Novo Nordisk

Principal Scientist – Medicinal Chemistry

Novo Nordisk

full-time

Posted on:

Location Type: Office

Location: Lexington • Massachusetts • United States

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Salary

💰 $152,700 - $267,300 per year

Job Level

Lead

About the role

  • Lead drug discovery projects from hit validation to development candidate selection using all modern medicinal chemistry techniques to deliver low dose and safe oral therapies.
  • Work collaboratively to strategize with corresponding functional area teams.
  • Set the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally.
  • Communicate project plans/priorities to management and governance.
  • Lead the preparation of patents, reports, and scientific publications.
  • Manage global CROs and external partners on a day-to-day basis to achieve project goals.
  • Has accountability for CROs timelines and data quality.
  • Has accountability and is a contributor to SM inventorship.
  • Serve as functional area expert in due diligence teams and early discovery partnerships & collaborations.
  • Effectively communicates and collaborates across global sites and sets project strategy by providing leadership of cross-functional project teams.
  • Represents the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents.
  • Proposes and oversees external collaborations.
  • Leader in the field of synthetic chemistry and small molecule drug design including but not limited to structure-based drug design (SBDD), phenotypic approaches, covalent modifiers, molecular glues, etc.
  • Leads global, cross-functional experimental teams to achieve project goals and compound target profiles (PTP).
  • Provides significant mentorship and training of senior colleagues.
  • Contributes subject matter expertise to develop the research agenda with a clear understanding of the link between scientific project goals and overall long-term business needs.
  • Proposes new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas.

Requirements

  • Master’s degree with 12+ years of relevant experience, or PhD with 8+ years of relevant experience required
  • Expert in all aspects of modern medicinal chemistry including, but not limited to SBDD, multi-parameter optimization (MPO) and phenotypic-based drug discovery
  • Strong working knowledge of biochemistry, biophysics, ADME, pharmacokinetics, biology, pharmacology, DMPK, and toxicology
  • Track record of advancing programs through the stages of drug development from HTS to Pre-clinical Candidate selection
  • Demonstrated ability to make strategic recommendations with timely go/no-go decisions at all stages of the drug discovery process
  • Proven cross-functional leadership experience as co-project team leader
  • Broad experience working with CRO partners
  • Track record of innovation and impact on programs documented with co-inventorship on issued patents and authorship of publications in peer-reviewed journals
  • Demonstrates excellent verbal and written communication skills
  • Proficient in Microsoft Office suite of products (Outlook, Excel, Word, PowerPoint)
Benefits
  • medical, dental and vision coverage
  • life insurance
  • disability insurance
  • 401(k) savings plan
  • flexible spending accounts
  • employee assistance program
  • tuition reimbursement program
  • group legal
  • critical illness
  • identity theft protection
  • pet insurance
  • auto/home insurance
  • time off pursuant to sick time policy
  • flexible vacation policy
  • parental leave policy
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
medicinal chemistrystructure-based drug designmulti-parameter optimizationphenotypic-based drug discoverybiochemistrybiophysicsADMEpharmacokineticsDMPKtoxicology
Soft Skills
leadershipcommunicationcollaborationmentorshipstrategic thinkingproject managementdecision makinginnovationcross-functional teamworkproblem solving
Certifications
Master’s degreePhD