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Natera

Senior AI/ML Engineer

Natera

Senior AI/ML Engineer designing and building Generative AI systems for Natera, impacting patient outcomes and clinical innovation with robust AI platforms.

Posted 6/3/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $125,000 - $156,300 per yearWebsite

Tech Stack

Tools & technologies
AWSCloudDistributed SystemsKubernetesPythonPyTorchSparkTensorflowTerraform

About the role

Key responsibilities & impact
  • Design and implement foundational GenAI services: vector search, prompt tuning, agent orchestration, document extraction, context/memory services, model/endpoint registry, feature/embedding stores, guardrails, and evaluation pipelines
  • Build the underlying infrastructure for autonomous and semi-autonomous AI agents including support for agent collaboration, reasoning, and memory persistence, enabling continuous context-aware execution
  • Build standardized APIs/SDKs that make it easy for product teams to compose, deploy, and monitor Generative AI workloads.
  • Ensure platform components meet enterprise-grade requirements for scalability, latency, multi-region resilience, and cost efficiency
  • Stand up LLM runtimes with token/rate governance, caching, and safe tool-use
  • Implement RAG at scale: ingestion pipelines, chunking/embedding policies, hybrid search, relevance/risk scoring, and feedback loops
  • Build agent orchestration (single & multi-agent) with planning, tool routing, shared/persistent memory, and inter-agent communication
  • Integrate tooling and APIs that allow agents to interact with internal systems, retrieve data securely, and take action under strict controls
  • Collaborate with research teams to prototype and productionize multi-agent architectures for workflow automation, report generation, and data synthesis.
  • Implement cloud-native infrastructure for large-scale model training and serving using Kubernetes, MLflow, Terraform, and AWS-native services
  • Automate data and model pipelines for RAG, LLM fine-tuning, and agent orchestration
  • Integrate observability tools (Datadog or equivalent) for real-time performance, drift detection and safety monitoring of AI outputs
  • Optimize compute and storage architecture to ensure cost-effective scaling of large models and multi-agent workloads
  • Partner with security, data governance, SRE, and application teams to productize platform capabilities
  • Embed compliance-by-design (HIPAA/CLIA/CAP/FDA/GDPR): PHI/PII handling, encryption, access controls, audit trails
  • Implement guardrails: input/output filters, prompt hardening, allow/deny policies for tool execution, policy-as-code in CI/CD
  • Bias/explainability hooks and automated evaluations for RAG/LLM/agents; drift and regression detection
  • Establish golden paths (templates, examples, docs) and lead platform architecture reviews, code reviews, and design discussions
  • Partner with data scientists, AI researchers, and product engineers to deliver reliable and maintainable AI services
  • Mentor junior engineers in platform development, distributed systems, and agentic AI infrastructure concepts
  • Influence cross-functional roadmaps by partnering with Product and Engineering leadership to align delivery with business needs

Requirements

What you’ll need
  • 8+ years in software/ML engineering, with 5+ years in ML engineering at scale
  • Expertise in building production-grade ML/LLM systems on AWS tech stack (Python, TensorFlow/PyTorch, Spark, MLflow/Kubeflow, vector DBs)
  • Proven track record with GenAI/LLMs: fine-tuning, RAG, prompt orchestration, agentic systems, safety guardrails, monitoring, and cost optimization
  • Hands-on with RAG systems (embeddings, vector DBs, retrieval policies) and LLM runtime operations (caching, quotas, multi-model routing)
  • Experience building agentic AI platforms (LangChain, LlamaIndex, CrewAI, Semantic Kernel, or custom)
  • Deep knowledge of data-intensive systems, distributed architectures, and cloud-native development
  • Strong grounding in compliance-first engineering in healthcare, biotech, or diagnostics preferred
  • Track record building secure, compliant data/AI systems and automating policy checks.
  • Excellent ability to influence across teams, mentor engineers, and set technical standards.

Benefits

Comp & perks
  • Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
  • Free testing for employees and their immediate families in addition to fertility care benefits.
  • Pregnancy and baby bonding leave
  • 401k benefits
  • Commuter benefits
  • Generous employee referral program

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools
GenAI servicesvector searchprompt tuningagent orchestrationdocument extractionRAG systemsLLM systemscloud-native developmentdata pipelinesdistributed systems
Soft Skills
mentoringinfluencingcollaborationcommunicationleadershiptechnical standards settingcross-functional partnershipproblem-solvingdesign discussionscode reviews