Proposing and developing assays for hit identification strategies for new programs and to drive hit-to-lead and lead optimization projects
collaborating within a cross-functional project team to improve compound potency, properties, and understanding of compound mechanism of action (MoA)
work collaboratively through interactions across TAs within NN
managing a number of contract research organizations (CRO) across the globe
supporting the preparation of patents, reports, scientific publications, and serving as functional expert in supporting IND filings
Lead functional groups for the design, development, validation, and implementation of biochemical & biophysical assays for small molecule hit ID and MoA
Analyze, interpret, and communicate high-quality data to a multi-disciplinary project team
Manage global CROs and external partners on a day-to-day basis to achieve project goals
Develop and direct collaborations with external CROs performing assay development and transfer, library screening, and hit validation across projects
Has accountability for CROs timelines and data quality
Enhance operational efficiency and implementing best practices within Line of Business (LoB)
Critically evaluate project data while rigorously driving data-driven Go/No-go decisions, including the identification of resource constraints and bottlenecks
Communicate project plans/priorities to management
Effectively communicate and collaborate across global sites
Represent the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents
Contribute subject matter expertise to develop the research agenda with a clear understanding of the link between scientific project goals and overall long-term business needs
Propose new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas

Requirements

Master’s degree with 12+ years of relevant experience, or PhD with 8+ years of relevant experience required
8+ years of biochemistry and enzymology industry experience preferred
3+ years of previous experience managing CROs preferred
3+ years of biochemistry & biophysics work in a hybrid model preferred
In-depth knowledge in biochemical and biophysical assay development and validation
Expert in enzymology, enzyme kinetics, and current assay formats for multiple enzyme classes and protein-protein-interaction targets
Expert in steady-state and pre-steady state kinetics to determine enzyme and inhibitor mechanism of action
Broad experience in HTS assays
Expertise in utilizing a wide array of biochemical and biophysical technologies, including FI, FP, TR-FRET, AlphaScreen, radiometric methods, DSF, SPR, ITC, MST
Additional Hit finding knowledge: DEL, ASMS, and fragment-based screening beneficial
Experience developing and executing strategies to address key aspects of small molecule mechanism of action
Expert and hands-on experience with high throughput screening and hit validation techniques
Broad experience with automation beneficial
Demonstrated highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical and clinical development candidates
Impeccable attention to detail; Maintain detailed documentation
Experienced at writing IND reports and scientific papers
Broad experience with protein crystallography
Knowledge and experience using corporate database (e.g. CDD Vault/Abase, Dotmatics); Experience with data fitting software
Experience enhancing operational efficiency and implementing best practices within LoB
Track record of innovation and impact on programs documented with co-inventorship on issued patents and/or authorship of publications in peer-reviewed journals
Demonstrates excellent verbal and written communication skills, strong interpersonal skills with a demonstrated ability to work collaboratively on multidisciplinary teams
Proficient in Microsoft Office suite of products (Outlook, Excel, Word, PowerPoint)

Benefits

medical, dental and vision coverage
life insurance
disability insurance
401(k) savings plan
flexible spending accounts
employee assistance program
tuition reimbursement program
voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance
time off pursuant to its sick time policy
flexible vacation policy
parental leave policy

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

biochemical assay developmentbiophysical assay validationenzyme kineticshigh throughput screeninghit validation techniquesprotein-protein interactionsteady-state kineticspre-steady state kineticsdata analysisproject execution

Soft Skills

collaborationcommunicationattention to detailproject managementinterpersonal skillsinnovationproblem-solvingleadershipcritical evaluationstrategic thinking

Certifications

Master's degreePhD