Manager, Clinical Operations

Nuvalent, Inc.

Manager, Clinical Operations at Nuvalent overseeing clinical trial planning, execution, and data collection according to regulatory guidelines. Responsible for various aspects of clinical study conduct and ensuring high-quality results.

Posted 4/14/2026full-timeCambridge • Massachusetts • 🇺🇸 United StatesMid-LevelSenior💰 $125,000 - $145,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Manage multiple aspects of clinical studies working under the guidance and direction of the Clinical Program Lead.
Accountable for the delivery of project(s) to achieve agreed timelines, scope, quality, and budget.
Perform oversight of CRO and auxiliary vendors; identify risks and broker solutions.
Provide support and oversight managing the creation, maintenance and close out of TMF activities.
Ensure appropriate escalation of enrollment, site activation and data collection milestones.
Support the clinical team to ensure the completeness of clinical protocol, investigator brochure, informed consent forms, clinical study reports and case report forms.
Ensure site monitoring reports are accurate and thorough, reviewed on a regular basis and that metrics are adhered to.
Support database lock by ensuring appropriate oversight of sites and by participating in data review/reconciliation efforts.
Coordinate with Clinical Supply Chain regarding drug forecasting and supply of drug product to sites.
Establish and maintain effective communication and collaboration with functional area peers to meet study/program objectives and support goals.
Lead or co-lead department initiatives to support an expanding organization.
Travel may be required (10% – 15%).

Requirements

What you’ll need

Bachelor’s degree or higher in a scientific or healthcare discipline preferred with 3+ years relevant experience in clinical operations within the biotech, pharmaceutical or CRO industry.
Extensive knowledge of ICH-GCP guidelines.
Relevant experience in early through late Phase clinical trials.
Knowledge of oncology clinical trials preferred.
Demonstrated cross-functional leadership fostering team spirit and team motivation.
Capability to challenge status-quo using risk management approach.

Benefits

Comp & perks

medical, dental, and vision insurance
401(k) retirement savings plan
generous paid time off (including a summer and winter company shutdown)
competitive total rewards package

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

clinical operationsproject managementTMF activitiesdata reviewrisk managementclinical trial oversightsite monitoringdrug forecastingclinical protocol developmentcase report forms

Soft Skills

cross-functional leadershipteam motivationeffective communicationcollaborationproblem-solvingrisk identificationsolution brokeringorganizational skillstime managementadaptability