Global Asset Lead, Oncology Therapy Area

Orion

Global Asset Lead for oncology program accountability, ensuring successful delivery in research and development. Lead multi-functional teams, and drive strategic initiatives for the oncology asset.

Posted 4/27/2026full-timeCambridge • Massachusetts • 🇺🇸 United StatesSeniorWebsite

Tech Stack

Tools & technologies

About the role

Key responsibilities & impact

Lead the creation and annual update of the Integrated Development Plan, ensuring clinical, regulatory, technical, and commercial workstreams are harmonized into a single, cohesive roadmap.
Develop, refine and execute on the Target Product Profile (TPP) and ensure all development activities are designed to achieve a competitive and differentiated label that meets both regulatory requirements and payer/market needs.
Partner with Medical Affairs and Clinical to drive an integrated evidence generation strategy (including RWE and HEOR) to support global market access and reimbursement.
Lead the GPT as the central decision-maker, ensuring that Clinical, CMC, Regulatory, Medical Affairs, and Commercial are aligned on the asset’s primary objectives.
Serve as the primary liaison between technical R&D (CMC/Clinical) and downstream functions (Commercial/Market Access) to ensure the asset is "launch-ready" from a supply and value-proposition perspective.
Proactively manage cross-functional priorities, trade-offs, and resource constraints to ensure the program remains on track.
Act as the lead presenter for the asset at Senior Executive Governance (e.g., Investment Committees, Portfolio Boards). Secure funding and alignment for major milestones (Phase 2/3 transitions).
Establish clear "Go/No-Go" decision points and objectively present data to governance to drive portfolio-level prioritization.
Lead formal risk assessments and develop robust contingency/back-up scenarios for clinical failures, regulatory shifts, or competitive market entries.
Strategize and execute the expansion of the asset into new indications, earlier lines of therapy, and novel combination regimens.
Ensure the IDP includes global geographic considerations and mandatory pediatric investigation plans.
Lead collaborations with academic cooperative groups and manage Joint Steering Committees for co-development assets with industry partners.
Serve as the asset expert for due diligence on potential in-licensing opportunities that complement the asset’s core strategy.
Build and maintain high-level relationships with global Key Opinion Leaders and participate in strategic partnering/investor discussions.
Continuously monitor the oncology landscape to adjust asset strategy in response to emerging "Standard of Care" shifts or competitor data readouts.

Requirements

What you’ll need

Mandatory Advanced Degree: Ph.D. in Life Sciences, Pharm.D., or an equivalent doctoral-level degree (e.g., MD).
Minimum of 15 years in pharmaceutical or biotechnology R&D, with a minimum of 8 years specifically in Oncology Asset Leadership or a similar high-level matrix role.
Documented success in leading a program through a global regulatory submission (NDA/BLA/MAA) and subsequent commercial launch.
Proven ability to influence and lead large cross-functional teams without direct line-management authority in a Big Pharma environment.
Experience managing large-scale program budgets and a sophisticated understanding of NPV/Asset Valuation models.
The ability to pivot between high-level strategic "Boardroom" discussions and technical "Deep Dives" into clinical protocols or CMC validation data.
Exceptional executive presence; able to challenge senior leadership and functional heads to ensure the best outcome for the asset.
Unwavering commitment to clinical data integrity and the ultimate delivery of meaningful outcomes to cancer patients.

Benefits

Comp & perks

Our culture of friendliness, respect, mutual appreciation and diversity creates a safe working environment where you can strive for excellence.
A wealth of career paths and development opportunities that support the development of innovative solutions and improving the quality of life.

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

Integrated Development PlanTarget Product Profilereal-world evidencehealth economics and outcomes researchrisk assessmentclinical protocolsCMC validationNPV modelsasset valuationregulatory submission

Soft Skills

leadershipinfluencecross-functional collaborationexecutive presencestrategic thinkingcommunicationrelationship buildingproblem-solvingdecision-makingadaptability

Certifications

Ph.D. in Life SciencesPharm.D.MD