OneTrust

Executive Medical Director, Clinical Leader – Neuroscience, Early Development, Experimental Medicine

OneTrust

full-time

Posted on:

Location Type: Hybrid

Location: Raritan • Massachusetts • New Jersey • United States

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Salary

💰 $232,000 - $401,350 per year

Job Level

Senior

About the role

  • Develop and lead clinical development strategies from IND/CTA through Phase I and Phase IIa Proof‑of‑Concept/Proof-of-Mechanism.
  • Integrate translational hypotheses, biomarker strategies, precision measures (for patient selection, pharmacodynamic measures) and patient‑centric approaches into clinical plans.
  • Ensure scientific rigor, clinical feasibility, and regulatory alignment in all development strategies.
  • Lead the design of innovative and lean signal seeking early-phase clinical trials, including adaptive and biomarker‑enriched designs.
  • Provide clinical oversight for study execution, including safety monitoring, dose selection, protocol amendments, and data interpretation.
  • Leads cross-functional clinical study teams and work closely with biomarker, PK/PD, biostatistics, and operations teams to ensure high‑quality clinical execution.
  • Be a core member of the early development compound team for specific assets.
  • Guide decision‑making at project milestones and participate in governance reviews.
  • Engage with regulatory affairs to inform early interactions with FDA, EMA, and other agencies.
  • Establish and maintain relationships with global key opinion leaders, academic partners, and clinical investigators.
  • Represent the company at scientific meetings, advisory boards, and consortiums in neuroscience and neurodegeneration.
  • Contributes to in-licensing evaluations and due-diligence activities.
  • Provide scientific and strategic leadership to clinical scientists and clinical development team members.
  • Mentor or manage junior clinicians or scientists within Early Development and Experimental Medicine.
  • Promote a culture of scientific excellence, patient focus, and collaborative innovation.

Requirements

  • Minimum 5 years of clinical research experience in the biopharmaceutical industry, academia, or equivalent setting.
  • Demonstrated experience leading early‑phase clinical trials; experience in PD, AD is highly desirable.
  • Proven track record of advancing programs through early development milestones.
  • Deep understanding of neurodegenerative diseases, including Alzheimer’s and Parkinson’s biology, clinical endpoints, and emerging modalities.
  • Strong knowledge of translational neuroscience, biomarkers, and experimental medicine approaches.
  • Experience with innovative trial designs, digital health tools, or fluid/imaging biomarkers is a plus.
  • Strategic thinker with the ability to influence and drive cross‑functional teams.
  • Outstanding communication and presentation skills, with the ability to engage senior leadership, and ensures alignment between various teams and stakeholders.
  • Demonstrated ability to work in an agile, innovation‑driven environment.
Benefits
  • medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance
  • participation in Company’s consolidated retirement plan (pension) and savings plan (401(k))
  • participation in Company’s long-term incentive program
  • Vacation – up to 120 hours per calendar year
  • Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
  • Holiday pay, including Floating Holidays – up to 13 days per calendar year
  • Work, Personal and Family Time - up to 40 hours per calendar year
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
clinical development strategiesearly-phase clinical trialsbiomarker strategiesadaptive trial designssafety monitoringdose selectiondata interpretationtranslational neuroscienceclinical endpointsexperimental medicine
Soft Skills
strategic thinkinginfluencecross-functional collaborationcommunication skillspresentation skillsmentoringleadershipscientific excellencepatient focuscollaborative innovation