Psivant Therapeutics

Research Scientist

• Advance peptide therapeutics, especially macrocyclic peptides, and small molecule programs from screening to development candidate selection
• Champion cross-functional collaboration with CADD, biophysics, structural biology, DMPK, and biology teams to design molecules, achieve program goals, and meet timelines
• Implement structure-based and computational drug design to optimize peptide and small molecule therapeutics; prioritize and implement synthesis
• Manage teams of external synthetic chemists to ensure timely delivery of complex target molecules for biological testing
• Interpret analytical results to ensure compound quality, data integrity, and project success
• Stay current with chemistry, medicinal chemistry, project-relevant literature, and new patent application filings
• Lead research teams or serve as medicinal chemistry lead from concept through lead optimization toward clinical development
• Collaborate across computational chemistry, biophysics, structural biology, and biology functions to provide actionable insights and strategic guidance

Principal Scientist, Medicinal Chemistry

Designer

• Design small molecule and related-modality therapeutics using structural, simulation, ML, and assay data
• Lead computational analysis and design activities on cross-functional drug discovery projects
• Apply computational tools and medicinal chemistry knowledge across target selection, druggability analysis, hit identification, hit-to-lead, lead optimization, and clinical candidate nomination
• Collaborate with the computational development team to align platform application development and R&D priorities
• Develop modifications and improvements to internal applications and physics-based simulation capabilities
• Assess the fidelity and accuracy of calculations
• Train and mentor team members on modeling and AI/ML concepts
• Analyze simulation and AI/ML results, derive actionable hypotheses, and communicate findings
• Report to the Senior Director of CADD and collaborate with experimental medicinal chemistry, structural biology, and application engineering teams

Principal Scientist, Medicinal Chemistry

Consultant Scientist, Computer Aided Drug Design