Senior Director, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology

MSD

Senior Director leading quantitative pharmacology and pharmacometrics strategies in oncology. Collaborating across teams to inform drug development decisions and regulatory strategies.

Posted 6/15/2026full-timeRahway • New Jersey, Pennsylvania • 🇺🇸 United StatesSenior💰 $210,400 - $331,100 per yearWebsite

About the role

Key responsibilities & impact

Lead and shape quantitative pharmacology strategy across oncology programs to inform key development decisions (e.g., dose selection, trial design, go/no-go decisions)
Develop and implement integrated MIDD strategies to support decision-making across development stages
Ensure alignment of modeling strategies with regulatory expectations and business priorities
Maintain a comprehensive understanding of global regulatory expectations for small molecules, biologics including new modalities such as ADCs and TCEs
Lead, mentor, and develop a team of QP2 scientists, including performance management, hiring, retention, and talent development
Provide scientific and operational oversight to team members, ensuring high-quality and timely deliverables
Contribute to broader QP2 and Oncology leadership initiatives, including talent strategies and organizational priorities
Identify and support resource planning and allocation in partnership with senior leadership
Serve as QP2 lead on assigned programs and represent QP2 in cross-functional teams and governance forums
Collaborate with Translational, Clinical, and Biostatistics teams to integrate quantitative insights into development strategies
Partner with preclinical teams to ensure appropriate translation of nonclinical findings into clinical development plans
Contribute to due diligence for business development and licensing opportunities
Develop and contribute to regulatory strategies, including authoring and reviewing key documents (e.g., INDs, CSRs, CTD modules, NDA/BLA submissions)
Ensure delivery of high-quality clinical pharmacology and pharmacometric analyses and reports
Represent the company in interactions with regulatory agencies, scientific conferences, and external collaborations

Requirements

What you’ll need

Ph.D. in pharmacokinetics/pharmacodynamics, pharmacometrics, mathematics, statistics/biostatistics, chemical/biomedical engineering, or related discipline with ≥10 years of relevant pharmaceutical industry experience OR Master’s, PharmD, or equivalent degree with ≥15 years of relevant pharmaceutical industry experience
Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, mathematics, computational biology, or a related field
Oncology therapeutic area or disease knowledge
Demonstrated ability to lead an interdisciplinary team or taskforce, and/or to oversee the work of others
Extensive experience in developing quantitative strategies for impacting pipeline decisions, and drug development expertise
Ability to influence regulatory strategies including prior experience independently authoring and defending regulatory filings for marketing authorization (NDA/MAA)
Record of ability to operate in an inclusive and high-performance work environment applying enterprise ways of working principles including fostering collaboration and driving results, while managing ambiguity
Relevant regulatory and quantitative pharmacology experience
Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning

Benefits

Comp & perks

medical, dental, vision healthcare and other insurance benefits (for employee and family)
retirement benefits, including 401(k)
paid holidays
vacation
compassionate and sick days

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

pharmacokineticspharmacodynamicspharmacometricsmathematicsstatisticsbiostatisticsdrug developmentquantitative strategiesregulatory filingsclinical pharmacology

Soft Skills

leadershipmentoringcollaborationcommunicationproblem solvingteam managementinfluenceorganizational skillsperformance managementresource planning