Senior Clinical Research Associate II

Pfizer

Senior Clinical Research Associate monitoring Pfizer clinical trials across remote Canadian investigator sites. Ensuring patient safety, regulatory compliance, recruitment and study closeout.

Posted 8/24/2026full-timeRemote • 🇨🇦 CanadaSenior💰 CA$92,100 - CA$153,500 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates extensive knowledge of clinical trial methodologies, ICH/GCP, and FDA regulations, with a strong ability to manage investigator sites and ensure compliance throughout the clinical trial process. Proven experience in mentoring and training clinical research associates while effectively collaborating with cross-functional teams.

Highest-signal resume keywords

Clinical Trial MonitoringGood Clinical Practice (GCP)Oncology ExperienceRegulatory ComplianceSite Management

ATS Keywords

Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills

Clinical Trial MethodologiesData Acquisition and CleaningProtocol DesignAdverse Event MonitoringCAPA DevelopmentSite Close-Out ActivitiesInvestigational Product ManagementPatient Enrollment SupportRisk ManagementDatabase Lock Management

Soft Skills

Verbal CommunicationWritten CommunicationLeadershipMentorshipCollaboration

Industry Keywords

Clinical ResearchFDA RegulationsICH GuidelinesOncologyVaccinesInternal MedicineInfectious DiseasesGlobal Clinical TrialsSite Care PartnerClinical Development Processes

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Manage, monitor and close out assigned investigator sites for clinical trials
Ensure clinical trials comply with the Study Monitoring Plan, applicable laws, Good Clinical Practice (GCP) and Pfizer standards
Manage operational aspects from site initiation through database lock
Serve as the primary point of contact for assigned investigator sites
Collaborate with the study team, Site Care Partner, vendors and investigator sites
Coach and train site personnel on protocols, operational risks and clinical trial risks
Attend investigator meetings as required
Support patient enrollment and recruitment initiatives
Conduct onsite and remote/electronic monitoring during site initiation, routine monitoring and site closure
Monitor adverse events and serious adverse events and collaborate with the Drug Safety Unit
Submit required reports, Trial Master File documentation, site reports, follow-up letters, protocol deviations, recruitment updates, clinical supply information, study progress updates and metrics
Identify and resolve site issues and develop corrective and preventive actions
Resolve data queries and conduct site close-out activities
Oversee investigational product receipt, handling, accountability, storage and destruction
Support database release and perform unblinded monitor responsibilities when required
Drive quality event remediation and develop and review CAPAs for audit observations
Mentor and train Clinical Research Associates and Senior Clinical Research Associates I
Serve as a subject matter expert for CRA-related processes
Participate in or lead global, regional or local working groups and process improvement initiatives
Perform Site Care Partner duties for small projects or under guidance for larger projects
Conduct co-monitoring activities

Requirements

What you’ll need

Bachelor’s degree in life sciences or a professional degree in a life sciences field, such as nursing, pharmacy or medicine, or equivalent qualifications
Extensive knowledge of clinical trial methodologies, ICH/GCP, FDA regulations and local country regulations
Minimum of 5 years of relevant experience in clinical research site monitoring
Preferably 3 years of experience in Oncology
Preferred therapeutic experience in Oncology, Vaccines, Internal Medicine or Infectious Diseases
Experience with global clinical trials
Fluency in English and the native language(s) of the country in which the individual will work
Bilingualism in French and English; advanced spoken and written English required
Superior knowledge of clinical research and development processes
Knowledge of global and local regulatory requirements
Understanding of clinical research operations, including monitoring, data acquisition and cleaning, and reporting
Knowledge of diseases, technical areas, investigational products and development plans
Ability to support sponsor regulatory interactions and inspections
Knowledge of protocol design and feasibility assessment
Understanding of regional and country-specific culture and medical practice
Ability to work in a matrix team environment and influence, drive or lead initiatives through others
Ability to evaluate, interpret and present complex issues and data for risk management and mitigation
Superior verbal and written communication skills
Ability to motivate and align the monitoring community through leadership and mentorship
Significant travel (60–80%) within the cluster; international and weekend travel may be required
Valid passport and driver’s license

Benefits

Comp & perks

Commitment to diversity and inclusion
Equitable and accessible workplace
Accommodations available during the recruitment process
Candidate AI-use guidelines