Senior Staff Engineer, Software

PacBio

Senior Staff Software Engineer developing business-critical instrument control software for sequencing platforms at PacBio. Collaborating with cross-functional teams to drive high-impact software solutions.

Posted 5/15/2026full-timeSan Diego • California • 🇺🇸 United StatesSenior💰 $144,500 - $253,600 per yearWebsite

Tech Stack

Tools & technologies

Linux.NETPython

About the role

Key responsibilities & impact

Own and deliver business-critical instrument control software spanning multiple subsystems, directly impacting instrument performance, reliability, and customer experience
Drive technical design and implementation for complex, high-risk areas, independently defining approach and managing technical risk
Collaborate cross-functionally with mechanical, electrical, firmware, and systems teams to ensure robust hardware-software integration and clear requirements
Identify and resolve systemic issues in performance, reliability, and scalability, including proactively addressing technical debt
Lead design and code reviews while contributing hands-on development in C#/.NET, ensuring high-quality, maintainable software
Influence system architecture and technical direction, and mentor engineers to elevate team-wide engineering standards

Requirements

What you’ll need

Bachelor’s degree in Computer Science, Engineering, or a related discipline
10+ years of software engineering experience
Deep expertise in C#/.NET and proficiency in Python
Strong experience with real-time or embedded systems and hardware-software integration
Experience working with hardware systems such as robotics, optical systems, environmental sensors, or motion control
Strong proficiency with Linux environments
Solid understanding of software architecture, design principles, and best practices
Experience developing instrument control software, user interfaces, and system-level integrations
Experience designing and implementing APIs (e.g., RESTful services)
Demonstrated ability to independently drive complex technical projects from concept to production
Excellent interpersonal, written, and verbal communication skills.

Benefits

Comp & perks

Health insurance
Professional development opportunities
Flexible working arrangements

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

C#.NETPythonreal-time systemsembedded systemshardware-software integrationLinuxsoftware architectureAPI designinstrument control software

Soft Skills

interpersonal skillswritten communicationverbal communicationtechnical risk managementmentoringcollaborationproblem-solvingproject managementdesign reviewinfluence

Certifications

Bachelor’s degree in Computer ScienceBachelor’s degree in Engineering