FREE ACCESS
5,000–10,000 jobs/day
See all jobs on JobTailor
Search thousands of fresh jobs every day.
Discover
- Fresh listings
- Fast filters
- No subscription required
Create a free account and start exploring right away.
Principal Biologist
ProximaBiologist designing and executing cell-based pharmacology assays for proximity drug discovery at Proxima. Collaborating with computational scientists and managing external partnerships in a fast-paced environment.
About the role
Key responsibilities & impact- Design and execute cell-based pharmacology assays to evaluate proximity-inducing compounds (degraders, molecular glues, stabilizers)
- Manage CRO relationships for outsourced assays and run high-priority experiments in-house
- Characterize compound activity profiles: dose-response, kinetics, selectivity, mechanism of action, and SAR at the cellular level
- Build and validate disease-relevant cellular models (engineered cell lines, primary cells, co-culture systems) for target validation and translational pharmacology
- Develop and optimize quantitative assay readouts including high-content imaging, flow cytometry, reporter systems, and multiplexed approaches
- Collaborate with computational scientists and the XLMS platform team, providing biological feedback to improve ML model predictions and data generation priorities
- Prepare data packages for internal decision-making, BD/partnership discussions, and due diligence
Requirements
What you’ll need- PhD in cell biology, pharmacology, molecular biology, or a related discipline
- 3–8 years of post-PhD experience in a biotech or pharma drug discovery environment, ideally in proximity biology, targeted protein degradation, or molecular glue programs
- Deep hands-on expertise in designing and executing cell-based pharmacology assays (degradation assays, ternary complex formation, ubiquitination, reporter systems)
- Experience with quantitative cellular techniques: high-content imaging, flow cytometry, AlphaLISA/HTRF, NanoBRET, Western blot, ELISA, and/or proteomics-based approaches (TMT, global proteomics)
- Track record of working at the interface of computational predictions and experimental validation
- Comfortable working in a fast-paced, resource-constrained environment where you own the experimental design end to end
- Strong scientific communication skills; able to present data clearly to computational and medicinal chemistry and biology audiences.
Benefits
Comp & perks- Health insurance
- Flexible work arrangements
- Professional development opportunities
ATS Keywords
✓ Tailor your resumeApplicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
Cell-Based AssaysQuantitative TechniquesDegradation AssaysTernary Complex FormationUbiquitinationReporter SystemsAlphaLISAHTRFNanoBRETProteomics
Soft Skills
Scientific CommunicationData Presentation