Director of Statistical Programming

Natera

Director of Statistical Programming leading statistical programming for oncology clinical trials at Natera. Providing strategic oversight for regulatory submissions and analysis datasets.

Posted 4/29/2026full-timeRemote • 🇺🇸 United StatesLead💰 $186,400 - $233,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Build, mentor, and direct a high-performing statistical programming team, fostering technical excellence and overseeing their professional development.
Provide strategic direction and standards for the programming function, securing alignment with oncology clinical development goals and department infrastructure needs.
Act as the primary programming lead for regulatory submissions (e.g., 510(k), CTA/CDx, and PMA), ensuring all deliverables meet rigorous global standards.
Direct the generation and validation of analysis datasets and TLFs, ensuring data integrity and regulatory compliance with ICH, GCP, and FDA 21 CFR Part 11.
Lead the development, validation, and review of efficient R code to support statistical analyses and deliverables. Enforce departmental standards for programming maintenance and code integrity.
Lead the development and maintenance of scalable programming infrastructure for the larger Biostatistics department.
Partner with Biostatistics, Clinical Operations, Data Management, and Regulatory to integrate programming expertise into clinical study execution.

Requirements

What you’ll need

Minimum 10 years of relevant industry experience supporting clinical trials in diagnostics, biotechnology, pharmaceuticals, or related industries.
At least 5 years leading a team.
Advanced degree in Biostatistics, Statistics, Computer Science, or a related field.
Expert working knowledge of R for clinical trial reporting; experience maintaining statistical packages and computing environments under version control.
In-depth knowledge of CDISC standards including SDTM and ADaM.
Proven track record of producing high-quality analysis output for regulatory audiences (FDA) and internal stakeholders.
Proven record of hiring, mentoring, and developing a successful, productive team.
Demonstrated ability and enthusiasm for working on cross-functional teams with members of diverse technical backgrounds.
Exceptional problem-solving skills and attention to detail.
Prior experience with NGS, genetics, and/or oncology molecular diagnostic testing a plus.

Benefits

Comp & perks

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
Free testing for Natera employees and their immediate families in addition to fertility care benefits.
Pregnancy and baby bonding leave.
401k benefits.
Commuter benefits.
Generous employee referral program.

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

Rstatistical programmingdata integrityregulatory complianceCDISC standardsSDTMADaMstatistical analysesprogramming maintenanceversion control

Soft Skills

mentoringteam leadershipproblem-solvingattention to detailcross-functional collaborationstrategic directionprofessional developmentcommunicationtechnical excellencefostering teamwork

Certifications

advanced degree in Biostatisticsadvanced degree in Statisticsadvanced degree in Computer Science