Senior Director – Principal Technical Architect

Pfizer

Senior technical architect leading Pfizer’s secure, scalable digital platform strategy and engineering. Guiding AI-enabled delivery, architecture governance, reliability, and technical talent at global scale.

Posted 8/12/2026full-timeNew York City • California, New York, Pennsylvania, Washington • 🇺🇸 United StatesSenior💰 $214,900 - $358,100 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in technical strategy and architecture for digital platforms, with a focus on modern engineering practices, cloud technologies, and compliance in a global enterprise environment. Proven ability to lead high-performing teams, influence senior stakeholders, and drive measurable outcomes through effective collaboration and decision-making.

Highest-signal resume keywords

Technical Strategy OwnershipCloud Platform ExpertiseModern Engineering PracticesTeam Leadership and DevelopmentCompliance and Risk Management

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Technical ArchitectureIntegration PatternsAPIsAI-Enabled DeliveryAutomationData ManagementSecurityReliability EngineeringEnterprise PlatformsLarge-Scale Technology Delivery

Soft Skills

Influencing Senior LeadersBuilding Trusted PartnershipsClarity in Ambiguous SituationsFostering InclusionContinuous Learning

Industry Keywords

Digital PlatformsEnterprise ArchitectureGlobal Scale OperationsRegulated EnvironmentPrivacy Compliance

Tech Stack

Tools & technologies

Cloud

About the role

Key responsibilities & impact

Own the technical strategy for one of Pfizer’s key Digital Platforms, connecting business priorities, enterprise architecture standards, and emerging technology into a roadmap and target-state architecture
Serve as the Platform’s design authority, defining target architecture, technical standards, integration patterns, and major technical decisions
Lead and develop engineering teams that build and operate the Platform
Partner with senior business and Digital leaders, product owners, and divisional teams to translate needs into technical choices, delivery models, and measurable outcomes
Define responsible use of AI, automation, and modern engineering practices to improve speed, quality, decision-making, governance, and verification
Build a high-performing team and foster technical excellence, accountability, inclusion, and continuous learning
Establish expectations for reliability, security, documentation, observability, compliance, resilience, and operational excellence at global scale
Influence cross-team architecture decisions and guide technical outcomes across architecture, engineering, and platform operations

Requirements

What you’ll need

Bachelor’s degree in Computer Science, Engineering, Information Systems, or a related field
12+ years of significant senior engineering and technical leadership experience in enterprise platforms, cloud, or large-scale technology delivery
Experience owning technical strategy and architecture for a significant platform, product, or technology domain
Ability to lead and develop engineers, architects, and technical leads
Deep, hands-on expertise in modern engineering practices, cloud platforms, data and integration patterns, APIs, security, and reliability
Experience partnering with senior business and Digital stakeholders to shape technical direction, investment choices, and measurable outcomes
Experience in a highly regulated, global enterprise environment with complex compliance, privacy, security, and risk expectations preferred
Experience applying AI-enabled delivery, automation, and platform reuse preferred
Track record of influencing senior leaders, building trusted partnerships, and creating clarity in ambiguous, high-impact situations preferred
Recognized technical depth in the Platform’s core technology domain preferred
Candidates must be authorized to be employed in the U.S. by any employer
This position requires permanent work authorization in the United States
U.S. work visa sponsorship is not available now or in the future

Benefits

Comp & perks

Participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary
Eligibility to participate in Pfizer’s share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility