Staff Engineer, Senior Manager

Pfizer

Senior Staff Engineer driving robust HPC solutions and cloud infrastructure for drug discovery at Pfizer. Collaborating with teams to modernize scientific computing platforms and enhance performance.

Posted 7/28/2026full-timeNew York City • Connecticut, Massachusetts, New York • 🇺🇸 United StatesSenior💰 $124,400 - $207,400 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in designing and managing cloud infrastructure for HPC and ML/AI workloads, utilizing IaC tools like Terraform and CloudFormation. Proficient in containerization and orchestration technologies such as Docker and Kubernetes, with a strong focus on operational efficiency and performance optimization.

Highest-signal resume keywords

Cloud Infrastructure EngineeringInfrastructure As Code (IaC)HPC Deployment UtilitiesContainerization (Docker, Kubernetes)Monitoring and Logging (CloudWatch, Prometheus)

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Infrastructure ManagementCloud NetworkingAWSGCPTerraformCloudFormationSlurmDockerKubernetesNVIDIA GPU Computing

Tools & Technologies

AWS ParallelClusterAWS Parallel Computing ServicesGoogle Cloud Cluster ToolkitPrometheusGrafana

Industry Keywords

High-Performance Computing (HPC)Machine Learning (ML)Artificial Intelligence (AI)Distributed ComputingEnterprise Environment

Tech Stack

Tools & technologies

AWSCloudDockerGoogle Cloud PlatformGrafanaKubernetesPrometheusTerraform

About the role

Key responsibilities & impact

Design, implement, operate, and own robust and dependable infrastructure for HPC and ML/AI workloads in a cloud environment (AWS/GCP)
Lead containerization, deployment, and operation of user- and admin-facing HPC platforms (Slurm, Open On Demand, Prometheus/Grafana)
Translate stakeholder input into robust, high-performance, scalable, cost-effective computing platforms
Partner with HPC specialists to capture institutional knowledge and manual processes in IaC workflows
Develop and maintain infrastructure automation using IaC tools like Terraform and CloudFormation
Create reusable Terraform modules and enforce standards
Operationalize containerized solutions using Docker and Kubernetes
Own the full lifecycle of infrastructure management, from provisioning to operations, support, updating, and teardown of production computing platforms
Develop and maintain monitoring, logging, and alerting for the infrastructure (e.g., CloudWatch, Prometheus/Grafana)

Requirements

What you’ll need

B.S. in computer science, life science, data science or similar fields
6+ years of experience in cloud infrastructure engineering with a proven track record of developing and supporting robust IaC deployments
Experience managing scientific computing workloads in an enterprise environment
Advanced experience with at least one of AWS and GCP, including knowledge of core compute and storage services relevant to HPC
Solid understanding of cloud networking, identity, and security controls
Prior experience with HPC deployment utilities including AWS ParallelCluster, AWS Parallel Computing Services, and Google Cloud Cluster Toolkit (preferred)
Proficiency with distributed computing environments, especially EKS/GKE/Kubernetes (preferred)
Familiarity with HPC environments, job schedulers (Slurm), HPC application containers (Docker, Singularity, Apptainer) and NVIDIA GPU computing (preferred)

Benefits

Comp & perks

401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits including medical, prescription drug, dental and vision coverage