Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology, Immuno-Oncology

MSD

Senior Director leading advanced pharmacometrics and quantitative pharmacology for oncology. Overseeing modeling strategy decision-making in a global clinical development organization.

Posted 7/18/2026full-timeRahway • New Jersey, Pennsylvania • 🇺🇸 United StatesSenior💰 $210,400 - $331,100 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in quantitative pharmacology and advanced pharmacometrics, with a strong focus on oncology drug development and regulatory compliance. Proven ability to lead teams, develop innovative modeling strategies, and collaborate effectively across multidisciplinary functions.

Highest-signal resume keywords

Ph.D. In Pharmacokinetics/PharmacodynamicsAdvanced Pharmacometrics MethodsBayesian Hierarchical ModelsNONMEM SoftwareMIDD Application In Oncology

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Applicant Tracking System Keywords

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Hard Skills

PharmacokineticsPharmacodynamicsPharmacometricsMathematicsStatisticsBayesian ModelingPopulation PK/PD ModelingClinical Trial SimulationData ScienceOncology Drug Development

Soft Skills

LeadershipCollaborationMentoringScientific RigorInnovation

Tools & Technologies

NONMEMPumasStanRBayesian Platforms

Industry Keywords

Pharmaceutical Drug DevelopmentRegulatory ComplianceModel-Informed Drug DevelopmentClinical DesignBenefit-Risk Assessments

About the role

Key responsibilities & impact

Lead quantitative pharmacology strategy across the oncology portfolio, ensuring alignment with program goals and organizational priorities.
Develop and implement long-range plans for integrating MIDD, pharmacometrics, data science, and Bayesian modeling approaches to accelerate and de-risk oncology drug development.
Partner with senior leaders in Clinical Development, Translational Medicine, Biostatistics, Regulatory, and Data Science to define modeling strategies that influence program design and key decisions.
Oversee development of advanced pharmacometrics modeling including but not limited to population PK/PD, tumor dynamics and survival modeling, advanced models to inform dose selection, clinical design, and benefit–risk assessments.
Champion the use of Bayesian methods including hierarchical and joint modeling, and prior-data integration to strengthen oncology decision-making.
Ensure high-quality, regulatory grade pharmacometric deliverables for submissions, label negotiations, and scientific advice meetings.
Stay at the forefront of emerging methodologies including AI/ML and promote innovation in modeling tools, computational frameworks, and analytics platforms.
Lead, mentor, and develop a team of quantitative scientists in a matrixed role.
Foster a culture of scientific rigor, excellence, collaboration, and innovation.
Collaborate with QP2 leads to design efficient, model-informed clinical trials
Contribute to regulatory strategy through preparation of pharmacometric reports, briefing documents, and presentations.

Requirements

What you’ll need

Ph.D. in pharmacokinetics/pharmacodynamics, pharmacometrics, mathematics, statistics/biostatistics, chemical/biomedical engineering, or a related discipline with at least 10 years of pharmaceutical drug development experience, including substantial experience in pharmacometrics roles
OR Master’s, PharmD, or equivalent degree with at least 15 years of pharmaceutical drug development experience, with a demonstrated record of increasing responsibility, independence, and leadership in similar roles
Extensive and in-depth experience in application of MIDD in oncology drug development to drive impactful development decisions
Deep proficiency in advanced pharmacometrics methods such as: Bayesian hierarchical models, joint models of tumor and survival, drop-out models, MBMA, advanced clinical trial simulation methods, integrating PROs and RWD into traditional NLME approaches
Hands-on experience with software such as NONMEM, Pumas, Stan, R, and/or other Bayesian platforms

Benefits

Comp & perks

medical, dental, vision healthcare and other insurance benefits (for employee and family)
retirement benefits, including 401(k)
paid holidays
vacation
compassionate and sick days