Senior Manager, Global Commercial Strategy – Early GI, Rheumatology, Neurology

Pfizer

Director of Early Commercial Rheumatology shaping disease-area strategies and commercial plans for Pfizer’s Inflammation & Immunology portfolio. Collaborating with cross-functional teams to optimize patient impact and enterprise value.

Posted 7/22/2026full-timeMassachusetts, New York • 🇺🇸 United StatesSenior💰 $124,400 - $207,400 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in commercial strategy development, portfolio management, and cross-functional collaboration within the pharmaceutical and biotechnology sectors, particularly in Rheumatology, GI, and Neurology. Proficient in synthesizing complex data to inform strategic decision-making and drive investment priorities.

Highest-signal resume keywords

Commercial Strategy DevelopmentPortfolio ManagementCross-Functional CollaborationMarket Access DynamicsAI-Enabled Tools Utilization

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Hard Skills

Commercial DevelopmentOpportunity AssessmentForecastingValuationBusiness Case DevelopmentStrategic PlanningAnalytical SkillsMarket ResearchLifecycle Value OptimizationEvidence Generation

Soft Skills

Strong CommunicationProblem-SolvingStakeholder ManagementExecutive PresenceInfluencing Without Authority

Tools & Technologies

AI ToolsDecision-Support Tools

Certifications & Qualifications

Bachelor's DegreeMBA or Advanced Degree Preferred

Industry Keywords

PharmaceuticalBiotechnologyLife SciencesRheumatologyGINeurologyI&ISpecialty CareCommercial StrategyPortfolio Strategy

About the role

Key responsibilities & impact

Support development of long-range commercial and portfolio strategy across a subset of Rheumatology, GI, and Neurology disease areas, spanning early pipeline assets, lifecycle opportunities, external innovation, and emerging disease-area opportunities.
Support generation of integrated near-, mid-, and long-term views of disease-area opportunities, risks, and investment priorities to inform portfolio decision-making.
Synthesize scientific, clinical, commercial, access, competitive, and patient insights to identify priority opportunities and strategic trade-offs.
Monitor shifts in the scientific and competitive landscape to identify emerging trends, market discontinuities, and implications for future I&I strategy.
Translate disease-area strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional portfolio discussions.
Provide commercial leadership for portfolio prioritization, investment choices, and development opportunities across assigned disease areas.
Pressure-test commercial assumptions, value drivers, risks, uncertainties, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance.
Lead development of executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, and recommended actions.
Partner with cross-functional leaders to align on key choices related to indication sequencing, evidence generation, market development, and lifecycle opportunities.
Support disciplined decision-making by ensuring assigned disease-area recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, and enterprise value.
Lead early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential future product concepts across assigned areas.
Develop and refine product concepts, target product profiles, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions.
Ensure unmet need, standard of care, competitive dynamics, patient/HCP insights, and access considerations are translated into differentiated commercial hypotheses.
Provide commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross-functional colleagues.
Build repeatable approaches for high-quality early commercial strategy outputs across the team.
Lead commercial strategy input for external innovation and Business Development opportunities relevant to assigned disease areas.
Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, and portfolio implications for potential external opportunities.
Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points.
Represent the commercial perspective in internal discussions related to external opportunities and broader disease-area strategy as needed.
Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the I&I portfolio.
Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, and Commercial Regions.
Foster a culture of enterprise thinking, scientific curiosity, accountability, collaboration, and talent development within the team.
Set expectations for responsible, AI-enabled ways of working across the team to improve speed, quality, consistency, and scalability of portfolio strategy outputs.
Champion use of AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, and decision-support efficiency.
Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, and strategic decision-support processes.
Use performance insights, stakeholder feedback, and team learnings to continuously improve AI-enabled ways of working across assigned disease areas.

Requirements

What you’ll need

Bachelor's degree required; MBA or advanced degree preferred.
6+ years with a BA/BS, 5+ years with MBA/MS, 1+ years with PhD or JD of experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, market research, forecasting, analytics, or related field.
Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations.
Experience leading early commercial assessment, business case development, opportunity assessment, or cross-functional strategic planning.
Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making.
Strong communication, executive presence, problem-solving, and stakeholder management skills.
Advanced degree in business, life sciences, public health, medicine, pharmacy, or related field preferred.
Experience in Rheumatology, GI, Neurology, I&I, specialty care, or other complex therapeutic areas preferred.
Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, forecasting, valuation, or investment prioritization.
Demonstrated ability to develop long-term strategies for products or disease areas and secure alignment from senior leadership.
Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization.
Track record of leading cross-functional teams, influencing without authority, and making recommendations with incomplete information.
Comfort working in an AI-native or AI-augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus.
Ability to thrive in ambiguity, operate with enterprise mindset, and adapt to evolving portfolio priorities.
Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.

Benefits

Comp & perks

Health benefits to include medical, prescription drug, dental and vision coverage.
401(k) plan with Pfizer Matching Contributions.
Additional Pfizer Retirement Savings Contribution.
Paid vacation, holiday and personal days.
Paid caregiver/parental and medical leave.
Participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary.
Eligibility to participate in our share based long term incentive program.
Comprehensive and generous benefits and programs to help our colleagues lead healthy lives.