Senior Director, Internal Medicine Portfolio Strategy Lead

Pfizer

Lead portfolio strategy for Internal Medicine and Antivirals at Pfizer. Responsible for long-range planning and commercial strategy development with cross-functional collaboration.

Posted 6/27/2026full-timeCambridge • Massachusetts, New York, Pennsylvania • 🇺🇸 United StatesSenior💰 $214,900 - $358,100 per yearWebsite

About the role

Key responsibilities & impact

Lead development of long-range commercial and portfolio strategy across the Internal Medicine and Antivirals portfolio
Establish integrated near-, mid-, and long-term views of portfolio opportunities, risks, and investment priorities to inform enterprise decision-making
Synthesize scientific, clinical, commercial, access, competitive, financial, and patient insights to identify priority opportunities and strategic trade-offs
Monitor shifts in the scientific, competitive, and market landscape to identify emerging trends, discontinuities, and implications for future Internal Medicine and Antivirals strategy
Translate portfolio strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional portfolio discussions
Provide senior commercial strategy leadership for portfolio prioritization, investment choices, and development opportunities across Internal Medicine and Antivirals priorities
Pressure-test commercial assumptions, value drivers, risks, uncertainties, resource implications, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance
Lead development of executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, scenarios, and recommended actions
Partner with cross-functional leaders to align on key choices related to portfolio sequencing, indication prioritization, evidence generation, market development, and lifecycle opportunities
Oversee early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential future product concepts across Internal Medicine and Antivirals
Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, portfolio implications, and prioritization considerations for potential external opportunities
Provide senior matrix leadership across cross-functional partners, helping align priorities, clarify decision points, and strengthen high-quality strategic outputs.

Requirements

What you’ll need

Applicant must have a bachelor's degree with at least 12 years of experience; OR a master's degree with at least 10 years of experience; OR a PhD with 7+ years of experience
Experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, forecasting, market research, analytics, or related field
Demonstrated experience leading complex cross-functional initiatives, influencing in matrixed environments, and shaping senior-level portfolio or investment decisions without direct authority
Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations
Experience leading portfolio strategy, early commercial assessment, business case development, opportunity assessment, investment prioritization, or cross-functional strategic planning
Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making
Strong communication, executive presence, problem-solving, and stakeholder management skills.

Benefits

Comp & perks

401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

portfolio strategycommercial developmentbusiness developmentforecastingmarket researchanalyticsinvestment prioritizationearly commercial assessmentbusiness case developmentcross-functional strategic planning

Soft Skills

strategic skillsanalytical skillscommunication skillsexecutive presenceproblem-solving skillsstakeholder managementinfluencing skillsleadershipsynthesis of informationmatrix leadership