Proofpoint

VP, Global In Vitro – Scientific Operations

Proofpoint

full-time

Posted on:

Location Type: Remote

Location: Remote • Florida, Maryland, New Jersey, North Carolina, Pennsylvania • 🇺🇸 United States

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Job Level

Lead

About the role

  • Lead all global in vitro scientific operations across Crown’s sites.
  • Ensure consistent and high-quality execution of in vitro studies, maintaining strong scientific rigor, reproducibility, and translational relevance.
  • Drive operational efficiencies through standardized workflows, SOP harmonization, and continuous improvement initiatives.
  • Oversee end-to-end operational workflows, including study design support, resource planning, execution, QC, reporting, and on-time delivery.
  • Drive improvements in productivity, reproducibility, cycle time, and cross-site alignment.
  • Establish and track operational KPIs (quality, timeliness, resource utilization, client satisfaction).
  • Identify opportunities to expand and modernize in vitro capabilities.
  • Lead implementation of new technologies, automation, and translational assays supporting MoA, PK/PD linkage, and IND-enabling studies.
  • Partner with biomarker, in vivo, and translational science leaders to ensure integration across platforms.
  • Act as a senior scientific representative for key client meetings, supporting proposal development, study design, troubleshooting, and data interpretation.
  • Support BD strategy with strong scientific storytelling, customer retention insights, and expansion of strategic partnerships.
  • Guide teams in translating client program objectives into actionable in vitro study plans.
  • Ensure alignment between scientific operations, project management, quality, and commercial teams.
  • Support cross-site initiatives, including platform harmonization and global capability mapping.
  • Build a high-performance culture emphasizing scientific rigor, innovation, accountability, and client-centricity.
  • Provide strategic mentorship, succession planning, and competency development across assay platforms.
  • Oversee global in vitro budgets, headcount planning, capital equipment strategy, and site capacity allocations.
  • Support revenue planning, operational forecasting, and margin optimization.
  • Partner with finance and senior leadership to drive operational efficiency and scalability.

Requirements

  • Ph.D. in cancer biology, immunology, pharmacology, molecular/cell biology, or related discipline.
  • 10+ years of experience in oncology/immunology preclinical research with deep expertise in in vitro assay platforms.
  • 7+ years of leadership experience managing scientific teams, ideally across multiple global sites.
  • Demonstrated track record in CRO scientific operations, with strong understanding of client expectations and data delivery requirements.
  • Extensive experience designing, executing, and interpreting mechanistic in vitro assays, immune effector studies, co-culture systems, and imaging-based platforms.
  • Proven ability to manage operational workflows, introduce new capabilities, and ensure high-quality scientific output.
  • Excellent communication skills, with experience in client-facing scientific roles.
  • Experience leading multi-site or global scientific operations within a CRO or service-based company (preferred).
  • Expertise with advanced or emerging in vitro technologies (preferred).
Benefits
  • Health insurance
  • 401(k) matching
  • Flexible work hours
  • Paid time off
  • Professional development opportunities

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard skills
in vitro studiesmechanistic in vitro assaysimmune effector studiesco-culture systemsimaging-based platformsoperational workflowsSOP harmonizationKPI trackingtranslational assaysoncology research
Soft skills
leadershipcommunicationstrategic mentorshipclient-centricityinnovationaccountabilityteam managementscientific storytellingtroubleshootingcross-site collaboration
Certifications
Ph.D. in cancer biologyPh.D. in immunologyPh.D. in pharmacologyPh.D. in molecular biologyPh.D. in cell biology