Senior Bioinformatics Scientist

Natera

Senior Bioinformatics Scientist developing algorithms and pipelines for early cancer detection. Collaborating within teams to analyze complex genomic datasets and advance diagnostics.

Posted 7/31/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $118,800 - $148,500 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in developing advanced algorithms and statistical models for genomic data analysis, with a strong focus on high-throughput DNA sequencing and bioinformatics methodologies. Proficient in Python and cloud-based computing, with the ability to communicate complex findings effectively to cross-functional teams.

Highest-signal resume keywords

PhD In BioinformaticsHigh-Throughput DNA Sequencing AnalysisPython ProficiencyWorkflow Orchestration (WDL)Cloud Computing (AWS)

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Algorithm DesignStatistical ModelingVariant CallingData StructuresComputational Complexity AnalysisMulti-Omic Data AnalysisAutomated Quality ControlBioinformatics MethodologiesLinux ProficiencyShell Scripting

Soft Skills

Excellent Communication Skills

Tools & Technologies

NumPyPandasScikit-LearnAWSWDLTCGACOSMICOncoKB

Industry Keywords

BioinformaticsComputational BiologyCancer BiologyGenomic DatabasesClinical Diagnostics

Tech Stack

Tools & technologies

AWSCloudLinuxNumpyPandasPythonScikit-LearnShell Scripting

About the role

Key responsibilities & impact

Innovate, design, develop, and validate advanced algorithms and statistical models to extract actionable insights from large-scale genomic datasets for early cancer detection.
Co-architect, implement, and deploy automated analysis workflows for clinical diagnostics, ensuring robust performance for variant calling, fusion detection, and automated quality control.
Contribute to rigorous code reviews, maintain comprehensive technical documentation, and drive the continuous optimization of core computational infrastructure.
Analyze complex multi-omic data using high-performance internal pipelines, collaborating closely with wet-lab scientists and statisticians to meet critical research milestones.

Requirements

What you’ll need

PhD in Bioinformatics, Computer Science, Engineering, Statistics, Cancer Biology or similar field.
0–3 years of professional or postgraduate experience in bioinformatics or computational biology.
Excellent communication skills with a demonstrated ability to present complex computational findings to diverse cross-functional stakeholders.
Deep expertise in high-throughput DNA sequencing (NGS) analysis, including sequence alignment, mapping, and clinical-grade variant calling.
A proven track record of developing state-of-the-art, high-impact bioinformatics methodologies.
Advanced knowledge of data structures, algorithm design, and computational complexity analysis.
High proficiency in Python and its scientific ecosystem (NumPy, Pandas, Scikit-learn) for data manipulation and automation.
Experience with workflow orchestration languages (WDL preferred) for building and versioning scalable bioinformatics pipelines.
Experience with cloud-based distributed computing environments, specifically AWS.
Familiarity with contemporary analytical techniques and biomarkers in cancer biology.
Working knowledge of public genomic databases such as TCGA, COSMIC, or OncoKB.
Proficiency in Linux environments, including command-line tools and shell scripting.

Benefits

Comp & perks

Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
Free testing for Natera employees and their immediate families.
Fertility care benefits.
Pregnancy and baby bonding leave.
401k benefits.
Commuter benefits.
Generous employee referral program!