident and life insurance
Short- and long-term disability
Employee assistance and family support programs
Commuter benefits
Tuition reimbursement
Employees’ Stock Purchase Plan (ESPP)

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

downstream process designpurification systemsharvestclarificationdepth filtrationtangential flow filtration (TFF)chromatographyprocess scale-upengineering proposalssingle-use technologies

Soft Skills

collaborationcommunicationpresentation skillstechnical guidanceproject managementcustomer engagementcross-functional teamworkleadershipproblem-solvingprioritization

Certifications

Bachelor’s degree in Chemical EngineeringBachelor’s degree in Biochemical EngineeringMaster’s degreePhD