Senior Director, Applied AI

Pfizer

Senior Director of Applied AI shaping enterprise-level AI strategy and architecture at Pfizer. Responsible for driving AI initiatives to create measurable business outcomes while leading a mixed team of engineers and vendors.

Posted 6/6/2026full-timeNew York City • New York • 🇺🇸 United StatesSenior💰 $214,900 - $358,100 per yearWebsite

About the role

Key responsibilities & impact

Shape and evolve enterprise or domain-level AI strategy, grounded in clear business value and transformation outcomes.
Connect AI initiatives explicitly to measurable impact, and influence leadership on where AI should be applied and how it should reshape processes and operating models.
Design and evolve enterprise AI operating models, the target technology landscape, and the relationships between platforms, capabilities, and embedded solutions.
Create decision frameworks and architectural principles that drive consistent decisions across teams.
Drive portfolio-level architectural decisions across initiatives, platforms, and reusable capabilities.
Define and steward 'what good looks like' across AI architecture, solution design, and operational execution.
Stay hands-on where it matters — architecture and code review with modern AI and agent frameworks.
Lead a mixed team of full-time engineers, contractors, and vendor partners across one or more initiatives.
Continuously assess emerging technologies, the vendor landscape, industry trends, and research.

Requirements

What you’ll need

12+ years in AI, data, or software architecture, with significant experience at enterprise or multi-domain scale.
Proven ability to shape enterprise or domain-level strategy and architecture direction, tied to measurable business outcomes.
Current hands-on technical proficiency — able to read, write, build, and review code with modern AI / agent frameworks.
Experience leading full-time engineers, contractors, and vendor partners to deliver production-grade systems.
Strong experience in operating-model design, governance frameworks, and architectural standardization.
Demonstrated ability to influence senior executive stakeholders.
Deep understanding across AI/ML and generative AI, system architecture, data architecture, and software engineering.
Excellent communication, translating complexity into clear business outcomes.

Benefits

Comp & perks

401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage
Eligibility to participate in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary
Eligibility to participate in our share based long term incentive program

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

AI architecturedata architecturesoftware architectureoperating-model designgovernance frameworksarchitectural standardizationAI frameworkscode reviewgenerative AIsoftware engineering

Soft Skills

leadershipinfluencecommunicationstrategic thinkingcollaborationdecision-makingproblem-solvingstakeholder managementteam managementtranslating complexity