Translational Biology Lead, Oncology Therapy Area

Orion

Translational Biology Lead advancing oncology programs within Orion Pharma. Responsible for biomarker discovery, assay development, and translational research with preclinical models.

Posted 7/10/2026full-timeCambridge • Massachusetts • 🇺🇸 United StatesSenior💰 $130,000 - $230,000 per yearWebsite

About the role

Key responsibilities & impact

Discover biomarkers for patient selection, target engagement, and pharmacodynamic (PD) effects
Drive design, development, validation, verification and implementation of translational and clinical-grade biomarker assays to inform essential clinical research questions
Ensure biomarker studies comply with GXP and other relevant regulatory standards. Partner with internal collaborators to identify and qualify CROs and other vendors appropriately.
Explore and apply innovative technologies (e.g., spatial omics, digital pathology) to advance biomarker development
Characterize targets (expression, stability, heterogeneity) to inform indication and patient selection strategies
Partnering with internal and external collaborators to develop and apply state-of-the-art in vitro, in vivo and ex-vivo models of oncology and Immuno-oncology to inform indication selection, patient selection, Mechanism of action, Mechanism of resistance and combination strategy
Lead study design, execution oversight, and rigorous analysis/interpretation of preclinical models to generate insights to support clinical development plan
Evaluate and implement innovative technologies and platforms that increase rigor, throughput, translational relevance, and decision quality from pre-clinical models

Requirements

What you’ll need

PhD in Cancer Biology, Biomedical Sciences, or related field
≥4 years experience in oncology biomarkers assay development and / or preclinical research within biotech/pharma or academic
MS in Biology, Pharmacology, or related field
≥8 years experience in oncology biomarkers assay development and / or preclinical research within biotech/pharma or academic
Broad subject matter expertise in key technical aspects of various biomarker assays (e.g. Flow cytometry, IHC.)
Strong expertise in diverse pre-clinical models (in vitro, ex vivo, in vivo) related to oncology and immune-oncology
Demonstrated experience in the appropriate application of various scientific technologies into translational insights

Benefits

Comp & perks

Continuous learning opportunities
Work on challenges that matter
Culture where every voice is heard

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

Biomarker DiscoveryAssay ValidationRegulatory ComplianceData AnalysisTarget Characterization

Soft Skills

CollaborationLeadershipCommunication