Principal Software Engineer – AI-Native

RxSense

Principal Software Engineer building AI-driven systems for a healthcare technology company. Leading technical architecture in an AI-focused role with a strong emphasis on quality and performance.

Posted 7/10/2026full-timeRemote • 🇺🇸 United StatesLead💰 $210,000 - $275,000 per yearWebsite

Tech Stack

Tools & technologies

.NETPythonTypeScript

About the role

Key responsibilities & impact

Architect and build production systems across a multi language stack: C#/.NET services, Python AI and data pipelines, and occasional TypeScript
Set the example for an AI forward, high technical standard across the broader engineering organization, leading through craft rather than organization wide authority
Design and drive adoption of offline evaluation frameworks (test suites, golden datasets, regression harnesses wired into CI/CD) for LLM based and other non deterministic components
Build online evaluation and monitoring that continuously assesses live model and system behavior in production, including drift and regression detection
Partner with engineering leadership to surface systemic risks in AI features, such as reliability, correctness, and drift, and drive the fixes
Lead architecture reviews for major initiatives and mentor senior and staff engineers on system design, evaluation methodology, and AI forward practices
Prototype and ship new AI capabilities

Requirements

What you’ll need

8+ years of professional software engineering experience
Depth across backend and AI/ML systems, working in some combination of C#/.NET, Python, and TypeScript.
Experience with LLM observability, prompt and response evaluation, or agentic system testing
A track record of setting technical standards that other engineers and teams adopt.
Strong communication skills, with the ability to align engineers and leadership around a shared technical direction.
Comfort working in an AI forward engineering environment, for example with agentic coding tools such as Claude Code.
Bachelor's degree in Computer Science, Engineering, or a related field preferred. Equivalent practical experience will be considered in lieu of a formal degree.

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account RxSense Website LinkedIn All Job Openings 201 - 500 employees ⚕️ Healthcare Insurance 💊 Pharmaceuticals ☁️ SaaS 💰 Private Equity Round on 2020-05 Healthcare Insurance
Pharmaceuticals
SaaS RxSense is a HealthTech company dedicated to modernizing pharmacy benefit management. They develop cutting-edge products that optimize claims adjudication and analysis, aiming to lower costs and improve access within the pharmacy ecosystem. RxSense offers solutions for PBMs, pharmacies, pharma manufacturers, payers, and consumers, supporting better outcomes for millions of people daily. Their products include advanced tools like the RxIQ Enterprise adjudication engine, business intelligence analytics platform, and AI-based pricing optimization. They are known for their flagship prescription savings brand, SingleCare, which helps consumers secure affordable prices while benefiting pharmacy partners. Principal Software Engineer – AI-Native 🔥 2 minutes ago 🇺🇸 United States – Remote 💵 $210k - $275k / year ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor Python TypeScript .NET Apply Now Find Hiring Managers Customize resume + cover letter Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Architect and build production systems across a multi language stack: C#/.NET services, Python AI and data pipelines, and occasional TypeScript
Set the example for an AI forward, high technical standard across the broader engineering organization, leading through craft rather than organization wide authority
Design and drive adoption of offline evaluation frameworks (test suites, golden datasets, regression harnesses wired into CI/CD) for LLM based and other non deterministic components
Build online evaluation and monitoring that continuously assesses live model and system behavior in production, including drift and regression detection
Partner with engineering leadership to surface systemic risks in AI features, such as reliability, correctness, and drift, and drive the fixes
Lead architecture reviews for major initiatives and mentor senior and staff engineers on system design, evaluation methodology, and AI forward practices
Prototype and ship new AI capabilities 🎯 Requirements
8+ years of professional software engineering experience
Depth across backend and AI/ML systems, working in some combination of C#/.NET, Python, and TypeScript.
Experience with LLM observability, prompt and response evaluation, or agentic system testing
A track record of setting technical standards that other engineers and teams adopt.
Strong communication skills, with the ability to align engineers and leadership around a shared technical direction.
Comfort working in an AI forward engineering environment, for example with agentic coding tools such as Claude Code.
Bachelor's degree in Computer Science, Engineering, or a related field preferred. Equivalent practical experience will be considered in lieu of a formal degree. Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score Similar Jobs Staff Software Engineer – AI Marketing 🔥 12 minutes ago Luxury Presence 201 - 500 🏠 Real Estate Website LinkedIn All Job Openings Staff Software Engineer leading AI product initiatives at Luxury Presence. Collaborating with engineering teams to build next-generation software architecture and features for real estate professionals. 🇺🇸 United States – Remote 💵 $200k - $250k / year ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor AWS Cloud DynamoDB ElasticSearch GraphQL JavaScript Kafka Node.js Postgres React TypeScript Principal Machine Learning Engineer, Artificial Intelligence – AI 🔥 18 hours ago TTEC 10,000+ employees 🤝 B2B Website LinkedIn All Job Openings Principal Machine Learning Engineer responsible for architecting and building large-scale ML systems. Leading design and deployment processes effectively in a remote work environment. 🇺🇸 United States – Remote 💵 $170k - $200k / year 💰 Post-IPO Debt on 2021-11 ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor Apache PyTorch Ray Spark Staff Machine Learning Engineer, Artificial Intelligence, AI 🔥 18 hours ago TTEC 10,000+ employees 🤝 B2B Website LinkedIn All Job Openings Staff Machine Learning Engineer creating reliable, scalable ML systems from AI research and collaborating on infrastructure and product teams. 🇺🇸 United States – Remote 💵 $150k - $170k / year 💰 Post-IPO Debt on 2021-11 ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor Principal AI-Driven Enterprise Support Engineer 🕒 Yesterday NICE 5001 - 10000 ☁️ SaaS 🤖 Artificial Intelligence 📡 Telecommunications Website LinkedIn All Job Openings Principal AI-Driven Enterprise Support Engineer at NICE developing AI-augmented enterprise support strategies. Leading technical escalations and customer interactions with Fortune 500 clients. 🇺🇸 United States – Remote ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor Cloud AI Principal Engineer 🕒 Yesterday WEX 5001 - 10000 🚗 Transport 💸 Finance 💳 Fintech Website LinkedIn All Job Openings Principal AI/ML Engineer leading AI/ML engineering initiatives for a global commerce platform. Driving technology development while collaborating closely with cross-functional teams. 🇺🇸 United States – Remote 💵 $250.3k - $289k / year 💰 $310M Post-IPO Debt on 2020-06 ⏰ Full Time 🔴 Lead 🤖 AI Engineer 🦅 H1B Visa Sponsor AWS Azure Cloud Java Kubernetes Python Ray SDLC Spark Terraform View More AI Engineer Jobs 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Find jobs using your resume Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

Software EngineeringBackend DevelopmentAI/ML SystemsSystem DesignEvaluation MethodologyRegression TestingCI/CD IntegrationData Pipeline DevelopmentMonitoring and AssessmentPrototype Development

Soft Skills

Strong CommunicationMentoringCollaboration